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Article: Longitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: A 3-year follow-up study

TitleLongitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: A 3-year follow-up study
Authors
KeywordsCategorization
First episode
Schizophrenia
Semantic
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2012, v. 137 n. 1-3, p. 118-123 How to Cite?
Abstract
Semantic categorization abnormalities have been observed in schizophrenia, but studies have rarely focused on the longitudinal trajectory. In this study, we consider semantic performance and the relationship with symptomatic changes during recovery from a first-episode of schizophrenia over a period of 3. years. Thirty-seven first-episode patients with schizophrenia were compared to thirty-seven matched controls in a categorization task. Patients were assessed at first episode, after clinical stabilization, and annually for the subsequent 3. years. In the task, participants indicated whether a word belonged to a given category. Each category contained words of varying degrees of semantic relatedness: typical, atypical, borderline, related-but-outside, and unrelated. Reaction times and proportion of 'yes' responses were analyzed. At first assessment, semantic categorization abnormalities were observed in first-episode patients. Patients assigned more semantically-dissimilar words to the categories than controls. As patients stabilized from acute states, their semantic categorization performance improved and then remained stable throughout the entire follow up period of 3. years. Interestingly, semantic performance deficits, particularly a diminished typicality effect, correlated with negative symptoms in the initial episode, but not at stabilization when symptoms subsided. No significant associations between positive and negative symptoms, or pre-defined categorization measures were identified. The data demonstrated semantic memory abnormalities in first-episode schizophrenia. However, an improvement of semantic categorization performance was observed in stabilized schizophrenia patients. Overall, the data are suggestive of a state effect in semantic abnormalities rather than a trait effect. The correlation between degree of impairment and symptoms may explain previous inconsistent findings. © 2012 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/146904
ISSN
2013 Impact Factor: 4.426
2013 SCImago Journal Rankings: 3.163
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong21500.10202404
Janssen-Cilag
AstraZeneca
Pfizer
Eli Lilly
Sanofi-Aventis
Otsuka
Funding Information:

This work was supported by grant 21500.10202404 from the Research Grants Council of Hong Kong. The Institutional Review Board ethics committees of the University of Hong Kong/ Hospital Authority Hong Kong West Cluster and Hong Kong East Cluster approved the study.

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Pamela Youde Nethersole Eastern Hospital
DC FieldValueLanguage
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorLongenecker, Jen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorChang, WCen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorLee, EHMen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorMiao, MYKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorTang, WNen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-05-23T05:49:15Z-
dc.date.available2012-05-23T05:49:15Z-
dc.date.issued2012en_HK
dc.identifier.citationSchizophrenia Research, 2012, v. 137 n. 1-3, p. 118-123en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146904-
dc.description.abstractSemantic categorization abnormalities have been observed in schizophrenia, but studies have rarely focused on the longitudinal trajectory. In this study, we consider semantic performance and the relationship with symptomatic changes during recovery from a first-episode of schizophrenia over a period of 3. years. Thirty-seven first-episode patients with schizophrenia were compared to thirty-seven matched controls in a categorization task. Patients were assessed at first episode, after clinical stabilization, and annually for the subsequent 3. years. In the task, participants indicated whether a word belonged to a given category. Each category contained words of varying degrees of semantic relatedness: typical, atypical, borderline, related-but-outside, and unrelated. Reaction times and proportion of 'yes' responses were analyzed. At first assessment, semantic categorization abnormalities were observed in first-episode patients. Patients assigned more semantically-dissimilar words to the categories than controls. As patients stabilized from acute states, their semantic categorization performance improved and then remained stable throughout the entire follow up period of 3. years. Interestingly, semantic performance deficits, particularly a diminished typicality effect, correlated with negative symptoms in the initial episode, but not at stabilization when symptoms subsided. No significant associations between positive and negative symptoms, or pre-defined categorization measures were identified. The data demonstrated semantic memory abnormalities in first-episode schizophrenia. However, an improvement of semantic categorization performance was observed in stabilized schizophrenia patients. Overall, the data are suggestive of a state effect in semantic abnormalities rather than a trait effect. The correlation between degree of impairment and symptoms may explain previous inconsistent findings. © 2012 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCategorizationen_HK
dc.subjectFirst episodeen_HK
dc.subjectSchizophreniaen_HK
dc.subjectSemanticen_HK
dc.titleLongitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: A 3-year follow-up studyen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, WC: changwc@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChang, WC=rp01465en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2012.02.010en_HK
dc.identifier.pmid22449835-
dc.identifier.scopuseid_2-s2.0-84863394865en_HK
dc.identifier.hkuros199748en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863394865&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage118en_HK
dc.identifier.epage123en_HK
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000303933800018-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridLongenecker, J=35275177400en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridTang, JYM=55234907400en_HK
dc.identifier.scopusauthoridChang, WC=26643706700en_HK
dc.identifier.scopusauthoridChan, SKW=55039018700en_HK
dc.identifier.scopusauthoridLee, EHM=55290606300en_HK
dc.identifier.scopusauthoridDunn, ELW=8610805000en_HK
dc.identifier.scopusauthoridMiao, MYK=8610805100en_HK
dc.identifier.scopusauthoridYeung, WS=55290291300en_HK
dc.identifier.scopusauthoridWong, CK=36862848100en_HK
dc.identifier.scopusauthoridChan, WF=8610805400en_HK
dc.identifier.scopusauthoridTang, WN=8610805700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike10513738-

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