Article: Use of aspirin in Chinese after recovery from primary intracranial haemorrhage

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TitleUse of aspirin in Chinese after recovery from primary intracranial haemorrhage
AuthorsChong, BH
Chan, KH1
Pong, V
Lau, KK1
Chan, YH1
Zuo, ML
Lui, WM1
Leung, GKK1
Lau, CP
Tse, HF
Pu, JKS1
Siu, CW
KeywordsAntiplatelet agents
Risk factors
Stroke/prevention
Issue Date2012
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
CitationThrombosis And Haemostasis, 2012, v. 107 n. 2, p. 241-247 [How to Cite?]
DOI: http://dx.doi.org/10.1160/TH11-06-0439
AbstractIntracranial haemorrhage (ICH) accounts for ∼35% of all strokes in Chinese. Anti-platelet agent is often avoided after an index event due to the possibility of recurrent ICH. This single-centered observational study included 440 consecutive Chinese patients with a first spontaneous ICH surviving the first month performed during 1996-2010. The subjects were identified, and their clinical characteristics, anti-platelet therapy after ICH, and outcomes including recurrent ICH, ischaemic stroke, and acute coronary syndrome were checked from hospital records. Of these 440 patients, 56 patients (12.7%) were prescribed aspirin (312 patientaspirin years). After a follow-up of 62.2 ± 1.8 months, 47 patients had recurrent ICH (10.7%, 20.6 per 1,000 patient years). Patients prescribed aspirin did not have a higher risk of recurrent ICH compared with those not prescribed aspirin (22.7 per 1,000 patient-aspirin years vs. 22.4 per 1,000 patient years, p=0.70). Multivariate analysis identified age > 60 years (hazard ratio [HR]: 2.0, 95% confidence interval [CI]: 1.07-3.85, p=0.03) and hypertension (HR: 2.0, 95% CI: 1.06-3.75, p=0.03) as independent predictors for recurrent ICH. In a subgroup analysis including 127 patients with standard indications for aspirin of whom 56 were prescribed aspirin, the incidence of combined vascular events including recurrent ICH, ischaemic stroke, and acute coronary syndrome was statistically lower in patients prescribed aspirin than those not prescribed aspirin (52.4 per 1,000 patient-aspirin years, vs. 112.8 per 1,000 patient- years, p=0.04). In conclusion, we observed in a cohort of Chinese post-ICH patients that aspirin use was not associated with an increased risk for a recurrent ICH. © Schattauer 2012.
ISSN0340-6245
2011 Impact Factor: 5.044
2011 SCImago Journal Rankings: 0.481
DOIhttp://dx.doi.org/10.1160/TH11-06-0439
ISI Accession Number IDWOS:000300748800005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChong, BH
dc.contributor.authorChan, KH
dc.contributor.authorPong, V
dc.contributor.authorLau, KK
dc.contributor.authorChan, YH
dc.contributor.authorZuo, ML
dc.contributor.authorLui, WM
dc.contributor.authorLeung, GKK
dc.contributor.authorLau, CP
dc.contributor.authorTse, HF
dc.contributor.authorPu, JKS
dc.contributor.authorSiu, CW
dc.date.accessioned2012-02-03T06:13:42Z
dc.date.available2012-02-03T06:13:42Z
dc.date.issued2012
dc.description.abstractIntracranial haemorrhage (ICH) accounts for ∼35% of all strokes in Chinese. Anti-platelet agent is often avoided after an index event due to the possibility of recurrent ICH. This single-centered observational study included 440 consecutive Chinese patients with a first spontaneous ICH surviving the first month performed during 1996-2010. The subjects were identified, and their clinical characteristics, anti-platelet therapy after ICH, and outcomes including recurrent ICH, ischaemic stroke, and acute coronary syndrome were checked from hospital records. Of these 440 patients, 56 patients (12.7%) were prescribed aspirin (312 patientaspirin years). After a follow-up of 62.2 ± 1.8 months, 47 patients had recurrent ICH (10.7%, 20.6 per 1,000 patient years). Patients prescribed aspirin did not have a higher risk of recurrent ICH compared with those not prescribed aspirin (22.7 per 1,000 patient-aspirin years vs. 22.4 per 1,000 patient years, p=0.70). Multivariate analysis identified age > 60 years (hazard ratio [HR]: 2.0, 95% confidence interval [CI]: 1.07-3.85, p=0.03) and hypertension (HR: 2.0, 95% CI: 1.06-3.75, p=0.03) as independent predictors for recurrent ICH. In a subgroup analysis including 127 patients with standard indications for aspirin of whom 56 were prescribed aspirin, the incidence of combined vascular events including recurrent ICH, ischaemic stroke, and acute coronary syndrome was statistically lower in patients prescribed aspirin than those not prescribed aspirin (52.4 per 1,000 patient-aspirin years, vs. 112.8 per 1,000 patient- years, p=0.04). In conclusion, we observed in a cohort of Chinese post-ICH patients that aspirin use was not associated with an increased risk for a recurrent ICH. © Schattauer 2012.
dc.description.naturepublished_or_final_version
dc.identifier.citationThrombosis And Haemostasis, 2012, v. 107 n. 2, p. 241-247 [How to Cite?]
DOI: http://dx.doi.org/10.1160/TH11-06-0439
dc.identifier.doihttp://dx.doi.org/10.1160/TH11-06-0439
dc.identifier.epage247
dc.identifier.hkuros198412
dc.identifier.isiWOS:000300748800005
dc.identifier.issn0340-6245
2011 Impact Factor: 5.044
2011 SCImago Journal Rankings: 0.481
dc.identifier.issue2
dc.identifier.pmid22187066
dc.identifier.scopuseid_2-s2.0-84856638385
dc.identifier.spage241
dc.identifier.urihttp://hdl.handle.net/10722/144558
dc.identifier.volume107
dc.languageeng
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
dc.publisher.placeGermany
dc.relation.ispartofThrombosis and Haemostasis
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAge Factors
dc.subject.meshAspirin - administration & dosage - adverse effects
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshIntracranial Hemorrhages - drug therapy - physiopathology - surgery
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPlatelet Aggregation Inhibitors - administration & dosage - adverse effects
dc.subject.meshRecurrence
dc.subject.meshRegistries
dc.subject.meshRisk Factors
dc.subject.meshTreatment Outcome
dc.subjectAntiplatelet agents
dc.subjectRisk factors
dc.subjectStroke/prevention
dc.titleUse of aspirin in Chinese after recovery from primary intracranial haemorrhage
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine