File Download

There are no files associated with this item.

Supplementary

Conference Paper: Circulating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency

TitleCirculating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiency
Authors
Issue Date2011
PublisherAmerican Diabetes Association.
Citation
The 71st American Diabetes Association Scientific Sessions, San Diego, CA., 24-28 June 2011. How to Cite?
AbstractPigment epithelium-derived factor (PEDF) is implicated in murine insulin resistance and metabolic dysfunctions. Women have lower serum PEDF levels and 17β-estradiol inhibits the transcription of PEDF in human ovarian epithelial cells. To investigate whether estradiol regulates PEDF in vivo, we studied the changes in PEDF levels in 21 pre-menopausal women (age = 49.6 ± 3.5 years) following bilateral oophorectomy for benign gynaecological conditions. Body mass index (BMI), waist circumference (WC), percentage body fat, and plasma PEDF (ng/ml) and estradiol (pmol/l) levels were measured before and after oophorectomy. The changes (Δ) in PEDF, estradiol, homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI) were analyzed with repeated measure ANOVA. The mean duration between pre- and post-operative assessment was 4.0±0.7 months. BMI was marginally reduced in the post-operative period (25.2 ± 4.0 kg/m2 pre-op vs. 24.8 ± 4.3 kg/m2 post-op; p = 0.048). There were no significant changes in WC or percentage body fat The marked post-operative reduction in plasma estradiol levels (225 [109-418] pmol/l pre-op vs. 32 [19-50] pmol/l post-op; p < 0.001) was associated with increases in plasma PEDF levels (7.7 ± 1.6 ng/ml pre-op vs. 8.8 ± 1.5 ng/ml post-op; p = 0.001). An inverse relationship was found between Δestradiol and ΔPEDF (r = -0.497; p = 0.022). Insulin resistance increased post-operatively, as indicated by HOMA-IR (1.06 [0.73-1.93] pre-op vs. 1.63 [1.06-2.26] post-op; p = 0.002) and QUICKI (0.38 ± 0.04 pre-op vs. 0.36 ± 0.03 post-op; p = 0.006). ΔHOMA-IR and ΔQUICKI became insignificant (p = 0.101 and 0.141 respectively) after adjusting for ΔPEDF. In conclusion, the reduction in plasma estradiol levels following oophorectomy was significantly associated with increases in plasma PEDF levels and insulin resistance. Our data suggest that estradiol is a physiological regulator of PEDF expression in humans and that an increase in circulating PEDF contributes to the increase in insulin resistance in these women with estrogen deficiency following bilateral oophorectomy.
DescriptionPoster Presentation: abstract no. 1780-P
Persistent Identifierhttp://hdl.handle.net/10722/140445

 

DC FieldValueLanguage
dc.contributor.authorYuen, MMen_US
dc.contributor.authorChow, WSen_US
dc.contributor.authorCheng, Cen_US
dc.contributor.authorPun, TCen_US
dc.contributor.authorLaw, LSCen_US
dc.contributor.authorTso, AWKen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2011-09-23T06:11:53Z-
dc.date.available2011-09-23T06:11:53Z-
dc.date.issued2011en_US
dc.identifier.citationThe 71st American Diabetes Association Scientific Sessions, San Diego, CA., 24-28 June 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140445-
dc.descriptionPoster Presentation: abstract no. 1780-Pen_US
dc.description.abstractPigment epithelium-derived factor (PEDF) is implicated in murine insulin resistance and metabolic dysfunctions. Women have lower serum PEDF levels and 17β-estradiol inhibits the transcription of PEDF in human ovarian epithelial cells. To investigate whether estradiol regulates PEDF in vivo, we studied the changes in PEDF levels in 21 pre-menopausal women (age = 49.6 ± 3.5 years) following bilateral oophorectomy for benign gynaecological conditions. Body mass index (BMI), waist circumference (WC), percentage body fat, and plasma PEDF (ng/ml) and estradiol (pmol/l) levels were measured before and after oophorectomy. The changes (Δ) in PEDF, estradiol, homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI) were analyzed with repeated measure ANOVA. The mean duration between pre- and post-operative assessment was 4.0±0.7 months. BMI was marginally reduced in the post-operative period (25.2 ± 4.0 kg/m2 pre-op vs. 24.8 ± 4.3 kg/m2 post-op; p = 0.048). There were no significant changes in WC or percentage body fat The marked post-operative reduction in plasma estradiol levels (225 [109-418] pmol/l pre-op vs. 32 [19-50] pmol/l post-op; p < 0.001) was associated with increases in plasma PEDF levels (7.7 ± 1.6 ng/ml pre-op vs. 8.8 ± 1.5 ng/ml post-op; p = 0.001). An inverse relationship was found between Δestradiol and ΔPEDF (r = -0.497; p = 0.022). Insulin resistance increased post-operatively, as indicated by HOMA-IR (1.06 [0.73-1.93] pre-op vs. 1.63 [1.06-2.26] post-op; p = 0.002) and QUICKI (0.38 ± 0.04 pre-op vs. 0.36 ± 0.03 post-op; p = 0.006). ΔHOMA-IR and ΔQUICKI became insignificant (p = 0.101 and 0.141 respectively) after adjusting for ΔPEDF. In conclusion, the reduction in plasma estradiol levels following oophorectomy was significantly associated with increases in plasma PEDF levels and insulin resistance. Our data suggest that estradiol is a physiological regulator of PEDF expression in humans and that an increase in circulating PEDF contributes to the increase in insulin resistance in these women with estrogen deficiency following bilateral oophorectomy.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association.-
dc.relation.ispartofAmerican Diabetes Association Scientific Sessions, 2011en_US
dc.rightsThis is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]-
dc.titleCirculating plasma pigment epithelium-derived factor (PEDF) levels are associated with insulin resistance in women with estrogen deficiencyen_US
dc.typeConference_Paperen_US
dc.identifier.emailChow, WS: chowws01@hkucc.hku.hken_US
dc.identifier.emailCheng, C: endocc@hku.hken_US
dc.identifier.emailPun, TC: puntc@hkucc.hku.hken_US
dc.identifier.emailLaw, LSC: sclaw@alumni.cuhk.neten_US
dc.identifier.emailTso, AWK: awktso@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityTso, AWK=rp00535en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.hkuros194986en_US
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats