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Article: Persistent negative symptoms in first-episode schizophrenia: A prospective three-year follow-up study

TitlePersistent negative symptoms in first-episode schizophrenia: A prospective three-year follow-up study
Authors
KeywordsCourse
First-episode schizophrenia
Outcome
Persistent primary negative symptoms
Stability
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2011, v. 133 n. 1-3, p. 22-28 How to Cite?
AbstractBackground: Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. Method: Ninety-three Hong Kong Chinese aged 18 to 55. years presenting with first-episode schizophrenia-spectrum disorder were studied. Data on premorbid adjustment, socio-demographics, and baseline clinical and cognitive profiles were obtained. Psychopathological and vocational reassessments were conducted at 12, 24 and 36. months. Primary negative symptoms were defined as the presence of clinically significant negative symptoms excluding depression and extra-pyramidal signs. Results: At baseline, 25.8% of subjects exhibited primary negative symptoms. A quarter of patients had their initial primary negative symptoms status retained 12. months after treatment initiation. In both Year 2 and Year 3 of study period, around 70% of subjects had their primary negative symptoms status maintained for 12. months. At the end of three-year follow-up, 23.7% were categorized as having persistent primary negative symptoms. Male sex, unemployment at intake, prolonged duration of untreated psychosis, poorer premorbid academic and social functioning, poorer insight and worse vocational outcome were found to be associated with persistent primary negative symptoms. Conclusion: Clinical status of primary negative symptoms in first-episode schizophrenia-spectrum disorder was unstable in the initial year of treatment. Baseline symptom assessment may not reliably predict development of persistent primary negative symptoms. Studying negative symptoms should take into account the longitudinal perspective, especially in the early course of psychotic disorders. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/146905
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong21500.10202404
Janssen-Cilag
Astra-Zeneca
Eli Lilly
Sanofi-Aventis
Otsuka
Funding Information:

This work was supported by grant 21500.10202404 from the Research Grants Council of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorChang, WCen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-05-23T05:49:16Z-
dc.date.available2012-05-23T05:49:16Z-
dc.date.issued2011en_HK
dc.identifier.citationSchizophrenia Research, 2011, v. 133 n. 1-3, p. 22-28en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146905-
dc.description.abstractBackground: Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. Method: Ninety-three Hong Kong Chinese aged 18 to 55. years presenting with first-episode schizophrenia-spectrum disorder were studied. Data on premorbid adjustment, socio-demographics, and baseline clinical and cognitive profiles were obtained. Psychopathological and vocational reassessments were conducted at 12, 24 and 36. months. Primary negative symptoms were defined as the presence of clinically significant negative symptoms excluding depression and extra-pyramidal signs. Results: At baseline, 25.8% of subjects exhibited primary negative symptoms. A quarter of patients had their initial primary negative symptoms status retained 12. months after treatment initiation. In both Year 2 and Year 3 of study period, around 70% of subjects had their primary negative symptoms status maintained for 12. months. At the end of three-year follow-up, 23.7% were categorized as having persistent primary negative symptoms. Male sex, unemployment at intake, prolonged duration of untreated psychosis, poorer premorbid academic and social functioning, poorer insight and worse vocational outcome were found to be associated with persistent primary negative symptoms. Conclusion: Clinical status of primary negative symptoms in first-episode schizophrenia-spectrum disorder was unstable in the initial year of treatment. Baseline symptom assessment may not reliably predict development of persistent primary negative symptoms. Studying negative symptoms should take into account the longitudinal perspective, especially in the early course of psychotic disorders. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCourseen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectOutcomeen_HK
dc.subjectPersistent primary negative symptomsen_HK
dc.subjectStabilityen_HK
dc.subject.meshBehavioral Symptoms - etiology - psychology - therapy-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshSchizophrenia - complications - diagnosis - epidemiology - therapy-
dc.subject.meshSchizophrenic Psychology-
dc.titlePersistent negative symptoms in first-episode schizophrenia: A prospective three-year follow-up studyen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, WC: changwc@hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChang, WC=rp01465en_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2011.09.006en_HK
dc.identifier.pmid21968080-
dc.identifier.scopuseid_2-s2.0-81955167927en_HK
dc.identifier.hkuros199750en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81955167927&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage22en_HK
dc.identifier.epage28en_HK
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000298512500005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChang, WC=26643706700en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridTang, JYM=35086815700en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridChan, SKW=55039018700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike9858097-

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