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Conference Paper: A Genome-wide Association Study Identifies a New Genetic Susceptibility Factor for Kawasaki Disease

TitleA Genome-wide Association Study Identifies a New Genetic Susceptibility Factor for Kawasaki Disease
Authors
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
Citation
The 10th International Kawasaki Disease Symposium, Kyoto, Japan, 7-10 February 2012. In Pediatrics International, 2012, v. 54 n. Suppl. 1, p. 45-46, abstract no. O-22 How to Cite?
Abstract
We performed a case-control GWAS on KD, initially analyzing 494,236 genetic markers in a total of 405 KD cases of European descent matched to 6,252 controls. The independent replication sample set included an additional 1,768 KD cases of European- Caucasian and Asian descent and 3,131 family and population controls in aggregate. The total sample size of 2,173 KD cases and 9,383 controls was assembled by team members from different nations and research networks. Single-SNP analysis for association with KD susceptibility was performed using logistic regression fi tted for genotype trend effects (1 degree of freedom), with adjustment for the top four principal components of population ancestry. We attempted replication of the 62 most signifi cantly associated SNPs in a family-based sample collection of 760 complete parent-offspring trios and 139 discordant sibling pairs using the Sequenom Mass-Array genotyping platform. A total of 5 SNPs showed a consistent direction of effect with the GWAS (1.96 × 10−3 < P < 0.068) in the family-based analysis. Combined analysis of both the GWAS and family-based tests for these 5 SNPs resulted in four exceeding P < 1.0 × 10−5 and representing four distinct genetic loci. We then followed up these SNPs in three Asian collections comprising 438 KD cases vs. 446 controls from Taiwan, 460 KD cases vs. 498 controls from Korea, and 130 KD cases vs. 568 controls from Hong Kong and Shanghai. The specifi c loci and possible functional implications for understanding the immune activation of KD pathogenesis will be discussed.
DescriptionConference theme: From Genetics to Clinics
Persistent Identifierhttp://hdl.handle.net/10722/145609
ISSN
2013 Impact Factor: 0.731
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDavila, Sen_US
dc.contributor.authorKhor, CCen_US
dc.contributor.authorBreunis, WBen_US
dc.contributor.authorLee, YCen_US
dc.contributor.authorShimizu, Cen_US
dc.contributor.authorWright, VJen_US
dc.contributor.authorYeung, RSen_US
dc.contributor.authorTan, DEKen_US
dc.contributor.authorSim, KSen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorPang, Men_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorCimaz, Ren_US
dc.contributor.authorDahdah, Nen_US
dc.contributor.authorCheung, YFen_US
dc.contributor.authorHuang, GYen_US
dc.contributor.authorYang, Wen_US
dc.contributor.authorPark, ISen_US
dc.contributor.authorLee, JKen_US
dc.contributor.authorWu, JYen_US
dc.contributor.authorLevin, Men_US
dc.contributor.authorBurns, JCen_US
dc.contributor.authorBurgner, Den_US
dc.contributor.authorKuijpers, TWen_US
dc.contributor.authorHibberd, MLen_US
dc.date.accessioned2012-02-28T01:58:07Z-
dc.date.available2012-02-28T01:58:07Z-
dc.date.issued2012en_US
dc.identifier.citationThe 10th International Kawasaki Disease Symposium, Kyoto, Japan, 7-10 February 2012. In Pediatrics International, 2012, v. 54 n. Suppl. 1, p. 45-46, abstract no. O-22en_US
dc.identifier.issn1328-8067-
dc.identifier.urihttp://hdl.handle.net/10722/145609-
dc.descriptionConference theme: From Genetics to Clinics-
dc.descriptionSesssion: Genetics-
dc.description.abstractWe performed a case-control GWAS on KD, initially analyzing 494,236 genetic markers in a total of 405 KD cases of European descent matched to 6,252 controls. The independent replication sample set included an additional 1,768 KD cases of European- Caucasian and Asian descent and 3,131 family and population controls in aggregate. The total sample size of 2,173 KD cases and 9,383 controls was assembled by team members from different nations and research networks. Single-SNP analysis for association with KD susceptibility was performed using logistic regression fi tted for genotype trend effects (1 degree of freedom), with adjustment for the top four principal components of population ancestry. We attempted replication of the 62 most signifi cantly associated SNPs in a family-based sample collection of 760 complete parent-offspring trios and 139 discordant sibling pairs using the Sequenom Mass-Array genotyping platform. A total of 5 SNPs showed a consistent direction of effect with the GWAS (1.96 × 10−3 < P < 0.068) in the family-based analysis. Combined analysis of both the GWAS and family-based tests for these 5 SNPs resulted in four exceeding P < 1.0 × 10−5 and representing four distinct genetic loci. We then followed up these SNPs in three Asian collections comprising 438 KD cases vs. 446 controls from Taiwan, 460 KD cases vs. 498 controls from Korea, and 130 KD cases vs. 568 controls from Hong Kong and Shanghai. The specifi c loci and possible functional implications for understanding the immune activation of KD pathogenesis will be discussed.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED-
dc.relation.ispartofPediatrics Internationalen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.titleA Genome-wide Association Study Identifies a New Genetic Susceptibility Factor for Kawasaki Diseaseen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, YF: xfcheung@hku.hken_US
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.identifier.authorityYang, W=rp00524en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1442-200X.2012.03534.x-
dc.identifier.hkuros198737en_US
dc.identifier.volume54-
dc.identifier.issueSuppl. 1-
dc.identifier.spage45, abstract no. O-22-
dc.identifier.epage46, abstract no. O-22-
dc.identifier.isiWOS:000299822300001-
dc.publisher.placeAustralia-

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