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Article: Impact of Right Ventricular Pacing on Three-Dimensional Global Left Ventricular Dyssynchrony in Children and Young Adults With Congenital and Acquired Heart Block Associated With Congenital Heart Disease

TitleImpact of Right Ventricular Pacing on Three-Dimensional Global Left Ventricular Dyssynchrony in Children and Young Adults With Congenital and Acquired Heart Block Associated With Congenital Heart Disease
Authors
Issue Date2009
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2009, v. 104 n. 5, p. 700-706 How to Cite?
AbstractThe aim of this study was to determine the effect of long-term right ventricular pacing on left ventricular (LV) mechanical dyssynchrony in children and young adults with congenital and acquired heart block. Eighteen patients aged 19 ± 7 years with congenital heart block (group I), 9 aged 21 ± 11 years with acquired heart block after congenital heart surgery (group II), and 15 healthy control subjects (group III) were studied. The LV volumes, ejection fractions, and systolic dyssynchrony index (SDI) values, as determined using 3-dimensional echocardiography, were compared among groups. Groups I (6.68 ± 2.44%) and II (9.43 ± 4.44%) had significantly greater SDI values than group III (3.88 ± 0.63%) (p = 0.011 and p <0.001, respectively). The prevalence of LV mechanical dyssynchrony (SDI >5.14%, mean + 2 SDs of controls) in groups I and II was 72% and 67%, respectively. In 27 patients with right ventricular pacing, LV SDI values were correlated negatively with the LV ejection fractions (r = -0.74, p <0.001). The times to minimum regional volume were significantly longer in lateral, posterior, and inferior segments in group I and septal and inferior segments in group II compared to those in group III (p <0.05). Compared to patients without LV dyssynchrony, patients with LV dyssynchrony had lower LV ejection fractions (p <0.001), had shorter RR intervals (p <0.001), and tended to have dual-chamber pacing (p = 0.088) but had similar durations of pacing, QRS durations, and positions of pacing wires (epicardial vs endocardial). In conclusion, permanent right ventricular pacing in childhood has a negative effect on LV systolic function through the induction of mechanical dyssynchrony, the magnitude and pattern of which differ between congenital and acquired heart block. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143974
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHong, WJen_HK
dc.contributor.authorYung, Tcen_HK
dc.contributor.authorLun, Ksen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorCheung, Yfen_HK
dc.date.accessioned2011-12-28T08:15:31Z-
dc.date.available2011-12-28T08:15:31Z-
dc.date.issued2009en_HK
dc.identifier.citationAmerican Journal Of Cardiology, 2009, v. 104 n. 5, p. 700-706en_HK
dc.identifier.issn0002-9149en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143974-
dc.description.abstractThe aim of this study was to determine the effect of long-term right ventricular pacing on left ventricular (LV) mechanical dyssynchrony in children and young adults with congenital and acquired heart block. Eighteen patients aged 19 ± 7 years with congenital heart block (group I), 9 aged 21 ± 11 years with acquired heart block after congenital heart surgery (group II), and 15 healthy control subjects (group III) were studied. The LV volumes, ejection fractions, and systolic dyssynchrony index (SDI) values, as determined using 3-dimensional echocardiography, were compared among groups. Groups I (6.68 ± 2.44%) and II (9.43 ± 4.44%) had significantly greater SDI values than group III (3.88 ± 0.63%) (p = 0.011 and p <0.001, respectively). The prevalence of LV mechanical dyssynchrony (SDI >5.14%, mean + 2 SDs of controls) in groups I and II was 72% and 67%, respectively. In 27 patients with right ventricular pacing, LV SDI values were correlated negatively with the LV ejection fractions (r = -0.74, p <0.001). The times to minimum regional volume were significantly longer in lateral, posterior, and inferior segments in group I and septal and inferior segments in group II compared to those in group III (p <0.05). Compared to patients without LV dyssynchrony, patients with LV dyssynchrony had lower LV ejection fractions (p <0.001), had shorter RR intervals (p <0.001), and tended to have dual-chamber pacing (p = 0.088) but had similar durations of pacing, QRS durations, and positions of pacing wires (epicardial vs endocardial). In conclusion, permanent right ventricular pacing in childhood has a negative effect on LV systolic function through the induction of mechanical dyssynchrony, the magnitude and pattern of which differ between congenital and acquired heart block. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageeng-
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_HK
dc.relation.ispartofAmerican Journal of Cardiologyen_HK
dc.subject.meshCardiac Pacing, Artificial-
dc.subject.meshEchocardiography, Three-Dimensional-
dc.subject.meshHeart Block - congenital - physiopathology - therapy - ultrasonography-
dc.subject.meshHeart Defects, Congenital - physiopathology - ultrasonography-
dc.subject.meshVentricular Dysfunction, Left - therapy - ultrasonography-
dc.titleImpact of Right Ventricular Pacing on Three-Dimensional Global Left Ventricular Dyssynchrony in Children and Young Adults With Congenital and Acquired Heart Block Associated With Congenital Heart Diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, Yf:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, Yf=rp00382en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.amjcard.2009.04.036en_HK
dc.identifier.pmid19699348-
dc.identifier.scopuseid_2-s2.0-68749120767en_HK
dc.identifier.hkuros160064-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68749120767&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue5en_HK
dc.identifier.spage700en_HK
dc.identifier.epage706en_HK
dc.identifier.isiWOS:000269756600016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHong, WJ=14010481700en_HK
dc.identifier.scopusauthoridYung, Tc=9132842300en_HK
dc.identifier.scopusauthoridLun, Ks=8363663600en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridCheung, Yf=7202111067en_HK
dc.identifier.citeulike5240705-

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