Conference Paper: Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency

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Title	Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency
Authors	Yuen, MM Chow, WS Cheng, C Pun, TC Law, LSC Tso, AWK Xu, A Lam, KSL
Issue Date	2011
Publisher	American Diabetes Association.
Citation	The 71st American Diabetes Association Scientific Sessions, San Diego, CA., 24-28 June 2011. [How to Cite?]
Abstract	Pigment epithelium-derived factor (PEDF) is implicated in murine insulin resistance and metabolic dysfunctions. Women have lower serum PEDF levels and 17β-estradiol inhibits the transcription of PEDF in human ovarian epithelial cells. To investigate whether estradiol regulates PEDF in vivo, we studied the changes in PEDF levels in 21 pre-menopausal women (age = 49.6 ± 3.5 years) following bilateral oophorectomy for benign gynaecological conditions. Body mass index (BMI), waist circumference (WC), percentage body fat, and plasma PEDF (ng/ml) and estradiol (pmol/l) levels were measured before and after oophorectomy. The changes (Δ) in PEDF, estradiol, homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI) were analyzed with repeated measure ANOVA. The mean duration between pre- and post-operative assessment was 4.0±0.7 months. BMI was marginally reduced in the post-operative period (25.2 ± 4.0 kg/m2 pre-op vs. 24.8 ± 4.3 kg/m2 post-op; p = 0.048). There were no significant changes in WC or percentage body fat The marked post-operative reduction in plasma estradiol levels (225 [109-418] pmol/l pre-op vs. 32 [19-50] pmol/l post-op; p < 0.001) was associated with increases in plasma PEDF levels (7.7 ± 1.6 ng/ml pre-op vs. 8.8 ± 1.5 ng/ml post-op; p = 0.001). An inverse relationship was found between Δestradiol and ΔPEDF (r = -0.497; p = 0.022). Insulin resistance increased post-operatively, as indicated by HOMA-IR (1.06 [0.73-1.93] pre-op vs. 1.63 [1.06-2.26] post-op; p = 0.002) and QUICKI (0.38 ± 0.04 pre-op vs. 0.36 ± 0.03 post-op; p = 0.006). ΔHOMA-IR and ΔQUICKI became insignificant (p = 0.101 and 0.141 respectively) after adjusting for ΔPEDF. In conclusion, the reduction in plasma estradiol levels following oophorectomy was significantly associated with increases in plasma PEDF levels and insulin resistance. Our data suggest that estradiol is a physiological regulator of PEDF expression in humans and that an increase in circulating PEDF contributes to the increase in insulin resistance in these women with estrogen deficiency following bilateral oophorectomy.
Description	Poster Presentation: abstract no. 1780-P

DC Field	Value
dc.contributor.author	Yuen, MM
dc.contributor.author	Chow, WS
dc.contributor.author	Cheng, C
dc.contributor.author	Pun, TC
dc.contributor.author	Law, LSC
dc.contributor.author	Tso, AWK
dc.contributor.author	Xu, A
dc.contributor.author	Lam, KSL
dc.date.accessioned	2011-09-23T06:11:53Z
dc.date.available	2011-09-23T06:11:53Z
dc.date.issued	2011
dc.description.abstract	Pigment epithelium-derived factor (PEDF) is implicated in murine insulin resistance and metabolic dysfunctions. Women have lower serum PEDF levels and 17β-estradiol inhibits the transcription of PEDF in human ovarian epithelial cells. To investigate whether estradiol regulates PEDF in vivo, we studied the changes in PEDF levels in 21 pre-menopausal women (age = 49.6 ± 3.5 years) following bilateral oophorectomy for benign gynaecological conditions. Body mass index (BMI), waist circumference (WC), percentage body fat, and plasma PEDF (ng/ml) and estradiol (pmol/l) levels were measured before and after oophorectomy. The changes (Δ) in PEDF, estradiol, homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI) were analyzed with repeated measure ANOVA. The mean duration between pre- and post-operative assessment was 4.0±0.7 months. BMI was marginally reduced in the post-operative period (25.2 ± 4.0 kg/m2 pre-op vs. 24.8 ± 4.3 kg/m2 post-op; p = 0.048). There were no significant changes in WC or percentage body fat The marked post-operative reduction in plasma estradiol levels (225 [109-418] pmol/l pre-op vs. 32 [19-50] pmol/l post-op; p < 0.001) was associated with increases in plasma PEDF levels (7.7 ± 1.6 ng/ml pre-op vs. 8.8 ± 1.5 ng/ml post-op; p = 0.001). An inverse relationship was found between Δestradiol and ΔPEDF (r = -0.497; p = 0.022). Insulin resistance increased post-operatively, as indicated by HOMA-IR (1.06 [0.73-1.93] pre-op vs. 1.63 [1.06-2.26] post-op; p = 0.002) and QUICKI (0.38 ± 0.04 pre-op vs. 0.36 ± 0.03 post-op; p = 0.006). ΔHOMA-IR and ΔQUICKI became insignificant (p = 0.101 and 0.141 respectively) after adjusting for ΔPEDF. In conclusion, the reduction in plasma estradiol levels following oophorectomy was significantly associated with increases in plasma PEDF levels and insulin resistance. Our data suggest that estradiol is a physiological regulator of PEDF expression in humans and that an increase in circulating PEDF contributes to the increase in insulin resistance in these women with estrogen deficiency following bilateral oophorectomy.
dc.description	Poster Presentation: abstract no. 1780-P
dc.identifier.citation	The 71st American Diabetes Association Scientific Sessions, San Diego, CA., 24-28 June 2011. [How to Cite?]
dc.identifier.hkuros	194986
dc.identifier.uri	http://hdl.handle.net/10722/140445
dc.language	eng
dc.publisher	American Diabetes Association.
dc.publisher.place	United States
dc.relation.ispartof	American Diabetes Association Scientific Sessions, 2011
dc.rights	This is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]
dc.title	Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency
dc.type	Conference_Paper

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Yuen, MM</contributor.author><contributor.author>Chow, WS</contributor.author><contributor.author>Cheng, C</contributor.author><contributor.author>Pun, TC</contributor.author><contributor.author>Law, LSC</contributor.author><contributor.author>Tso, AWK</contributor.author><contributor.author>Xu, A</contributor.author><contributor.author>Lam, KSL</contributor.author><date.accessioned>2011-09-23T06:11:53Z</date.accessioned><date.available>2011-09-23T06:11:53Z</date.available><date.issued>2011</date.issued><identifier.citation>The 71st American Diabetes Association Scientific Sessions, San Diego, CA., 24-28 June 2011.</identifier.citation><identifier.uri>http://hdl.handle.net/10722/140445</identifier.uri><description>Poster Presentation: abstract no. 1780-P</description><description.abstract>Pigment epithelium-derived factor (PEDF) is implicated in murine insulin resistance and metabolic dysfunctions. Women have lower serum PEDF levels and 17&#946;-estradiol inhibits the transcription of PEDF in human ovarian epithelial cells. To investigate whether estradiol regulates PEDF in vivo, we studied the changes in PEDF levels in 21 pre-menopausal women (age = 49.6 &#177; 3.5 years) following bilateral oophorectomy for benign gynaecological conditions. Body mass index (BMI), waist circumference (WC), percentage body fat, and plasma PEDF (ng/ml) and estradiol (pmol/l) levels were measured before and after oophorectomy. The changes (&#916;) in PEDF, estradiol, homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI) were analyzed with repeated measure ANOVA. The mean duration between pre- and post-operative assessment was 4.0&#177;0.7 months. BMI was marginally reduced in the post-operative period (25.2 &#177; 4.0 kg/m2 pre-op vs. 24.8 &#177; 4.3 kg/m2 post-op; p = 0.048). There were no significant changes in WC or percentage body fat The marked post-operative reduction in plasma estradiol levels (225 [109-418] pmol/l pre-op vs. 32 [19-50] pmol/l post-op; p &lt; 0.001) was associated with increases in plasma PEDF levels (7.7 &#177; 1.6 ng/ml pre-op vs. 8.8 &#177; 1.5 ng/ml post-op; p = 0.001). An inverse relationship was found between &#916;estradiol and &#916;PEDF (r = -0.497; p = 0.022). Insulin resistance increased post-operatively, as indicated by HOMA-IR (1.06 [0.73-1.93] pre-op vs. 1.63 [1.06-2.26] post-op; p = 0.002) and QUICKI (0.38 &#177; 0.04 pre-op vs. 0.36 &#177; 0.03 post-op; p = 0.006). &#916;HOMA-IR and &#916;QUICKI became insignificant (p = 0.101 and 0.141 respectively) after adjusting for &#916;PEDF. In conclusion, the reduction in plasma estradiol levels following oophorectomy was significantly associated with increases in plasma PEDF levels and insulin resistance. Our data suggest that estradiol is a physiological regulator of PEDF expression in humans and that an increase in circulating PEDF contributes to the increase in insulin resistance in these women with estrogen deficiency following bilateral oophorectomy.</description.abstract><language>eng</language><publisher>American Diabetes Association.</publisher><relation.ispartof>American Diabetes Association Scientific Sessions, 2011</relation.ispartof><rights>This is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]</rights><title>Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency</title><type>Conference_Paper</type><identifier.hkuros>194986</identifier.hkuros><publisher.place>United States</publisher.place></item>

Conference Paper: Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency

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