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Article: Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma

TitlePrognostic significance of phosphorylated RON in esophageal squamous cell carcinoma
Authors
KeywordsEsophageal squamous cell carcinoma
Median survival after surgery
Overexpression
Phosphorylated RON
Poor prognostic marker
Issue Date2012
PublisherHumana Press, Inc. The Journal's web site is located at http://www.humanapress.com/JournalDetail.pasp?journal=14
Citation
Medical Oncology, 2012, v. 29 n. 3, p. 1699-1706 How to Cite?
AbstractEsophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. RON is a transmembrane receptor overexpressed in various cancers; however, the clinical significance of its phosphorylated form (pRON) is not fully deciphered. This report is the first to investigate the expression and clinical significance of pRON in human ESCC. Quantitative polymerase chain reaction revealed an up-regulation of RON mRNA in 70% (7/10) of ESCC tissues when compared to the adjacent nontumor tissues. An overexpression of pRON protein was found in most of the ESCC cell lines studied (4/5) when compared to two non-neoplastic esophageal epithelial cells using immunoblot. In 64 ESCC tissues, pRON was localized at the cell membrane, cytoplasm and nucleus in 15 (23.4%), 63 (98.4%) and 61 (95.3%) cases using immunohistochemistry. Patients having high expression of cytoplasmic pRON significantly associated with shorter median survival when compared to those with low expression (25.41 months vs. 14.43 months), suggesting cytoplasmic pRON as a potential marker for poor prognosis in ESCC patients. © 2011 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/144513
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.837
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, MKCen_HK
dc.contributor.authorLai, KKYen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorLee, NPen_HK
dc.contributor.authorChung, Yen_HK
dc.contributor.authorCheung, LCen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorTang, JCen_HK
dc.contributor.authorLaw, Sen_HK
dc.date.accessioned2012-02-03T06:11:44Z-
dc.date.available2012-02-03T06:11:44Z-
dc.date.issued2012en_HK
dc.identifier.citationMedical Oncology, 2012, v. 29 n. 3, p. 1699-1706en_HK
dc.identifier.issn1357-0560en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144513-
dc.description.abstractEsophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. RON is a transmembrane receptor overexpressed in various cancers; however, the clinical significance of its phosphorylated form (pRON) is not fully deciphered. This report is the first to investigate the expression and clinical significance of pRON in human ESCC. Quantitative polymerase chain reaction revealed an up-regulation of RON mRNA in 70% (7/10) of ESCC tissues when compared to the adjacent nontumor tissues. An overexpression of pRON protein was found in most of the ESCC cell lines studied (4/5) when compared to two non-neoplastic esophageal epithelial cells using immunoblot. In 64 ESCC tissues, pRON was localized at the cell membrane, cytoplasm and nucleus in 15 (23.4%), 63 (98.4%) and 61 (95.3%) cases using immunohistochemistry. Patients having high expression of cytoplasmic pRON significantly associated with shorter median survival when compared to those with low expression (25.41 months vs. 14.43 months), suggesting cytoplasmic pRON as a potential marker for poor prognosis in ESCC patients. © 2011 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherHumana Press, Inc. The Journal's web site is located at http://www.humanapress.com/JournalDetail.pasp?journal=14en_HK
dc.relation.ispartofMedical Oncologyen_HK
dc.subjectEsophageal squamous cell carcinomaen_HK
dc.subjectMedian survival after surgeryen_HK
dc.subjectOverexpressionen_HK
dc.subjectPhosphorylated RONen_HK
dc.subjectPoor prognostic markeren_HK
dc.titlePrognostic significance of phosphorylated RON in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_HK
dc.identifier.emailTsao, SW: gswtsao@hkucc.hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12032-011-0112-9en_HK
dc.identifier.pmid22086736-
dc.identifier.scopuseid_2-s2.0-84872819521en_HK
dc.identifier.hkuros198369en_US
dc.identifier.hkuros208926-
dc.identifier.volume29en_US
dc.identifier.spage1699en_HK
dc.identifier.epage1706en_HK
dc.identifier.isiWOS:000307964100044-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, MKC=8644138500en_HK
dc.identifier.scopusauthoridLai, KKY=54400333100en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridChung, Y=22833625500en_HK
dc.identifier.scopusauthoridCheung, LC=21740536900en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridTang, JC=14056850300en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.citeulike10079717-

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