Article: Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
| Title | Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome | ||||
|---|---|---|---|---|---|
| Authors | Xiao, L1 Ng, TB4 Feng, YB2 Yao, T2 Wong, JH2 Yao, RM2 Li, L2 Mo, FZ2 Xiao, Y2 Shaw, PC4 Li, ZM3 Sze, SCW2 Zhang, KY2 | ||||
| Keywords | Aquaporin-5 (AQP-5) Dendrobium candidum Herb medicine Labial gland Mechanisms Sjögren's syndrome (SS) | ||||
| Issue Date | 2011 | ||||
| Publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed | ||||
| Citation | Phytomedicine, 2011, v. 18 n. 2-3, p. 194-198 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.phymed.2010.05.002 | ||||
| Abstract | This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH. | ||||
| ISSN | 0944-7113 2011 Impact Factor: 3.268 2011 SCImago Journal Rankings: 0.133 | ||||
| DOI | http://dx.doi.org/10.1016/j.phymed.2010.05.002 | ||||
| ISI Accession Number ID | WOS:000287767800016
Funding Information: This work was supported by grants (Project codes 10208016 and 10400168) from the University of Hong Kong. We appreciate the help of Prof. WANG Zhengtao, Department of Pharmacognosy, China Pharmaceutical University in providing samples and authentication of plant resources by using morphological and histological methods. | ||||
| References | References in Scopus |
| dc.contributor.author | Xiao, L | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Ng, TB | ||||
| dc.contributor.author | Feng, YB | ||||
| dc.contributor.author | Yao, T | ||||
| dc.contributor.author | Wong, JH | ||||
| dc.contributor.author | Yao, RM | ||||
| dc.contributor.author | Li, L | ||||
| dc.contributor.author | Mo, FZ | ||||
| dc.contributor.author | Xiao, Y | ||||
| dc.contributor.author | Shaw, PC | ||||
| dc.contributor.author | Li, ZM | ||||
| dc.contributor.author | Sze, SCW | ||||
| dc.contributor.author | Zhang, KY | ||||
| dc.date.accessioned | 2011-10-28T03:01:35Z | ||||
| dc.date.available | 2011-10-28T03:01:35Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Phytomedicine, 2011, v. 18 n. 2-3, p. 194-198 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.phymed.2010.05.002 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.phymed.2010.05.002 | ||||
| dc.identifier.epage | 198 | ||||
| dc.identifier.hkuros | 197182 | ||||
| dc.identifier.isi | WOS:000287767800016
Funding Information: This work was supported by grants (Project codes 10208016 and 10400168) from the University of Hong Kong. We appreciate the help of Prof. WANG Zhengtao, Department of Pharmacognosy, China Pharmaceutical University in providing samples and authentication of plant resources by using morphological and histological methods. | ||||
| dc.identifier.issn | 0944-7113 2011 Impact Factor: 3.268 2011 SCImago Journal Rankings: 0.133 | ||||
| dc.identifier.issue | 2-3 | ||||
| dc.identifier.pmid | 20655712 | ||||
| dc.identifier.scopus | eid_2-s2.0-78651273527 | ||||
| dc.identifier.spage | 194 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/142996 | ||||
| dc.identifier.volume | 18 | ||||
| dc.language | eng | ||||
| dc.publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed | ||||
| dc.publisher.place | Germany | ||||
| dc.relation.ispartof | Phytomedicine | ||||
| dc.relation.references | References in Scopus | ||||
| dc.subject.mesh | Aquaporin 5 - metabolism | ||||
| dc.subject.mesh | Dendrobium | ||||
| dc.subject.mesh | Plant Extracts - pharmacology - therapeutic use | ||||
| dc.subject.mesh | Saliva - metabolism - secretion | ||||
| dc.subject.mesh | Salivary Glands - drug effects - metabolism | ||||
| dc.subject | Aquaporin-5 (AQP-5) | ||||
| dc.subject | Dendrobium candidum | ||||
| dc.subject | Herb medicine | ||||
| dc.subject | Labial gland | ||||
| dc.subject | Mechanisms | ||||
| dc.subject | Sjögren's syndrome (SS) | ||||
| dc.title | Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome | ||||
| dc.type | Article |
Author Affiliations
- Fuling Central Hospital
- The University of Hong Kong
- Dalian Hospital
- Chinese University of Hong Kong