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Article: Physical activity for cancer survivors: meta-analysis of randomised controlled trials.

TitlePhysical activity for cancer survivors: meta-analysis of randomised controlled trials.
Authors
Issue Date2012
PublisherBMJ Group. The Journal's web site is located at http://www.bmj.com/
Citation
Bmj (Clinical Research Ed.), 2012, v. 344, p. e70 How to Cite?
AbstractTo systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. Pubmed, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.
Persistent Identifierhttp://hdl.handle.net/10722/145588
ISSN
2015 Impact Factor: 19.697
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
World Cancer Research Fund International
World Cancer Research Fund UK
World Cancer Research Fund Hong Kong2009/02
Funding Information:

This study was supported by the World Cancer Research Fund International, World Cancer Research Fund UK, and World Cancer Research Fund Hong Kong (grant No 2009/02). The funding body had no input in study design and the collection, analysis, and interpretation of data and the writing of the article and the decision to submit it for publication. All authors are independent from the funding body.

References

 

DC FieldValueLanguage
dc.contributor.authorFong, DYen_HK
dc.contributor.authorHo, JWen_HK
dc.contributor.authorHui, BPen_HK
dc.contributor.authorLee, AMen_HK
dc.contributor.authorMacfarlane, DJen_HK
dc.contributor.authorLeung, SSen_HK
dc.contributor.authorCerin, Een_HK
dc.contributor.authorChan, WYen_HK
dc.contributor.authorLeung, IPen_HK
dc.contributor.authorLam, SHen_HK
dc.contributor.authorTaylor, AJen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2012-02-28T01:56:05Z-
dc.date.available2012-02-28T01:56:05Z-
dc.date.issued2012en_HK
dc.identifier.citationBmj (Clinical Research Ed.), 2012, v. 344, p. e70en_HK
dc.identifier.issn1756-1833en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145588-
dc.description.abstractTo systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. Pubmed, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.en_HK
dc.languageengen_US
dc.publisherBMJ Group. The Journal's web site is located at http://www.bmj.com/-
dc.relation.ispartofBMJ (Clinical research ed.)en_HK
dc.rightsBMJ. Copyright © BMJ Group.-
dc.rightsLocked and research funded articles acknowledgement: This article has been accepted for publication in BMJ. The definitive copyedited, typeset version BMJ, 2012, v. 344, article no. e70 is available online at: www. http://www.bmj.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBreast Neoplasms - epidemiology - psychology - rehabilitation-
dc.subject.meshExercise - physiology - psychology-
dc.subject.meshOutcome Assessment (Health Care) - statistics and numerical data-
dc.subject.meshQuality of Life-
dc.subject.meshSurvivors - statistics and numerical data-
dc.titlePhysical activity for cancer survivors: meta-analysis of randomised controlled trials.en_HK
dc.typeArticleen_HK
dc.identifier.emailFong, DY: dytfong@hku.hken_HK
dc.identifier.emailMacfarlane, DJ: djmac@hku.hken_HK
dc.identifier.emailLeung, SS: sleung@hkucc.hku.hken_HK
dc.identifier.emailCerin, E: ecerin@hku.hken_HK
dc.identifier.authorityFong, DY=rp00253en_HK
dc.identifier.authorityMacfarlane, DJ=rp00934en_HK
dc.identifier.authorityLeung, SS=rp00493en_HK
dc.identifier.authorityCerin, E=rp00890en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bmj.e70en_HK
dc.identifier.pmid22294757-
dc.identifier.pmcidPMC3269661-
dc.identifier.scopuseid_2-s2.0-84857211646en_HK
dc.identifier.hkuros198672en_US
dc.identifier.hkuros225061-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857211646&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume344en_HK
dc.identifier.issue7844en_HK
dc.identifier.spagee70en_HK
dc.identifier.epagee70en_HK
dc.identifier.eissn1756-1833-
dc.identifier.isiWOS:000300087900002-
dc.publisher.placeUnited Kingdom-
dc.identifier.scopusauthoridFong, DY=35261710300en_HK
dc.identifier.scopusauthoridHo, JW=7402649983en_HK
dc.identifier.scopusauthoridHui, BP=55003173900en_HK
dc.identifier.scopusauthoridLee, AM=36985990500en_HK
dc.identifier.scopusauthoridMacfarlane, DJ=7202978517en_HK
dc.identifier.scopusauthoridLeung, SS=7202044879en_HK
dc.identifier.scopusauthoridCerin, E=14522064200en_HK
dc.identifier.scopusauthoridChan, WY=55095555100en_HK
dc.identifier.scopusauthoridLeung, IP=55094874800en_HK
dc.identifier.scopusauthoridLam, SH=55006769400en_HK
dc.identifier.scopusauthoridTaylor, AJ=15726800800en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK

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