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Conference Paper: C-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
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TitleC-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
 
AuthorsOng, KL
Tso, AWK
Leung, RYH
Xu, A
Cherny, SS
Sham, PC
Lam, KSL
Cheung, BMY
 
KeywordsMedical sciences
Cardiovascular diseases
 
Issue Date2010
 
PublisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
 
CitationThe International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/sup049
 
AbstractOBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.
 
DescriptionThis journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong
Poster Session
 
ISSN1520-765X
2013 Impact Factor: 5.640
2013 SCImago Journal Rankings: 0.378
 
DOIhttp://dx.doi.org/10.1093/eurheartj/sup049
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorXu, A
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2011-12-16T08:09:22Z
 
dc.date.available2011-12-16T08:09:22Z
 
dc.date.issued2010
 
dc.description.abstractOBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionThis journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong
 
dc.descriptionPoster Session
 
dc.description.otherThe International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022
 
dc.identifier.citationThe International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/sup049
 
dc.identifier.doihttp://dx.doi.org/10.1093/eurheartj/sup049
 
dc.identifier.epageS21
 
dc.identifier.hkuros174608
 
dc.identifier.issn1520-765X
2013 Impact Factor: 5.640
2013 SCImago Journal Rankings: 0.378
 
dc.identifier.issuesuppl. A
 
dc.identifier.spageS21
 
dc.identifier.urihttp://hdl.handle.net/10722/143675
 
dc.identifier.volume12
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Heart Journal Supplements
 
dc.subjectMedical sciences
 
dc.subjectCardiovascular diseases
 
dc.titleC-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
 
dc.typeConference_Paper
 
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<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Leung, RYH</contributor.author>
<contributor.author>Xu, A</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
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<description>Poster Session</description>
<description.abstract>OBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000&#8211;2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005&#8211;2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.</description.abstract>
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