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Conference Paper: Left Ventricular Mechanics in Patients with a History of Kawasaki Disease: Analysis by 3-Dimensional Speckle Tracking Echocardiography

TitleLeft Ventricular Mechanics in Patients with a History of Kawasaki Disease: Analysis by 3-Dimensional Speckle Tracking Echocardiography
Authors
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
Citation
The 10th International Kawasaki Disease Symposium, Kyoto, Japan, 7-10 February 2012. In Pediatrics International, 2012, v. 54 n. Suppl. 1, p. 90-91, abstract no. P-89 How to Cite?
AbstractBackground Myocardial fi brosis and perfusion abnormalities suggestive of myocardial ischemia can occur in patients with a history of Kawasaki disease (KD). We tested the hypothesis that children and adolescents with a history of KD have long-term abnormalities in left ventricular (LV) mechanics. Methods 14 KD patients (10 males), aged 18.0 ± 5.7 years, with coronary aneurysms were studied using a novel 3D speckle tracking echocardiography technique. The 3D volume datasets were acquired for quantifi cation of LV global 3D strain, systolic dyssynchrony index (SDI), twist, twist gradient (twist/LV length), and ejection fraction. The results were compared with those of 14 age-matched controls. Results Of the 14 patients, 6 had left, 2 had right, and 6 had both left and right coronary aneurysms. As compared with controls, patients had signifi cantly lower LV systolic global 3D strain (43.7 ± 7.3% vs 49.7 ± 7.6%, p = 0.04), twist (8.7 ± 1.3 deg vs 11.4 ± 2.0 deg, p < 0.001), and twist gradient (1.5 ± 0.3 deg/ cm vs 1.9 ± 0.4 deg/cm, p = 0.01), greater SDI (6.8 ± 1.9% vs 5.4 ± 1.1%, p = 0.03), and similar ejection fractions. Five patients had perfusion defects, but the parameters of 3D LV mechanics among these patients were similar to those of the 9 patients without perfusion abnormalities. Conclusions Late abnormalities of LV mechanics occur in KD patients with coronary aneurysms, even in the absence of perfusion abnormalities.
DescriptionConference theme: From Genetics to Clinics
Poster Session 3: Cardiovascular Imaging
Persistent Identifierhttp://hdl.handle.net/10722/145608
ISSN
2015 Impact Factor: 0.868
2015 SCImago Journal Rankings: 0.424

 

DC FieldValueLanguage
dc.contributor.authorYu, Wen_US
dc.contributor.authorWong, SJen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-02-28T01:58:05Z-
dc.date.available2012-02-28T01:58:05Z-
dc.date.issued2012en_US
dc.identifier.citationThe 10th International Kawasaki Disease Symposium, Kyoto, Japan, 7-10 February 2012. In Pediatrics International, 2012, v. 54 n. Suppl. 1, p. 90-91, abstract no. P-89en_US
dc.identifier.issn1328-8067-
dc.identifier.urihttp://hdl.handle.net/10722/145608-
dc.descriptionConference theme: From Genetics to Clinics-
dc.descriptionPoster Session 3: Cardiovascular Imaging-
dc.description.abstractBackground Myocardial fi brosis and perfusion abnormalities suggestive of myocardial ischemia can occur in patients with a history of Kawasaki disease (KD). We tested the hypothesis that children and adolescents with a history of KD have long-term abnormalities in left ventricular (LV) mechanics. Methods 14 KD patients (10 males), aged 18.0 ± 5.7 years, with coronary aneurysms were studied using a novel 3D speckle tracking echocardiography technique. The 3D volume datasets were acquired for quantifi cation of LV global 3D strain, systolic dyssynchrony index (SDI), twist, twist gradient (twist/LV length), and ejection fraction. The results were compared with those of 14 age-matched controls. Results Of the 14 patients, 6 had left, 2 had right, and 6 had both left and right coronary aneurysms. As compared with controls, patients had signifi cantly lower LV systolic global 3D strain (43.7 ± 7.3% vs 49.7 ± 7.6%, p = 0.04), twist (8.7 ± 1.3 deg vs 11.4 ± 2.0 deg, p < 0.001), and twist gradient (1.5 ± 0.3 deg/ cm vs 1.9 ± 0.4 deg/cm, p = 0.01), greater SDI (6.8 ± 1.9% vs 5.4 ± 1.1%, p = 0.03), and similar ejection fractions. Five patients had perfusion defects, but the parameters of 3D LV mechanics among these patients were similar to those of the 9 patients without perfusion abnormalities. Conclusions Late abnormalities of LV mechanics occur in KD patients with coronary aneurysms, even in the absence of perfusion abnormalities.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED-
dc.relation.ispartofPediatrics Internationalen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.titleLeft Ventricular Mechanics in Patients with a History of Kawasaki Disease: Analysis by 3-Dimensional Speckle Tracking Echocardiographyen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, SJ: sjwong@hku.hken_US
dc.identifier.emailCheung, YF: xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1442-200X.2012.03535.x-
dc.identifier.hkuros198736en_US
dc.identifier.volume54-
dc.identifier.issueSuppl. 1-
dc.identifier.spage90, abstract no. P-89-
dc.identifier.epage91, abstract no. P-89-
dc.publisher.placeAustralia-

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