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Article: Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
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TitleDendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
 
AuthorsXiao, L1
Ng, TB4
Feng, YB2
Yao, T2
Wong, JH2
Yao, RM2
Li, L2
Mo, FZ2
Xiao, Y2
Shaw, PC4
Li, ZM3
Sze, SCW2
Zhang, KY2
 
KeywordsAquaporin-5 (AQP-5)
Dendrobium candidum
Herb medicine
Labial gland
Mechanisms
Sjögren's syndrome (SS)
 
Issue Date2011
 
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
 
CitationPhytomedicine, 2011, v. 18 n. 2-3, p. 194-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.phymed.2010.05.002
 
AbstractThis study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH.
 
ISSN0944-7113
2012 Impact Factor: 2.972
2012 SCImago Journal Rankings: 0.952
 
DOIhttp://dx.doi.org/10.1016/j.phymed.2010.05.002
 
ISI Accession Number IDWOS:000287767800016
Funding AgencyGrant Number
University of Hong Kong10208016
10400168
Funding Information:

This work was supported by grants (Project codes 10208016 and 10400168) from the University of Hong Kong. We appreciate the help of Prof. WANG Zhengtao, Department of Pharmacognosy, China Pharmaceutical University in providing samples and authentication of plant resources by using morphological and histological methods.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXiao, L
 
dc.contributor.authorNg, TB
 
dc.contributor.authorFeng, YB
 
dc.contributor.authorYao, T
 
dc.contributor.authorWong, JH
 
dc.contributor.authorYao, RM
 
dc.contributor.authorLi, L
 
dc.contributor.authorMo, FZ
 
dc.contributor.authorXiao, Y
 
dc.contributor.authorShaw, PC
 
dc.contributor.authorLi, ZM
 
dc.contributor.authorSze, SCW
 
dc.contributor.authorZhang, KY
 
dc.date.accessioned2011-10-28T03:01:35Z
 
dc.date.available2011-10-28T03:01:35Z
 
dc.date.issued2011
 
dc.description.abstractThis study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationPhytomedicine, 2011, v. 18 n. 2-3, p. 194-198 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.phymed.2010.05.002
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.phymed.2010.05.002
 
dc.identifier.epage198
 
dc.identifier.hkuros197182
 
dc.identifier.isiWOS:000287767800016
Funding AgencyGrant Number
University of Hong Kong10208016
10400168
Funding Information:

This work was supported by grants (Project codes 10208016 and 10400168) from the University of Hong Kong. We appreciate the help of Prof. WANG Zhengtao, Department of Pharmacognosy, China Pharmaceutical University in providing samples and authentication of plant resources by using morphological and histological methods.

 
dc.identifier.issn0944-7113
2012 Impact Factor: 2.972
2012 SCImago Journal Rankings: 0.952
 
dc.identifier.issue2-3
 
dc.identifier.pmid20655712
 
dc.identifier.scopuseid_2-s2.0-78651273527
 
dc.identifier.spage194
 
dc.identifier.urihttp://hdl.handle.net/10722/142996
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
 
dc.publisher.placeGermany
 
dc.relation.ispartofPhytomedicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAquaporin 5 - metabolism
 
dc.subject.meshDendrobium
 
dc.subject.meshPlant Extracts - pharmacology - therapeutic use
 
dc.subject.meshSaliva - metabolism - secretion
 
dc.subject.meshSalivary Glands - drug effects - metabolism
 
dc.subjectAquaporin-5 (AQP-5)
 
dc.subjectDendrobium candidum
 
dc.subjectHerb medicine
 
dc.subjectLabial gland
 
dc.subjectMechanisms
 
dc.subjectSjögren's syndrome (SS)
 
dc.titleDendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
 
dc.typeArticle
 
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Author Affiliations
  1. Fuling Central Hospital
  2. The University of Hong Kong
  3. Dalian Hospital
  4. Chinese University of Hong Kong