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Conference Paper: C-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort

TitleC-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohort
Authors
KeywordsMedical sciences
Cardiovascular diseases
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
Citation
The International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022 How to Cite?
Abstract
OBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.
DescriptionThis journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong
Persistent Identifierhttp://hdl.handle.net/10722/143675
ISSN
2013 Impact Factor: 5.640
2013 SCImago Journal Rankings: 0.378

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_US
dc.contributor.authorTso, AWKen_US
dc.contributor.authorLeung, RYHen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorCherny, SSen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorCheung, BMYen_US
dc.date.accessioned2011-12-16T08:09:22Z-
dc.date.available2011-12-16T08:09:22Z-
dc.date.issued2010en_US
dc.identifier.citationThe International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022en_US
dc.identifier.issn1520-765Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/143675-
dc.descriptionThis journal supplement with title: Abstracts from the International Congress of Cardiology, 26-28 February 2010, Hong Kong-
dc.descriptionPoster Session-
dc.description.abstractOBJECTIVE: Inflammation contributes to the development and progression of hypertension. However, whether C-reactive protein plays a causal role in hypertension is questionable. We studied single-nucleotide polymorphisms (SNPs) in the C-reactive protein gene as a determinant of its plasma levels and the propensity to develop hypertension in a population-based prospective cohort of Hong Kong Chinese. METHODS: The genotypes of nine SNPs and plasma C-reactive protein were determined in 1938 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000–2004. Among 1388 subjects normotensive in CRISPS-2, 1124 subjects had been followed up in CRISPS-3 in 2005–2008, in which 237 subjects developed hypertension. RESULTS: Subjects with prevalent or incident hypertension had significantly higher plasma C-reactive protein level (P , 0.001). Plasma C-reactive protein correlated positively with both systolic and diastolic blood pressures (P , 0.001). Six of the nine SNPs were significantly associated with plasma C-reactive protein level (P , 0.001). The SNPs rs3093068 and rs1800947 were independently associated with higher and lower C-reactive protein levels, respectively, in stepwise linear regression analysis (P , 0.001). Among subjects normotensive in CRISPS-2, plasma C-reactive protein was an independent predictor of developing hypertension in CRISPS-3 (P , 0.005). However, none of the SNPs was significantly associated with blood pressure, prevalent or incident hypertension. CONCLUSION: Genetic variants in the C-reactive protein gene are associated with plasma C-reactive protein level only, but not with hypertension. This suggests that C-reactive protein may not play a direct casual role in the development of hypertension although its plasma level is elevated before the onset of hypertension development.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.orgen_US
dc.relation.ispartofEuropean Heart Journal Supplementsen_US
dc.subjectMedical sciences-
dc.subjectCardiovascular diseases-
dc.titleC-reactive protein as a predictor of hypertension in the Hong Kong cardiovascular risk prevalence study (CRISPS) cohorten_US
dc.typeConference_Paper-
dc.identifier.emailOng, KL: okl2000@hku.hken_US
dc.identifier.emailTso, AWK: awktso@hku.hk-
dc.identifier.emailLeung, RYH: yhleung@hkucc.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailCherny, SS: cherny@hku.hk-
dc.identifier.emailSham, PC: pcsham@.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hku.hk-
dc.identifier.authorityTso, AWK=rp00535en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/eurheartj/sup049-
dc.identifier.hkuros174608-
dc.identifier.volume12en_US
dc.identifier.issuesuppl. A-
dc.identifier.spageS21en_US
dc.identifier.epageS21en_US
dc.publisher.placeUnited Kingdom-
dc.description.otherThe International Congress of Cardiology, Hong Kong, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 suppl. A, p. S21, abstract P022-

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