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Conference Paper: Microfluidic chip-capillary electrophoresis with adjustable on-chip sample dilution for profiling of urinary markers

TitleMicrofluidic chip-capillary electrophoresis with adjustable on-chip sample dilution for profiling of urinary markers
Authors
KeywordsFerrofluid valve
Microchip CE
Metabolite disorder
Micromixer
Issue Date2010
Citation
The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 3-7 October 2010. In Conference Proceedings, 2010, p. 1481-1483 How to Cite?
AbstractThe paper reports the development of a microfluidic chip-capillary electrophoresis device using UV/Vis detection for profiling of urinary markers with adjustable on-chip sample dilution. A PMMA polymer microfluidic chip-CE device with on-chip ferrofluid valve control for adjustable sample dilution is developed for profiling of urinary markers related to metabolism disorders for clinical diagnosis. On-chip sample dilution up to a 100 folds can be achieved prior to separation in a running buffer containing 3mM 1,3,5-benzenetricarboxylic acid (BTA), 1.5 mM tetraethylenepentamine (TEPA) and 15mM tris(hydroxyl) aminomethane (Tris buffer) solution with pH adjusted to 8.4 by lithium hydroxide.
Persistent Identifierhttp://hdl.handle.net/10722/142691
ISBN

 

DC FieldValueLanguage
dc.contributor.authorGuo, Wen_US
dc.contributor.authorFung, YSen_US
dc.date.accessioned2011-10-28T02:54:22Z-
dc.date.available2011-10-28T02:54:22Z-
dc.date.issued2010en_US
dc.identifier.citationThe 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 3-7 October 2010. In Conference Proceedings, 2010, p. 1481-1483en_US
dc.identifier.isbn978-0-9798064-3-8-
dc.identifier.urihttp://hdl.handle.net/10722/142691-
dc.description.abstractThe paper reports the development of a microfluidic chip-capillary electrophoresis device using UV/Vis detection for profiling of urinary markers with adjustable on-chip sample dilution. A PMMA polymer microfluidic chip-CE device with on-chip ferrofluid valve control for adjustable sample dilution is developed for profiling of urinary markers related to metabolism disorders for clinical diagnosis. On-chip sample dilution up to a 100 folds can be achieved prior to separation in a running buffer containing 3mM 1,3,5-benzenetricarboxylic acid (BTA), 1.5 mM tetraethylenepentamine (TEPA) and 15mM tris(hydroxyl) aminomethane (Tris buffer) solution with pH adjusted to 8.4 by lithium hydroxide.-
dc.languageengen_US
dc.relation.ispartofProceedings of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFerrofluid valve-
dc.subjectMicrochip CE-
dc.subjectMetabolite disorder-
dc.subjectMicromixer-
dc.titleMicrofluidic chip-capillary electrophoresis with adjustable on-chip sample dilution for profiling of urinary markersen_US
dc.typeConference_Paperen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=978-0-9798064-3-8&volume=&spage=1481&epage=1483&date=2010&atitle=Microfluidic+chip-capillary+electrophoresis+with+adjustable+on-chip+sample+dilution+for+profiling+of+urinary+markers-
dc.identifier.emailFung, YS: ysfung@hku.hken_US
dc.identifier.authorityFung, YS=rp00697en_US
dc.description.naturepostprint-
dc.identifier.hkuros196866en_US
dc.identifier.spage1481en_US
dc.identifier.epage1483en_US
dc.description.otherThe 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 3-7 October 2010. In Conference Proceedings, 2010, p. 1481-1483-

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