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Article: Executive function in first-episode schizophrenia: A three-year prospective study of the Hayling Sentence Completion Test

TitleExecutive function in first-episode schizophrenia: A three-year prospective study of the Hayling Sentence Completion Test
Authors
KeywordsCognitive function
Executive function
First-episode schizophrenia
Hayling
Longitudinal
Medication-naïve
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2012, v. 135 n. 1-3, p. 62-67 How to Cite?
AbstractIn recent decade, deficits in the mechanism of Supervisory Attentional System (SAS) have become increasingly influential in explaining the nature of dysexecutive syndrome experienced by schizophrenic patients. The SAS model is characterized by having a detailed sub-classification of specific executive function components, among which semantic inhibition has been investigated using the Hayling Sentence Completion Test (HSCT). Several studies thus far have indicated that schizophrenic patients show impairment in HSCT performance. However, HSCT data concerning first-episode patients is still scarce. Besides, as previous HSCT studies were all cross-sectional in nature, they were not able to assess changes in HSCT performance over time. In order to address the paucity of knowledge about the longitudinal trajectories and correlates of semantic inhibition deficits in early schizophrenia, this paper reports a three-year prospective study of HSCT performance in medication-naïve, first-episode patients with schizophrenia-spectrum disorders. HSCT performance was assessed in 34 patients at four times over a period of three years, while the 34 healthy controls were assessed once. We found that medication-naïve patients demonstrated impairment in the inhibition condition in HSCT as compared to controls, but not in the initiation condition. Such HSCT impairment gradually improved in the three years following the first psychotic episode; however, HSCT performance did not predict improvement in negative or positive symptoms over the three-year period. The present findings suggest that semantic inhibition impairment is a specific deficit in schizophrenia that may require early intervention efforts, with the goal of facilitating more successful verbal communication and thereby better interpersonal functioning. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/146912
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorXu, JQen_HK
dc.contributor.authorLiu, KCMen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-05-23T05:49:18Z-
dc.date.available2012-05-23T05:49:18Z-
dc.date.issued2012en_HK
dc.identifier.citationSchizophrenia Research, 2012, v. 135 n. 1-3, p. 62-67en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146912-
dc.description.abstractIn recent decade, deficits in the mechanism of Supervisory Attentional System (SAS) have become increasingly influential in explaining the nature of dysexecutive syndrome experienced by schizophrenic patients. The SAS model is characterized by having a detailed sub-classification of specific executive function components, among which semantic inhibition has been investigated using the Hayling Sentence Completion Test (HSCT). Several studies thus far have indicated that schizophrenic patients show impairment in HSCT performance. However, HSCT data concerning first-episode patients is still scarce. Besides, as previous HSCT studies were all cross-sectional in nature, they were not able to assess changes in HSCT performance over time. In order to address the paucity of knowledge about the longitudinal trajectories and correlates of semantic inhibition deficits in early schizophrenia, this paper reports a three-year prospective study of HSCT performance in medication-naïve, first-episode patients with schizophrenia-spectrum disorders. HSCT performance was assessed in 34 patients at four times over a period of three years, while the 34 healthy controls were assessed once. We found that medication-naïve patients demonstrated impairment in the inhibition condition in HSCT as compared to controls, but not in the initiation condition. Such HSCT impairment gradually improved in the three years following the first psychotic episode; however, HSCT performance did not predict improvement in negative or positive symptoms over the three-year period. The present findings suggest that semantic inhibition impairment is a specific deficit in schizophrenia that may require early intervention efforts, with the goal of facilitating more successful verbal communication and thereby better interpersonal functioning. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCognitive functionen_HK
dc.subjectExecutive functionen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectHaylingen_HK
dc.subjectLongitudinalen_HK
dc.subjectMedication-naïveen_HK
dc.titleExecutive function in first-episode schizophrenia: A three-year prospective study of the Hayling Sentence Completion Testen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2011.12.022en_HK
dc.identifier.pmid22260962-
dc.identifier.scopuseid_2-s2.0-84862806406en_HK
dc.identifier.hkuros199759en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862806406&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage62en_HK
dc.identifier.epage67en_HK
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000300940000011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, KKS=36882457400en_HK
dc.identifier.scopusauthoridXu, JQ=55261426000en_HK
dc.identifier.scopusauthoridLiu, KCM=42461807300en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike10280331-

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