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Article: Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome

TitleDendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
Authors
KeywordsAquaporin-5 (AQP-5)
Dendrobium candidum
Herb medicine
Labial gland
Mechanisms
Sjögren's syndrome (SS)
Issue Date2011
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2011, v. 18 n. 2-3, p. 194-198 How to Cite?
AbstractThis study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/142996
ISSN
2014 Impact Factor: 3.126
2013 SCImago Journal Rankings: 1.023
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10208016
10400168
Funding Information:

This work was supported by grants (Project codes 10208016 and 10400168) from the University of Hong Kong. We appreciate the help of Prof. WANG Zhengtao, Department of Pharmacognosy, China Pharmaceutical University in providing samples and authentication of plant resources by using morphological and histological methods.

References

 

DC FieldValueLanguage
dc.contributor.authorXiao, Len_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorFeng, YBen_HK
dc.contributor.authorYao, Ten_HK
dc.contributor.authorWong, JHen_HK
dc.contributor.authorYao, RMen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorMo, FZen_HK
dc.contributor.authorXiao, Yen_HK
dc.contributor.authorShaw, PCen_HK
dc.contributor.authorLi, ZMen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorZhang, KYen_HK
dc.date.accessioned2011-10-28T03:01:35Z-
dc.date.available2011-10-28T03:01:35Z-
dc.date.issued2011en_HK
dc.identifier.citationPhytomedicine, 2011, v. 18 n. 2-3, p. 194-198en_HK
dc.identifier.issn0944-7113en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142996-
dc.description.abstractThis study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms. © 2010 Elsevier GmbH.en_HK
dc.languageengen_US
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_HK
dc.relation.ispartofPhytomedicineen_HK
dc.subjectAquaporin-5 (AQP-5)en_HK
dc.subjectDendrobium candidumen_HK
dc.subjectHerb medicineen_HK
dc.subjectLabial glanden_HK
dc.subjectMechanismsen_HK
dc.subjectSjögren's syndrome (SS)en_HK
dc.subject.meshAquaporin 5 - metabolism-
dc.subject.meshDendrobium-
dc.subject.meshPlant Extracts - pharmacology - therapeutic use-
dc.subject.meshSaliva - metabolism - secretion-
dc.subject.meshSalivary Glands - drug effects - metabolism-
dc.titleDendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndromeen_HK
dc.typeArticleen_HK
dc.identifier.emailFeng, YB: yfeng@hku.hken_HK
dc.identifier.emailYao, RM: yoyo@hku.hken_HK
dc.identifier.emailLi, L: llie@hkucc.hku.hken_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailZhang, KY: ybzhang@hku.hken_HK
dc.identifier.authorityFeng, YB=rp00466en_HK
dc.identifier.authorityYao, RM=rp00464en_HK
dc.identifier.authorityLi, L=rp01353en_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityZhang, KY=rp01410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.phymed.2010.05.002en_HK
dc.identifier.pmid20655712en_HK
dc.identifier.scopuseid_2-s2.0-78651273527en_HK
dc.identifier.hkuros197182en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651273527&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage194en_HK
dc.identifier.epage198en_HK
dc.identifier.isiWOS:000287767800016-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridXiao, L=47961584500en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.scopusauthoridFeng, YB=24467969600en_HK
dc.identifier.scopusauthoridYao, T=47961587000en_HK
dc.identifier.scopusauthoridWong, JH=34874358200en_HK
dc.identifier.scopusauthoridYao, RM=22837434700en_HK
dc.identifier.scopusauthoridLi, L=47961141000en_HK
dc.identifier.scopusauthoridMo, FZ=47961320600en_HK
dc.identifier.scopusauthoridXiao, Y=47961510800en_HK
dc.identifier.scopusauthoridShaw, PC=35599523600en_HK
dc.identifier.scopusauthoridLi, ZM=47961201900en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridZhang, KY=23483121900en_HK

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