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Article: The vaccinia virus HindIII K fragment encodes a novel protein belonging to the serpin superfamily.

TitleThe vaccinia virus HindIII K fragment encodes a novel protein belonging to the serpin superfamily.
Authors
Issue Date1990
PublisherScience in China Press. The Journal's website is located at http://chem.scichina.com:8081/sciBe/EN/volumn/current.shtml
Citation
Science In China. Series B, Chemistry, Life Sciences & Earth Sciences, 1990, v. 33 n. 4, p. 453-459 How to Cite?
AbstractThe 1983-base pair nucleotide sequence of the EcoRI-HindIII fragment of vaccinia virus Tiantan strain HindIII K clone is determined by the dideoxy chain termination method. A search in the NBRF protein sequence database using FASTA and other microcomputer programs reveals that several proteins belonging to the serpin (serine protease inhibitor) superfamily have striking similarities to the protein encoded by the HindIII K1 ORF. On the basis of the dot-matrix analysis and sequence alignment, the K1-encoded protein is shown as a novel member of the serpin superfamily. The putative reactive site and switch sequence of this novel serpin are then compared with those of other serpins. The probable evolutionary and possible functional relationships are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/147354
ISSN
1998 Impact Factor: 0.479
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJin, Qen_US
dc.contributor.authorJin, DYen_US
dc.contributor.authorHou, YDen_US
dc.date.accessioned2012-05-29T06:03:08Z-
dc.date.available2012-05-29T06:03:08Z-
dc.date.issued1990en_US
dc.identifier.citationScience In China. Series B, Chemistry, Life Sciences & Earth Sciences, 1990, v. 33 n. 4, p. 453-459en_US
dc.identifier.issn1001-652Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147354-
dc.description.abstractThe 1983-base pair nucleotide sequence of the EcoRI-HindIII fragment of vaccinia virus Tiantan strain HindIII K clone is determined by the dideoxy chain termination method. A search in the NBRF protein sequence database using FASTA and other microcomputer programs reveals that several proteins belonging to the serpin (serine protease inhibitor) superfamily have striking similarities to the protein encoded by the HindIII K1 ORF. On the basis of the dot-matrix analysis and sequence alignment, the K1-encoded protein is shown as a novel member of the serpin superfamily. The putative reactive site and switch sequence of this novel serpin are then compared with those of other serpins. The probable evolutionary and possible functional relationships are discussed.en_US
dc.languageengen_US
dc.publisherScience in China Press. The Journal's website is located at http://chem.scichina.com:8081/sciBe/EN/volumn/current.shtml-
dc.relation.ispartofScience in China. Series B, Chemistry, life sciences & earth sciencesen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshGenes, Viralen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPeptide Fragments - Geneticsen_US
dc.subject.meshPlasmidsen_US
dc.subject.meshSerine Proteinase Inhibitorsen_US
dc.subject.meshVaccinia Virus - Enzymology - Geneticsen_US
dc.subject.meshAlpha 1-Antitrypsin - Geneticsen_US
dc.titleThe vaccinia virus HindIII K fragment encodes a novel protein belonging to the serpin superfamily.en_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2372373en_US
dc.identifier.scopuseid_2-s2.0-0025411799en_US
dc.identifier.scopuseid_2-s2.0-45149139433-
dc.identifier.volume33en_US
dc.identifier.issue4en_US
dc.identifier.spage453en_US
dc.identifier.epage459en_US
dc.identifier.isiWOS:A1990DB56600009-
dc.publisher.placeChina-
dc.identifier.scopusauthoridJin, Q=35210232500en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridHou, YD=7402198565en_US

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