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Article: Reliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope

TitleReliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope
Authors
KeywordsAtomic force microscopy
Elastic modulus
Nanoindentation
Oral cancer cells
Viscoelasticity
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/711005/description#description
Citation
Journal of the Mechanical Behavior of Biomedical Materials, 2012, v. 8, p. 134-142 How to Cite?
AbstractThe elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/144553
ISSN
2015 Impact Factor: 2.876
2015 SCImago Journal Rankings: 1.068
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of the Hong Kong Special Administration Region, PR ChinaSEG-HKU06
Funding Information:

The work done in this article was supported by a grant from the University Grants Committee of the Hong Kong Special Administration Region, PR China (Project No. SEG-HKU06).

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, ZLen_HK
dc.contributor.authorNgan, AHWen_HK
dc.contributor.authorTang, Ben_HK
dc.contributor.authorWang, AXen_HK
dc.date.accessioned2012-02-03T06:13:28Z-
dc.date.available2012-02-03T06:13:28Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of the Mechanical Behavior of Biomedical Materials, 2012, v. 8, p. 134-142en_HK
dc.identifier.issn1751-6161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144553-
dc.description.abstractThe elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/711005/description#descriptionen_HK
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of the Mechanical Behavior of Biomedical Materials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the Mechanical Behavior of Biomedical Materials, 2012, v. 8, p. 134-142. DOI: 10.1016/j.jmbbm.2011.11.010-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAtomic force microscopyen_HK
dc.subjectElastic modulusen_HK
dc.subjectNanoindentationen_HK
dc.subjectOral cancer cellsen_HK
dc.subjectViscoelasticityen_HK
dc.titleReliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscopeen_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hken_HK
dc.identifier.emailTang, B: tangbin@hkucc.hku.hken_HK
dc.identifier.authorityNgan, AHW=rp00225en_HK
dc.identifier.authorityTang, B=rp00081en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.jmbbm.2011.11.010en_HK
dc.identifier.pmid22402160-
dc.identifier.scopuseid_2-s2.0-84862777456en_HK
dc.identifier.hkuros198599en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862777456&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.spage134en_HK
dc.identifier.epage142en_HK
dc.identifier.isiWOS:000302586300012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhou, ZL=23017545300en_HK
dc.identifier.scopusauthoridNgan, AHW=7006827202en_HK
dc.identifier.scopusauthoridTang, B=24554184100en_HK
dc.identifier.scopusauthoridWang, AX=16551242600en_HK

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