Supplementary

Conference Paper: Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development
  • Basic View
  • Metadata View
  • XML View
TitleMendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development
 
AuthorsCheung, BMY
Ong, KL
Tso, AWK
Leung, YH
Cherny, SS
Sham, PC
Thomas, GN
Lam, TH
Lam, KSL
 
Issue Date2011
 
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
CitationThe 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 22 January 2011. In the Hong Kong Medical Journal, 2011, v. 17 n. 1, Suppl. 1, p. 18, abstract no. 17 [How to Cite?]
 
AbstractIntroduction: Interleukin-6 (IL-6) plays a central role in inflammation and insulin resistance as well as atherogenesis. We investigated the associations of plasma IL-6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods: Plasma IL-6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004 and three tagging SNPs in the IL-6 gene (IL6) were genotyped. Among subjects normotensive in CRISPS-2, 515 subjects were followed up in CRISPS-3 in 2005- 2008 and 100 of them had developed hypertension. Results: Plasma IL-6 correlated with systolic blood pressure (r=0.128, P<0.001), pulse pressure (r=0.144, P<0.001), and mean arterial pressure (r=0.086, P=0.008). Hypertensive subjects have significantly higher plasma IL-6 level after adjusting for age and sex (geometric mean [95% CI]=0.60 [0.54-0.65] vs 0.47 [0.44-0.50] pg/mL, P=0.021). In stepwise logistic regression, plasma IL-6 was associated with hypertension in women (P=0.004), but not in men. The SNP rs1800796 was associated with plasma IL-6 (beta= –0.098, P=0.002) in stepwise linear regression. However, this SNP was not associated with hypertension or blood pressure. Among subjects normotensive in CRISPS-2, plasma IL-6 was not associated with the development of hypertension in CRISPS-3. Conclusion: Elevated plasma IL-6 is associated with hypertension, especially in women. Plasma IL-6 is influenced by the SNP rs1800796. However, this SNP is not associated with hypertension, suggesting that hypertension is caused by other factors that elevate plasma IL-6. Acknowledgement: This study was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.
 
ISSN1024-2708
2013 SCImago Journal Rankings: 0.293
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, YH
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorThomas, GN
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-09-23T06:08:06Z
 
dc.date.available2011-09-23T06:08:06Z
 
dc.date.issued2011
 
dc.description.abstractIntroduction: Interleukin-6 (IL-6) plays a central role in inflammation and insulin resistance as well as atherogenesis. We investigated the associations of plasma IL-6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods: Plasma IL-6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004 and three tagging SNPs in the IL-6 gene (IL6) were genotyped. Among subjects normotensive in CRISPS-2, 515 subjects were followed up in CRISPS-3 in 2005- 2008 and 100 of them had developed hypertension. Results: Plasma IL-6 correlated with systolic blood pressure (r=0.128, P<0.001), pulse pressure (r=0.144, P<0.001), and mean arterial pressure (r=0.086, P=0.008). Hypertensive subjects have significantly higher plasma IL-6 level after adjusting for age and sex (geometric mean [95% CI]=0.60 [0.54-0.65] vs 0.47 [0.44-0.50] pg/mL, P=0.021). In stepwise logistic regression, plasma IL-6 was associated with hypertension in women (P=0.004), but not in men. The SNP rs1800796 was associated with plasma IL-6 (beta= –0.098, P=0.002) in stepwise linear regression. However, this SNP was not associated with hypertension or blood pressure. Among subjects normotensive in CRISPS-2, plasma IL-6 was not associated with the development of hypertension in CRISPS-3. Conclusion: Elevated plasma IL-6 is associated with hypertension, especially in women. Plasma IL-6 is influenced by the SNP rs1800796. However, this SNP is not associated with hypertension, suggesting that hypertension is caused by other factors that elevate plasma IL-6. Acknowledgement: This study was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationThe 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 22 January 2011. In the Hong Kong Medical Journal, 2011, v. 17 n. 1, Suppl. 1, p. 18, abstract no. 17 [How to Cite?]
 
dc.identifier.epage18, abstract no. 17
 
dc.identifier.hkuros194407
 
dc.identifier.issn1024-2708
2013 SCImago Journal Rankings: 0.293
 
dc.identifier.issue1, Suppl. 1
 
dc.identifier.spage18, abstract no. 17
 
dc.identifier.urihttp://hdl.handle.net/10722/140171
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Medical Journal
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleMendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development
 
dc.typeConference_Paper
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Cheung, BMY</contributor.author>
<contributor.author>Ong, KL</contributor.author>
<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Leung, YH</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Thomas, GN</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<date.accessioned>2011-09-23T06:08:06Z</date.accessioned>
<date.available>2011-09-23T06:08:06Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>The 16th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 22 January 2011. In the Hong Kong Medical Journal, 2011, v. 17  n. 1, Suppl. 1, p. 18, abstract no. 17</identifier.citation>
<identifier.issn>1024-2708</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/140171</identifier.uri>
<description.abstract>Introduction: Interleukin-6 (IL-6) plays a central role in inflammation and insulin resistance as well as atherogenesis.
We investigated the associations of plasma IL-6 and its genetic variants with hypertension in both cross-sectional and
prospective study designs.
Methods: Plasma IL-6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong
Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2) in 2000-2004 and three tagging SNPs in the IL-6 gene (IL6)
were genotyped. Among subjects normotensive in CRISPS-2, 515 subjects were followed up in CRISPS-3 in 2005-
2008 and 100 of them had developed hypertension.
Results: Plasma IL-6 correlated with systolic blood pressure (r=0.128, P&lt;0.001), pulse pressure (r=0.144, P&lt;0.001),
and mean arterial pressure (r=0.086, P=0.008). Hypertensive subjects have significantly higher plasma IL-6 level
after adjusting for age and sex (geometric mean [95% CI]=0.60 [0.54-0.65] vs 0.47 [0.44-0.50] pg/mL, P=0.021). In
stepwise logistic regression, plasma IL-6 was associated with hypertension in women (P=0.004), but not in men. The
SNP rs1800796 was associated with plasma IL-6 (beta= &#8211;0.098, P=0.002) in stepwise linear regression. However, this
SNP was not associated with hypertension or blood pressure. Among subjects normotensive in CRISPS-2, plasma IL-6
was not associated with the development of hypertension in CRISPS-3.
Conclusion: Elevated plasma IL-6 is associated with hypertension, especially in women. Plasma IL-6 is influenced by
the SNP rs1800796. However, this SNP is not associated with hypertension, suggesting that hypertension is caused by
other factors that elevate plasma IL-6.
Acknowledgement: This study was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M)
and the Sun Chieh Yeh Heart Foundation.</description.abstract>
<language>eng</language>
<publisher>Hong Kong Academy of Medicine Press. The Journal&apos;s web site is located at http://www.hkmj.org.hk</publisher>
<relation.ispartof>Hong Kong Medical Journal</relation.ispartof>
<rights>Hong Kong Medical Journal. Copyright &#169; Hong Kong Academy of Medicine Press.</rights>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<title>Mendelian randomisation analysis suggests that plasma interleukin-6 is raised in hypertension but does not cause its development</title>
<type>Conference_Paper</type>
<description.nature>published_or_final_version</description.nature>
<identifier.hkuros>194407</identifier.hkuros>
<identifier.volume>17</identifier.volume>
<identifier.issue>1, Suppl. 1</identifier.issue>
<identifier.spage>18, abstract no. 17</identifier.spage>
<identifier.epage>18, abstract no. 17</identifier.epage>
<publisher.place>Hong Kong</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/140171/1/Abstract.pdf</bitstream.url>
</item>