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Article: Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years
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TitleEvaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years
 
AuthorsOng, KL1 3
Tso, AWK1
Xu, A1
Law, LSC1
Li, M2
Wat, NMS1
Rye, KA3
Lam, TH1
Cheung, BMY1
Lam, KSL1
 
KeywordsAdiponectin
Biomarker
C-reactive protein
Glycaemia
 
Issue Date2011
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
 
CitationDiabetologia, 2011, v. 54 n. 10, p. 2552-2560 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00125-011-2227-0
 
AbstractAims/hypothesis: Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years. Methods: In total 1,288 non-diabetic participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, with high-sensitivity CRP (hsCRP) and total adiponectin levels measured were included. OGTT was performed in all participants. Two hundred and six participants had deterioration of glycaemia at follow-up, whereas 1,082 participants did not. Results: Baseline age, hsCRP and adiponectin levels were significant independent predictors of the deterioration of glycaemia in a Cox regression analysis after adjusting for baseline age, sex, BMI, hypertension, triacylglycerols, 2 h post-OGTT glucose and homeostasis model assessment of insulin resistance index (all p < 0.01). The introduction of hsCRP or adiponectin level to a regression model including the other biomarker improved the prediction of glycaemic progression significantly in all participants, especially in women (all p < 0.01). The combined inclusion of the two biomarkers resulted in a modest improvement in model discrimination, compared with the inclusion of either one alone. Among participants with impaired fasting glucose/impaired glucose tolerance (IFG/IGT) at baseline, hsCRP and adiponectin levels were not predictive of progression or improvement of glycaemic status. Conclusions/interpretation: Adiponectin and hsCRP levels are independent factors in predicting the deterioration of glycaemia, supporting the role of adiposity-related inflammation in the development of type 2 diabetes. Their combined use as predictive biomarkers is especially useful in women, but not in participants with IFG/IGT. © 2011 The Author(s).
 
ISSN0012-186X
2013 Impact Factor: 6.880
 
DOIhttp://dx.doi.org/10.1007/s00125-011-2227-0
 
PubMed Central IDPMC3168746
 
ISI Accession Number IDWOS:000294683000011
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01 M
HKU7626/07 M
Sun Chieh Yeh Heart Foundation
National Health and Medical Research Council of Australia482800
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01 M and HKU7626/07 M) and the Sun Chieh Yeh Heart Foundation. K. L. Ong was supported by a grant from the National Health and Medical Research Council of Australia (grant 482800).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorXu, A
 
dc.contributor.authorLaw, LSC
 
dc.contributor.authorLi, M
 
dc.contributor.authorWat, NMS
 
dc.contributor.authorRye, KA
 
dc.contributor.authorLam, TH
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2012-02-21T05:44:42Z
 
dc.date.available2012-02-21T05:44:42Z
 
dc.date.issued2011
 
dc.description.abstractAims/hypothesis: Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years. Methods: In total 1,288 non-diabetic participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, with high-sensitivity CRP (hsCRP) and total adiponectin levels measured were included. OGTT was performed in all participants. Two hundred and six participants had deterioration of glycaemia at follow-up, whereas 1,082 participants did not. Results: Baseline age, hsCRP and adiponectin levels were significant independent predictors of the deterioration of glycaemia in a Cox regression analysis after adjusting for baseline age, sex, BMI, hypertension, triacylglycerols, 2 h post-OGTT glucose and homeostasis model assessment of insulin resistance index (all p < 0.01). The introduction of hsCRP or adiponectin level to a regression model including the other biomarker improved the prediction of glycaemic progression significantly in all participants, especially in women (all p < 0.01). The combined inclusion of the two biomarkers resulted in a modest improvement in model discrimination, compared with the inclusion of either one alone. Among participants with impaired fasting glucose/impaired glucose tolerance (IFG/IGT) at baseline, hsCRP and adiponectin levels were not predictive of progression or improvement of glycaemic status. Conclusions/interpretation: Adiponectin and hsCRP levels are independent factors in predicting the deterioration of glycaemia, supporting the role of adiposity-related inflammation in the development of type 2 diabetes. Their combined use as predictive biomarkers is especially useful in women, but not in participants with IFG/IGT. © 2011 The Author(s).
 
dc.description.naturepublished_or_final_version
 
dc.description.otherSpringer Open Choice, 21 Feb 2012
 
dc.identifier.citationDiabetologia, 2011, v. 54 n. 10, p. 2552-2560 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00125-011-2227-0
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00125-011-2227-0
 
dc.identifier.eissn1432-0428
 
dc.identifier.epage2560
 
dc.identifier.hkuros190891
 
dc.identifier.isiWOS:000294683000011
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01 M
HKU7626/07 M
Sun Chieh Yeh Heart Foundation
National Health and Medical Research Council of Australia482800
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01 M and HKU7626/07 M) and the Sun Chieh Yeh Heart Foundation. K. L. Ong was supported by a grant from the National Health and Medical Research Council of Australia (grant 482800).

 
dc.identifier.issn0012-186X
2013 Impact Factor: 6.880
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3168746
 
dc.identifier.pmid21727999
 
dc.identifier.scopuseid_2-s2.0-80054100377
 
dc.identifier.spage2552
 
dc.identifier.urihttp://hdl.handle.net/10722/145104
 
dc.identifier.volume54
 
dc.languageEng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofDiabetologia
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe Author(s)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectAdiponectin
 
dc.subjectBiomarker
 
dc.subjectC-reactive protein
 
dc.subjectGlycaemia
 
dc.titleEvaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Nanjing Medical University
  3. Heart Research Institute Australia