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Book Chapter: Discriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetry

TitleDiscriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetry
Authors
Issue Date2011
PublisherIOS Press
Citation
Discriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetry. In Ashford, JW ... (Eds.)(et al), Handbook of imaging the alzheimer brain, p. 729-737. Amsterdam, the Netherlands: IOS Press, 2011 How to Cite?
AbstractHippocampal atrophy on Magnetic Resonance Imaging (MRI) has been increasingly used as a supportive feature for the diagnosis of Alzheimer's patients. We attempt to compare voxel-based morphometry (VBM) with DARTEL and standard registration versus manual hippocampal volumetry in discriminating Alzheimer's disease (AD) patients from cognitively normal older adults. Participants were 20 cognitively normal elderly subjects and 19 AD patients who met the criteria of probable AD according to NINCDS-ADRDA. High resolution T1-weighted (T1W) 3D volumetric Fast Field Echo sequence was obtained using 3.0-Tesla scanner. Bilateral manual hippocampal volumetry (ANALYZE 7.0 software) and VBM hippocampal region-of-interests (using hippocampal masks MARINA) were generated with DARTEL and standard registration (Statistical Parametric Mapping SPM5 software). Normalization with total intracranial volumes was employed for both methods. All normalized hippocampal measurements showed significant reduction (20–30%; p < 0.001) in AD compared to controls. Logistic regression analysis also showed significant effects (odds ratios ranged from 88.2% to 94.0%) of all normalized measurements in predicting AD incidence after adjusting for age, gender, and education. The overall prediction accuracies of manual RH and LH volumes, standard RH-ROI and LH-ROI VBM, DARTEL RH-ROI and LH-ROI VBM were 87.2%, 84.6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults.
Persistent Identifierhttp://hdl.handle.net/10722/141390
ISBN

 

DC FieldValueLanguage
dc.contributor.authorMak, HKFen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorYau, KKWen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorChan, Qen_US
dc.contributor.authorChu, LWen_US
dc.date.accessioned2011-09-23T06:33:23Z-
dc.date.available2011-09-23T06:33:23Z-
dc.date.issued2011en_US
dc.identifier.citationDiscriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetry. In Ashford, JW ... (Eds.)(et al), Handbook of imaging the alzheimer brain, p. 729-737. Amsterdam, the Netherlands: IOS Press, 2011en_US
dc.identifier.isbn9781607507925-
dc.identifier.urihttp://hdl.handle.net/10722/141390-
dc.description.abstractHippocampal atrophy on Magnetic Resonance Imaging (MRI) has been increasingly used as a supportive feature for the diagnosis of Alzheimer's patients. We attempt to compare voxel-based morphometry (VBM) with DARTEL and standard registration versus manual hippocampal volumetry in discriminating Alzheimer's disease (AD) patients from cognitively normal older adults. Participants were 20 cognitively normal elderly subjects and 19 AD patients who met the criteria of probable AD according to NINCDS-ADRDA. High resolution T1-weighted (T1W) 3D volumetric Fast Field Echo sequence was obtained using 3.0-Tesla scanner. Bilateral manual hippocampal volumetry (ANALYZE 7.0 software) and VBM hippocampal region-of-interests (using hippocampal masks MARINA) were generated with DARTEL and standard registration (Statistical Parametric Mapping SPM5 software). Normalization with total intracranial volumes was employed for both methods. All normalized hippocampal measurements showed significant reduction (20–30%; p < 0.001) in AD compared to controls. Logistic regression analysis also showed significant effects (odds ratios ranged from 88.2% to 94.0%) of all normalized measurements in predicting AD incidence after adjusting for age, gender, and education. The overall prediction accuracies of manual RH and LH volumes, standard RH-ROI and LH-ROI VBM, DARTEL RH-ROI and LH-ROI VBM were 87.2%, 84.6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults.-
dc.languageengen_US
dc.publisherIOS Press-
dc.relation.ispartofHandbook of imaging the alzheimer brainen_US
dc.titleDiscriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes- voxel based morphometry with DARTEL and standard registration versus manual volumetryen_US
dc.typeBook_Chapteren_US
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_US
dc.identifier.emailChu, LW: lwchu@hkucc.hku.hken_US
dc.identifier.authorityMak, HKF=rp00533en_US
dc.identifier.doi10.3233/978-1-60750-793-2-729-
dc.identifier.hkuros192690en_US
dc.identifier.spage729-
dc.identifier.epage737-
dc.publisher.placeAmsterdam, the Netherlands-

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