File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Three-year outcome of phase-specific early intervention for first-episode psychosis: A cohort study in Hong Kong

TitleThree-year outcome of phase-specific early intervention for first-episode psychosis: A cohort study in Hong Kong
Authors
KeywordsCommunity mental health service
Early diagnosis
Follow-up study
Programme evaluation
Psychotic disorder
Issue Date2011
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1
Citation
Early Intervention In Psychiatry, 2011, v. 5 n. 4, p. 315-323 How to Cite?
AbstractAim: Although phase-specific early intervention for first-episode psychosis has been implemented in many different parts of the world, limited medium-term outcome data are available in non-Western populations with relatively low mental health resources. The study aimed to determine the effectiveness of phase-specific early intervention in first-episode psychosis. Method: In this cohort study, we compared the 3-year outcome of 700 first-episode psychosis patients who received phase-specific early intervention with that of 700 patients matched for age, sex and diagnosis who received standard psychiatric care prior to early intervention. Using a structured data acquisition procedure, we determined functional outcome, symptom levels, relapse, recovery, suicidal behaviour and service utilization from clinical records. Results: Patients in the early intervention group had longer full-time employment or study (P<0.001), fewer days of hospitalization (P<0.001), less severe positive symptoms (P=0.006), less severe negative symptoms (P=0.001), fewer suicides (P=0.009) and fewer disengagements (P=0.002) than the historical control group. Additionally, more patients in the early intervention group experienced a period of recovery (P=0.001), but the two groups had similar rates of relapse (P=0.08) and durations of untreated psychosis (P=0.72). Conclusions: The 3-year outcome in phase-specific early intervention compared favourably with that of standard psychiatric care, particularly with respect to functional outcome and reduction in hospitalizations, suicides and disengagements. However, intervention did not appear to reduce the rate of relapse. © 2011 Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/146906
ISSN
2015 Impact Factor: 2.889
2015 SCImago Journal Rankings: 1.071
ISI Accession Number ID
Funding AgencyGrant Number
Food and Health Bureau, the Government of Hong Kong Special Administrative Region03040141
Janssen-Cilag
AstraZeneca
Pfizer
Eli Lilly
Sanofi-Aventis
Otsuka
Funding Information:

The study was supported by Health and Health Service Research Fund by the Food and Health Bureau, the Government of Hong Kong Special Administrative Region. The grant number was 03040141.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTang, YMJen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorChiu, CPen_HK
dc.contributor.authorLam, MMen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorYew, CWen_HK
dc.contributor.authorWong, GHen_HK
dc.contributor.authorChung, DWen_HK
dc.contributor.authorTso, Sen_HK
dc.contributor.authorChan, KPen_HK
dc.contributor.authorYip, KCen_HK
dc.contributor.authorHung, SFen_HK
dc.contributor.authorHoner, WGen_HK
dc.date.accessioned2012-05-23T05:49:16Z-
dc.date.available2012-05-23T05:49:16Z-
dc.date.issued2011en_HK
dc.identifier.citationEarly Intervention In Psychiatry, 2011, v. 5 n. 4, p. 315-323en_HK
dc.identifier.issn1751-7885en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146906-
dc.description.abstractAim: Although phase-specific early intervention for first-episode psychosis has been implemented in many different parts of the world, limited medium-term outcome data are available in non-Western populations with relatively low mental health resources. The study aimed to determine the effectiveness of phase-specific early intervention in first-episode psychosis. Method: In this cohort study, we compared the 3-year outcome of 700 first-episode psychosis patients who received phase-specific early intervention with that of 700 patients matched for age, sex and diagnosis who received standard psychiatric care prior to early intervention. Using a structured data acquisition procedure, we determined functional outcome, symptom levels, relapse, recovery, suicidal behaviour and service utilization from clinical records. Results: Patients in the early intervention group had longer full-time employment or study (P<0.001), fewer days of hospitalization (P<0.001), less severe positive symptoms (P=0.006), less severe negative symptoms (P=0.001), fewer suicides (P=0.009) and fewer disengagements (P=0.002) than the historical control group. Additionally, more patients in the early intervention group experienced a period of recovery (P=0.001), but the two groups had similar rates of relapse (P=0.08) and durations of untreated psychosis (P=0.72). Conclusions: The 3-year outcome in phase-specific early intervention compared favourably with that of standard psychiatric care, particularly with respect to functional outcome and reduction in hospitalizations, suicides and disengagements. However, intervention did not appear to reduce the rate of relapse. © 2011 Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1en_HK
dc.relation.ispartofEarly Intervention in Psychiatryen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectCommunity mental health serviceen_HK
dc.subjectEarly diagnosisen_HK
dc.subjectFollow-up studyen_HK
dc.subjectProgramme evaluationen_HK
dc.subjectPsychotic disorderen_HK
dc.subject.meshAntipsychotic Agents - therapeutic use-
dc.subject.meshCommunity Mental Health Services - organization and administration - utilization-
dc.subject.meshEarly Diagnosis-
dc.subject.meshEarly Medical Intervention-
dc.subject.meshPsychotic Disorders - diagnosis - drug therapy - psychology-
dc.titleThree-year outcome of phase-specific early intervention for first-episode psychosis: A cohort study in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChiu, CP: chiupyc@hku.hken_HK
dc.identifier.emailLam, MM: maylam11@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityChiu, CP=rp00291en_HK
dc.identifier.authorityLam, MM=rp00296en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1751-7893.2011.00279.xen_HK
dc.identifier.pmid21726421-
dc.identifier.scopuseid_2-s2.0-80055056453en_HK
dc.identifier.hkuros199752en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055056453&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue4en_HK
dc.identifier.spage315en_HK
dc.identifier.epage323en_HK
dc.identifier.isiWOS:000297018400006-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectOutcome of an early intervention programme for psychosis (EASY): a case controlled study-
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridTang, JY=35086815700en_HK
dc.identifier.scopusauthoridHui, CL=35734149500en_HK
dc.identifier.scopusauthoridChiu, CP=8627115700en_HK
dc.identifier.scopusauthoridLam, MM=13106178700en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridYew, CW=54399473900en_HK
dc.identifier.scopusauthoridWong, GH=24465754400en_HK
dc.identifier.scopusauthoridChung, DW=7401719312en_HK
dc.identifier.scopusauthoridTso, S=25229476600en_HK
dc.identifier.scopusauthoridChan, KP=16204769300en_HK
dc.identifier.scopusauthoridYip, KC=28168097100en_HK
dc.identifier.scopusauthoridHung, SF=7201936267en_HK
dc.identifier.scopusauthoridHoner, WG=7004460814en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats