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Conference Paper: Postnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map

TitlePostnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial map
Authors
KeywordsFos
inferior olive
thalamus
Issue Date2010
PublisherSociety for Neuroscience.
Citation
The 40th Annual Meeting of the Society for Neuroscience (SfN 2010), San Diego, California, USA, 13-17 November 2010 How to Cite?
AbstractN-methyl-D-aspartate (NMDA) receptor and γ-aminobutyric acid (GABA) receptor play important roles in regulating the maturation of different sensory systems, including the visual, auditory and somatosensory systems. With the use of Fos protein expression as a neuronal marker for postsynaptic activation after sinusoidal horizontal rotation, we have revealed the occurrence of a spatial map in the inferior olive (IO) and thalamus, the descending and ascending relay stations of the vestibular circuitry respectively. To ascertain the contribution of excitatory and inhibitory inputs on the formation of spatial map in the central vestibular system, Elvax slice loaded with NMDA receptor antagonist MK801 or GABAA receptor antagonist bicuculline methoiodine was implanted over the bilateral vestibular nucleus (VN) of neonatal rats. The rats were allowed to recover until adulthood. We found that adult rats pretreated at P1 with MK801 or bicuculline could stay on rotating rod for shorter times than the controls. Comparable motor deficits were observed in animals either with selective destruction of IO cells by 3-acetylpyridine treatment or with electrolytic lesion of thalamic subnuclei that expressed horizontal rotation triggered Fos-positive neurons. Derangement of spatial map in IO and thalamus was also observed in both MK801-treated and bicuculline-treated adult rats, suggesting that postnatal NMDA and GABA transmission within VN is critical for developmental establishment of neural network for spatial map that encodes rotational motion in mature animals.
DescriptionPoster Session 843: Development of Auditory and Vestibular Systems
Program no. 843.1 & Poster no. D8
Fulltext of the abstract in: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=2554&sKey=eb3b85c4-1e5a-412a-b4f5-1153a8807a6a&cKey=17d8423b-6ba2-48fc-91c3-0b36cfde14e6&mKey=e5d5c83f-ce2d-4d71-9dd6-fc7231e090fb
Persistent Identifierhttp://hdl.handle.net/10722/140523

 

DC FieldValueLanguage
dc.contributor.authorNg, KPen_US
dc.contributor.authorLai, SKen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorShum, DKYen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2011-09-23T06:13:55Z-
dc.date.available2011-09-23T06:13:55Z-
dc.date.issued2010en_US
dc.identifier.citationThe 40th Annual Meeting of the Society for Neuroscience (SfN 2010), San Diego, California, USA, 13-17 November 2010en_US
dc.identifier.urihttp://hdl.handle.net/10722/140523-
dc.descriptionPoster Session 843: Development of Auditory and Vestibular Systems-
dc.descriptionProgram no. 843.1 & Poster no. D8-
dc.descriptionFulltext of the abstract in: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=2554&sKey=eb3b85c4-1e5a-412a-b4f5-1153a8807a6a&cKey=17d8423b-6ba2-48fc-91c3-0b36cfde14e6&mKey=e5d5c83f-ce2d-4d71-9dd6-fc7231e090fb-
dc.description.abstractN-methyl-D-aspartate (NMDA) receptor and γ-aminobutyric acid (GABA) receptor play important roles in regulating the maturation of different sensory systems, including the visual, auditory and somatosensory systems. With the use of Fos protein expression as a neuronal marker for postsynaptic activation after sinusoidal horizontal rotation, we have revealed the occurrence of a spatial map in the inferior olive (IO) and thalamus, the descending and ascending relay stations of the vestibular circuitry respectively. To ascertain the contribution of excitatory and inhibitory inputs on the formation of spatial map in the central vestibular system, Elvax slice loaded with NMDA receptor antagonist MK801 or GABAA receptor antagonist bicuculline methoiodine was implanted over the bilateral vestibular nucleus (VN) of neonatal rats. The rats were allowed to recover until adulthood. We found that adult rats pretreated at P1 with MK801 or bicuculline could stay on rotating rod for shorter times than the controls. Comparable motor deficits were observed in animals either with selective destruction of IO cells by 3-acetylpyridine treatment or with electrolytic lesion of thalamic subnuclei that expressed horizontal rotation triggered Fos-positive neurons. Derangement of spatial map in IO and thalamus was also observed in both MK801-treated and bicuculline-treated adult rats, suggesting that postnatal NMDA and GABA transmission within VN is critical for developmental establishment of neural network for spatial map that encodes rotational motion in mature animals.-
dc.languageengen_US
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofNeuroscience 2010-
dc.rightsNeuroscience 2010. Copyright © Society for Neuroscience.-
dc.subjectFos-
dc.subjectinferior olive-
dc.subjectthalamus-
dc.titlePostnatal glutamatergic and GABAergic transmission within the vestibular nucleus is critical for the maturation of canal-related spatial mapen_US
dc.typeConference_Paperen_US
dc.identifier.emailNg, KP: kapakng@hku.hken_US
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hken_US
dc.identifier.authorityLai, CH=rp00396en_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.identifier.hkuros195388en_US
dc.publisher.placeUnited States-

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