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Article: Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years

TitleEvaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years
Authors
KeywordsAdiponectin
Biomarker
C-reactive protein
Glycaemia
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 2011, v. 54 n. 10, p. 2552-2560 How to Cite?
AbstractAims/hypothesis: Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years. Methods: In total 1,288 non-diabetic participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, with high-sensitivity CRP (hsCRP) and total adiponectin levels measured were included. OGTT was performed in all participants. Two hundred and six participants had deterioration of glycaemia at follow-up, whereas 1,082 participants did not. Results: Baseline age, hsCRP and adiponectin levels were significant independent predictors of the deterioration of glycaemia in a Cox regression analysis after adjusting for baseline age, sex, BMI, hypertension, triacylglycerols, 2 h post-OGTT glucose and homeostasis model assessment of insulin resistance index (all p < 0.01). The introduction of hsCRP or adiponectin level to a regression model including the other biomarker improved the prediction of glycaemic progression significantly in all participants, especially in women (all p < 0.01). The combined inclusion of the two biomarkers resulted in a modest improvement in model discrimination, compared with the inclusion of either one alone. Among participants with impaired fasting glucose/impaired glucose tolerance (IFG/IGT) at baseline, hsCRP and adiponectin levels were not predictive of progression or improvement of glycaemic status. Conclusions/interpretation: Adiponectin and hsCRP levels are independent factors in predicting the deterioration of glycaemia, supporting the role of adiposity-related inflammation in the development of type 2 diabetes. Their combined use as predictive biomarkers is especially useful in women, but not in participants with IFG/IGT. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/145104
ISSN
2014 Impact Factor: 6.671
2014 SCImago Journal Rankings: 2.698
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01 M
HKU7626/07 M
Sun Chieh Yeh Heart Foundation
National Health and Medical Research Council of Australia482800
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01 M and HKU7626/07 M) and the Sun Chieh Yeh Heart Foundation. K. L. Ong was supported by a grant from the National Health and Medical Research Council of Australia (grant 482800).

References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorRye, KAen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2012-02-21T05:44:42Z-
dc.date.available2012-02-21T05:44:42Z-
dc.date.issued2011en_HK
dc.identifier.citationDiabetologia, 2011, v. 54 n. 10, p. 2552-2560en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/145104-
dc.description.abstractAims/hypothesis: Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years. Methods: In total 1,288 non-diabetic participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, with high-sensitivity CRP (hsCRP) and total adiponectin levels measured were included. OGTT was performed in all participants. Two hundred and six participants had deterioration of glycaemia at follow-up, whereas 1,082 participants did not. Results: Baseline age, hsCRP and adiponectin levels were significant independent predictors of the deterioration of glycaemia in a Cox regression analysis after adjusting for baseline age, sex, BMI, hypertension, triacylglycerols, 2 h post-OGTT glucose and homeostasis model assessment of insulin resistance index (all p < 0.01). The introduction of hsCRP or adiponectin level to a regression model including the other biomarker improved the prediction of glycaemic progression significantly in all participants, especially in women (all p < 0.01). The combined inclusion of the two biomarkers resulted in a modest improvement in model discrimination, compared with the inclusion of either one alone. Among participants with impaired fasting glucose/impaired glucose tolerance (IFG/IGT) at baseline, hsCRP and adiponectin levels were not predictive of progression or improvement of glycaemic status. Conclusions/interpretation: Adiponectin and hsCRP levels are independent factors in predicting the deterioration of glycaemia, supporting the role of adiposity-related inflammation in the development of type 2 diabetes. Their combined use as predictive biomarkers is especially useful in women, but not in participants with IFG/IGT. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.relation.ispartofDiabetologiaen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAdiponectinen_HK
dc.subjectBiomarkeren_HK
dc.subjectC-reactive proteinen_HK
dc.subjectGlycaemiaen_HK
dc.titleEvaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 yearsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years&title=Diabetologia&issn=0012186X&date=2011-10-01&volume=54&issue=10& spage=2552&authors=K. L. Ong, A. W. K. Tso, A. Xu, <i>et al.</i>en_US
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00125-011-2227-0en_HK
dc.identifier.pmid21727999-
dc.identifier.pmcidPMC3168746-
dc.identifier.scopuseid_2-s2.0-80054100377en_HK
dc.identifier.hkuros190891-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054100377&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2552en_HK
dc.identifier.epage2560en_HK
dc.identifier.eissn1432-0428en_US
dc.identifier.isiWOS:000294683000011-
dc.publisher.placeGermanyen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridLi, M=54079879500en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridRye, KA=7006700031en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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