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Article: Identification of a single genotype of hepatitis G virus by comparison of one complete genome from a healthy carrier with eight from patients with hepatitis

TitleIdentification of a single genotype of hepatitis G virus by comparison of one complete genome from a healthy carrier with eight from patients with hepatitis
Authors
Issue Date1997
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 1997, v. 78 n. 12, p. 3247-3253 How to Cite?
AbstractDifferent isolates of a putative hepatitis virus called hepatitis GB virus C or hepatitis G virus (HGV) have been cloned recently from patients with hepatitis. This virus has also been found commonly in healthy carriers. We have cloned and sequenced a complete HGV genome, designated HGVCN, from a healthy Chinese blood donor. HGVCN shares 85.8-90.0% nucleotide sequence identity and 95.4-97.5% amino acid identity with the eight available full-length HGV genomes. Furthermore, the majority (82.8%) of the nucleotide substitutions found in HGVCN were synonymous and a fairly uniform distribution of changes was found across the entire genome without identification of any hypervariable region. When compared with the African isolates GBVC and GBVC-EA, the HGVCN-encoded polyprotein contained a 31 amino acid N-terminal extension which was predicted to be a defective core-like sequence. The sequences of the HGV E1 and E2 proteins displayed unique motifs and were highly conserved. Phylogenetic analysis revealed that all nine complete HGV isolates were closely related and that HGVCN grouped with the other Chinese HGV isolate (HGVC964). Taken together, our findings suggest that there is one single genotype of HGV and that the HGV genome cloned from the healthy carrier is not significantly different from those derived from patient sera.
Persistent Identifierhttp://hdl.handle.net/10722/147413
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, HLen_US
dc.contributor.authorHou, YDen_US
dc.contributor.authorJin, DYen_US
dc.date.accessioned2012-05-29T06:03:33Z-
dc.date.available2012-05-29T06:03:33Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of General Virology, 1997, v. 78 n. 12, p. 3247-3253en_US
dc.identifier.issn0022-1317en_US
dc.identifier.urihttp://hdl.handle.net/10722/147413-
dc.description.abstractDifferent isolates of a putative hepatitis virus called hepatitis GB virus C or hepatitis G virus (HGV) have been cloned recently from patients with hepatitis. This virus has also been found commonly in healthy carriers. We have cloned and sequenced a complete HGV genome, designated HGVCN, from a healthy Chinese blood donor. HGVCN shares 85.8-90.0% nucleotide sequence identity and 95.4-97.5% amino acid identity with the eight available full-length HGV genomes. Furthermore, the majority (82.8%) of the nucleotide substitutions found in HGVCN were synonymous and a fairly uniform distribution of changes was found across the entire genome without identification of any hypervariable region. When compared with the African isolates GBVC and GBVC-EA, the HGVCN-encoded polyprotein contained a 31 amino acid N-terminal extension which was predicted to be a defective core-like sequence. The sequences of the HGV E1 and E2 proteins displayed unique motifs and were highly conserved. Phylogenetic analysis revealed that all nine complete HGV isolates were closely related and that HGVCN grouped with the other Chinese HGV isolate (HGVC964). Taken together, our findings suggest that there is one single genotype of HGV and that the HGV genome cloned from the healthy carrier is not significantly different from those derived from patient sera.en_US
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_US
dc.relation.ispartofJournal of General Virologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshFlaviviridae - Geneticsen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHepatitis, Viral, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshSequence Analysisen_US
dc.subject.meshViral Structural Proteins - Geneticsen_US
dc.titleIdentification of a single genotype of hepatitis G virus by comparison of one complete genome from a healthy carrier with eight from patients with hepatitisen_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9400975-
dc.identifier.scopuseid_2-s2.0-0030829922en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030829922&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue12en_US
dc.identifier.spage3247en_US
dc.identifier.epage3253en_US
dc.identifier.isiWOS:A1997YJ43200021-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, HL=8081373900en_US
dc.identifier.scopusauthoridHou, YD=7402198565en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US

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