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Article: Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis

TitleSequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis
Authors
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2012, v. 55 n. 5, p. 1453-1461 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs. In this study, we analyzed the microRNA (miRNA) expression profiles of nontumorous livers, primary HCCs, and venous metastases in the same livers from 20 HCC patients by way of TaqMan low-density array (TLDA) and identified the precise alterations of miRNA expression from nontumorous livers to primary HCCs and venous metastases globally. By unsupervised clustering analysis, nontumorous livers were distinctly segregated from primary HCCs and venous metastases, whereas no discernible difference in the expression pattern could be found between primary HCCs and venous metastases. However, a marked global reduction of miRNA expression levels was detected in venous metastases, as compared with primary HCCs. These data suggest that miRNA deregulation is an early event in liver carcinogenesis and the later global miRNA down-regulation aggravates the preexisting miRNA deregulation to further promote HCC metastasis. CONCLUSION: Our study has enriched the current understanding of the deregulation of miRNAs in HCC progression and highlighted the sequential and distinctive alterations of miRNA expression in primary HCC and venous metastasis formation.
Persistent Identifierhttp://hdl.handle.net/10722/146927
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 1/06C
HKU 7/CRG/09
Funding Information:

Supported by the Hong Kong Research Grants Council Collaborative Research Fund (HKU 1/06C and HKU 7/CRG/09).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorWong, CMen_HK
dc.contributor.authorWong, CCLen_HK
dc.contributor.authorLee, CMFen_HK
dc.contributor.authorFan, DNYen_HK
dc.contributor.authorAu, SLKen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2012-05-23T05:50:24Z-
dc.date.available2012-05-23T05:50:24Z-
dc.date.issued2012en_HK
dc.identifier.citationHepatology, 2012, v. 55 n. 5, p. 1453-1461en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146927-
dc.description.abstractHepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs. In this study, we analyzed the microRNA (miRNA) expression profiles of nontumorous livers, primary HCCs, and venous metastases in the same livers from 20 HCC patients by way of TaqMan low-density array (TLDA) and identified the precise alterations of miRNA expression from nontumorous livers to primary HCCs and venous metastases globally. By unsupervised clustering analysis, nontumorous livers were distinctly segregated from primary HCCs and venous metastases, whereas no discernible difference in the expression pattern could be found between primary HCCs and venous metastases. However, a marked global reduction of miRNA expression levels was detected in venous metastases, as compared with primary HCCs. These data suggest that miRNA deregulation is an early event in liver carcinogenesis and the later global miRNA down-regulation aggravates the preexisting miRNA deregulation to further promote HCC metastasis. CONCLUSION: Our study has enriched the current understanding of the deregulation of miRNAs in HCC progression and highlighted the sequential and distinctive alterations of miRNA expression in primary HCC and venous metastasis formation.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_US
dc.subject.meshCarcinoma, Hepatocellular - genetics - mortality - pathology - secondary-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshLiver Neoplasms - genetics - mortality - pathology-
dc.subject.meshMicroRNAs - genetics - metabolism-
dc.subject.meshVascular Neoplasms - genetics - mortality - secondary-
dc.titleSequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasisen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_HK
dc.identifier.emailWong, CCL: carmencl@pathology.hku.hken_HK
dc.identifier.emailLee, CMF: joyce@pathology.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityWong, CCL=rp01602en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.25512en_HK
dc.identifier.pmid22135159-
dc.identifier.scopuseid_2-s2.0-84859986442en_HK
dc.identifier.hkuros199501en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859986442&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1453en_HK
dc.identifier.epage1461en_HK
dc.identifier.eissn1527-3350-
dc.identifier.isiWOS:000303049400016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f100013410969-
dc.relation.projectMolecular pathology of liver cancer - a multidisciplinary study-
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridAu, SLK=36460622800en_HK
dc.identifier.scopusauthoridFan, DNY=37025892500en_HK
dc.identifier.scopusauthoridLee, JMF=39561284400en_HK
dc.identifier.scopusauthoridWong, CCL=24823630000en_HK
dc.identifier.scopusauthoridWong, CM=16314668400en_HK

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