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Article: Renal cell carcinoma of native kidney in Chinese renal transplant recipients: A report of 12 cases and a review of the literature

TitleRenal cell carcinoma of native kidney in Chinese renal transplant recipients: A report of 12 cases and a review of the literature
Authors
KeywordsAcquired cystic kidney disease
Chinese
Kidney transplantation
Renal cell carcinoma
Ultrasound
Issue Date2011
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-1623
Citation
International Urology And Nephrology, 2011, v. 43 n. 3, p. 675-680 How to Cite?
AbstractObjectives To present and discuss the epidemiological and clinical aspects, as well as therapeutic options and outcome of de novo renal cell carcinoma (RCC) of the native kidneys in a series of Chinese renal transplant recipients. Patients and Methods A retrospective, cohort study examining all renal transplant recipients with the diagnosis of RCC of native kidney followed up in two major regional hospitals in Hong Kong between January 2000 and December 2009. Clinical data includedage, gender, cause of renal failure, symptoms at presentation, duration of transplantation, immunosuppressive therapy, and history of acquired cystic kidney disease (ACKD). Laboratory, radiographic, operative, and pathology reports were used to assess the tumor extent. Results Among the 1,003 renal transplant recipients recruited, 12 transplant recipients had a nephrectomy for a total of 13 RCC. The prevalence of de novo RCC was 1.3%. The mean age at diagnosis of RCC was 48.4 years, and the median time from transplantation to diagnosis was 6.1 years. ACKD was found in 6 (50%) of the patients. All patients except one were asymptomatic. pT1 disease was found in ten patients with a mean tumor size of 3.2 cm. All patients were treated successfully with radical nephrectomy. After a median follow-up of 38 months, two patients (16.7%) died. One died of sepsis, and the other died of metastatic carcinoma. Conclusions With increasing data showing a better prognosis if RCC is detected early by screening, it is time to consider screening all kidney transplant recipients for ACKD and RCC. © The Author(s) 2011. This article is published with open access at Springerlink.com.
Persistent Identifierhttp://hdl.handle.net/10722/145088
ISSN
2015 Impact Factor: 1.292
2015 SCImago Journal Rankings: 0.506
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorLee, KCen_HK
dc.contributor.authorChan, GSWen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorChau, KFen_HK
dc.contributor.authorLi, CSen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-02-21T05:43:49Z-
dc.date.available2012-02-21T05:43:49Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Urology And Nephrology, 2011, v. 43 n. 3, p. 675-680en_HK
dc.identifier.issn0301-1623en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145088-
dc.description.abstractObjectives To present and discuss the epidemiological and clinical aspects, as well as therapeutic options and outcome of de novo renal cell carcinoma (RCC) of the native kidneys in a series of Chinese renal transplant recipients. Patients and Methods A retrospective, cohort study examining all renal transplant recipients with the diagnosis of RCC of native kidney followed up in two major regional hospitals in Hong Kong between January 2000 and December 2009. Clinical data includedage, gender, cause of renal failure, symptoms at presentation, duration of transplantation, immunosuppressive therapy, and history of acquired cystic kidney disease (ACKD). Laboratory, radiographic, operative, and pathology reports were used to assess the tumor extent. Results Among the 1,003 renal transplant recipients recruited, 12 transplant recipients had a nephrectomy for a total of 13 RCC. The prevalence of de novo RCC was 1.3%. The mean age at diagnosis of RCC was 48.4 years, and the median time from transplantation to diagnosis was 6.1 years. ACKD was found in 6 (50%) of the patients. All patients except one were asymptomatic. pT1 disease was found in ten patients with a mean tumor size of 3.2 cm. All patients were treated successfully with radical nephrectomy. After a median follow-up of 38 months, two patients (16.7%) died. One died of sepsis, and the other died of metastatic carcinoma. Conclusions With increasing data showing a better prognosis if RCC is detected early by screening, it is time to consider screening all kidney transplant recipients for ACKD and RCC. © The Author(s) 2011. This article is published with open access at Springerlink.com.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-1623en_HK
dc.relation.ispartofInternational Urology and Nephrologyen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAcquired cystic kidney diseaseen_HK
dc.subjectChineseen_HK
dc.subjectKidney transplantationen_HK
dc.subjectRenal cell carcinomaen_HK
dc.subjectUltrasounden_HK
dc.titleRenal cell carcinoma of native kidney in Chinese renal transplant recipients: A report of 12 cases and a review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature&title=International Urology and Nephrology&issn=03011623&date=2011-09-01&volume=43&issue=3& spage=675&authors=Chi Yuen Cheung, Man Fai Lam, King Chung Lee, <i>et al.</i>en_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailLai, KN:knlai@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11255-011-9912-2en_HK
dc.identifier.pmid21547472en_HK
dc.identifier.pmcidPMC3160549-
dc.identifier.scopuseid_2-s2.0-80555135431en_HK
dc.identifier.hkuros197012-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80555135431&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue3en_HK
dc.identifier.spage675en_HK
dc.identifier.epage680en_HK
dc.identifier.eissn1573-2584en_US
dc.identifier.isiWOS:000294222500011-
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridCheung, CY=7202061711en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridLee, KC=54380409500en_HK
dc.identifier.scopusauthoridChan, GSW=35749611500en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridChau, KF=7202674672en_HK
dc.identifier.scopusauthoridLi, CS=7409844347en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike8998649-

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