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Conference Paper: Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and endothelial progenitor cell mobilisation in mice
| Title | Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and endothelial progenitor cell mobilisation in mice |
|---|---|
| Authors | |
| Issue Date | 2012 |
| Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk |
| Citation | The 17th Medical Research Conference (MRC 2012), Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 37, abstract no. 50 How to Cite? |
| Abstract | INTRODUCTION: Vascular dysfunction is commonly observed in diabetic patients. Endothelial injury can be repaired in part by endothelial progenitor cells (EPCs). In diabetes, impaired functionality and reduced number of EPCs are reported. AMP-activated kinase (AMPK) is a well-known target of several anti-diabetic and cardiovascular drugs. The objective of this study was to examine whether the activation of AMPK in endothelium alone is sufficient to prevent diabetes-induced impairment in vascular function, possibly by improving EPC function and endothelial repair using a tissue-specific transgenic mouse model. METHODS: Transgenic mice with endothelium-selective expression of a … |
| Description | This journal supplement contains abstracts from the 17th MRC; Dept. of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Topics: Basic science, translational and clinical research Oral Presentation |
| Persistent Identifier | http://hdl.handle.net/10722/146021 |
| ISSN | 2021 Impact Factor: 1.256 2020 SCImago Journal Rankings: 0.357 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, FYL | en_US |
| dc.contributor.author | Wang, Y | en_US |
| dc.contributor.author | Lam, KSL | en_US |
| dc.contributor.author | Xu, A | en_US |
| dc.date.accessioned | 2012-03-27T09:06:17Z | - |
| dc.date.available | 2012-03-27T09:06:17Z | - |
| dc.date.issued | 2012 | en_US |
| dc.identifier.citation | The 17th Medical Research Conference (MRC 2012), Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 37, abstract no. 50 | en_US |
| dc.identifier.issn | 1024-2708 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/146021 | - |
| dc.description | This journal supplement contains abstracts from the 17th MRC; Dept. of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong | - |
| dc.description | Topics: Basic science, translational and clinical research | - |
| dc.description | Oral Presentation | - |
| dc.description.abstract | INTRODUCTION: Vascular dysfunction is commonly observed in diabetic patients. Endothelial injury can be repaired in part by endothelial progenitor cells (EPCs). In diabetes, impaired functionality and reduced number of EPCs are reported. AMP-activated kinase (AMPK) is a well-known target of several anti-diabetic and cardiovascular drugs. The objective of this study was to examine whether the activation of AMPK in endothelium alone is sufficient to prevent diabetes-induced impairment in vascular function, possibly by improving EPC function and endothelial repair using a tissue-specific transgenic mouse model. METHODS: Transgenic mice with endothelium-selective expression of a … | - |
| dc.language | eng | en_US |
| dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk | - |
| dc.relation.ispartof | Hong Kong Medical Journal | en_US |
| dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press. | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.title | Endothelium-selective activation of AMP-activated protein kinase alleviates diabetes-induced endothelial dysfunction by enhancing reendothelialisation and endothelial progenitor cell mobilisation in mice | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Li, FYL: francois.li@hku.hk | en_US |
| dc.identifier.email | Wang, Y: yiqunw@hku.hk | en_US |
| dc.identifier.email | Lam, KSL: ksllam@hku.hk | en_US |
| dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_US |
| dc.identifier.authority | Lam, KSL=rp00343 | en_US |
| dc.identifier.authority | Xu, A=rp00485 | en_US |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.hkuros | 198910 | en_US |
| dc.identifier.volume | 18 | - |
| dc.identifier.issue | suppl. 1 | - |
| dc.identifier.spage | 37, abstract no. 50 | - |
| dc.identifier.epage | 37, abstract no. 50 | - |
| dc.publisher.place | Hong Kong | - |
| dc.description.other | The 17th Medical Research Conference (MRC), Department of Medicine, University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 37, abstract no. 50 | - |
| dc.identifier.issnl | 1024-2708 | - |