Conference Paper: C-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort

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Title	C-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
Authors	Ong, KL Tso, AWK Leung, RYH Xu, A Cherny, SS Sham, PC Lam, KSL Cheung, BMY
Keywords	Medical sciences Cardiovascular diseases
Issue Date	2010
Publisher	Oxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
Citation	The International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022 [How to Cite?] DOI: http://dx.doi.org/10.1093/eurheartj/sup049
Abstract	OBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.
Description	This journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong Poster Session
ISSN	1520-765X 2011 Impact Factor: 2.681 2011 SCImago Journal Rankings: 0.081
DOI	http://dx.doi.org/10.1093/eurheartj/sup049

DC Field	Value
dc.contributor.author	Ong, KL
dc.contributor.author	Tso, AWK
dc.contributor.author	Leung, RYH
dc.contributor.author	Xu, A
dc.contributor.author	Cherny, SS
dc.contributor.author	Sham, PC
dc.contributor.author	Lam, KSL
dc.contributor.author	Cheung, BMY
dc.date.accessioned	2011-12-16T08:09:22Z
dc.date.available	2011-12-16T08:09:22Z
dc.date.issued	2010
dc.description.abstract	OBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.
dc.description.nature	link_to_OA_fulltext
dc.description	This journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong
dc.description	Poster Session
dc.description.other	The International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022
dc.identifier.citation	The International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022 [How to Cite?] DOI: http://dx.doi.org/10.1093/eurheartj/sup049
dc.identifier.doi	http://dx.doi.org/10.1093/eurheartj/sup049
dc.identifier.epage	S21
dc.identifier.hkuros	174608
dc.identifier.issn	1520-765X 2011 Impact Factor: 2.681 2011 SCImago Journal Rankings: 0.081
dc.identifier.issue	suppl. A
dc.identifier.spage	S21
dc.identifier.uri	http://hdl.handle.net/10722/143675
dc.identifier.volume	12
dc.language	eng
dc.publisher	Oxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
dc.publisher.place	United Kingdom
dc.relation.ispartof	European Heart Journal Supplements
dc.subject	Medical sciences
dc.subject	Cardiovascular diseases
dc.title	C-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
dc.type	Conference_Paper

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