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Article: Recent advances in IgA nephropathy - The glomerulopodocytic-tubular communication

TitleRecent advances in IgA nephropathy - The glomerulopodocytic-tubular communication
Authors
Lai, KNTang, SCWLeung, JCK
Issue Date2011
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/ADORL
Citation
Advances In Oto-Rhino-Laryngology, 2011, v. 72, p. 40-44 How to Cite?
DOI: http://dx.doi.org/10.1159/000324593
AbstractIgA nephropathy (IgAN) is characterized by mesangial deposition of pathogenic polymeric IgA1 with rare deposits in the tubular epithelial cells (TEC). Recently, a novel mechanism involving a glomerulopodocytictubular cross-talk in the development of tubulointerstitial damage in IgAN has been revealed. Podocytes are positioned strategically along the glomerulotubular axis and plays an important role in mediating the glomerulotubular cross-talk. In IgAN, podocyte markers are reduced in the glomeruli. In vitro study implicates humoral factors (predominantly tumor necrosis factor-α and transforming growth factor-β) released from mesangial cells alter the glomerular permeability in the event of proteinuria and tubulointerstitial injury in IgAN. These mediators released from mesangial cells after IgA deposition further activate TEC leading to subsequent inflammatory changes in the renal tubulointerstitium. Copyright © 2011 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/142392
ISSN
0065-3071
2020 SCImago Journal Rankings: 0.585
ISI Accession Number ID
WOS:000302382800008
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLeung, JCKen_HK
dc.date.accessioned2011-10-28T02:44:57Z-
dc.date.available2011-10-28T02:44:57Z-
dc.date.issued2011en_HK
dc.identifier.citationAdvances In Oto-Rhino-Laryngology, 2011, v. 72, p. 40-44en_HK
dc.identifier.issn0065-3071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142392-
dc.description.abstractIgA nephropathy (IgAN) is characterized by mesangial deposition of pathogenic polymeric IgA1 with rare deposits in the tubular epithelial cells (TEC). Recently, a novel mechanism involving a glomerulopodocytictubular cross-talk in the development of tubulointerstitial damage in IgAN has been revealed. Podocytes are positioned strategically along the glomerulotubular axis and plays an important role in mediating the glomerulotubular cross-talk. In IgAN, podocyte markers are reduced in the glomeruli. In vitro study implicates humoral factors (predominantly tumor necrosis factor-α and transforming growth factor-β) released from mesangial cells alter the glomerular permeability in the event of proteinuria and tubulointerstitial injury in IgAN. These mediators released from mesangial cells after IgA deposition further activate TEC leading to subsequent inflammatory changes in the renal tubulointerstitium. Copyright © 2011 S. Karger AG, Basel.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/ADORLen_HK
dc.relation.ispartofAdvances in Oto-Rhino-Laryngologyen_HK
dc.rightsAdvances in Oto-Rhino-Laryngology. Copyright © S Karger AG.en_US
dc.subject.meshCell Communication-
dc.subject.meshCell Proliferation-
dc.subject.meshGlomerular Mesangium - pathology-
dc.subject.meshGlomerulonephritis, IGA - pathology-
dc.subject.meshKidney Tubules, Proximal - pathology-
dc.titleRecent advances in IgA nephropathy - The glomerulopodocytic-tubular communicationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0065-3071&volume=72&spage=40&epage=44&date=2011&atitle=Recent+advances+in+IgA+nephropathy+-+the+glomerulopodocytic-tubular+communicationen_US
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000324593en_HK
dc.identifier.pmid21865686-
dc.identifier.scopuseid_2-s2.0-80052486924en_HK
dc.identifier.hkuros196743en_US
dc.identifier.hkuros203716-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052486924&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.spage40en_HK
dc.identifier.epage44en_HK
dc.identifier.isiWOS:000302382800008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridTang, SCW=7403437082en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.issnl0065-3071-

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