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Conference Paper: Generation of induced pluripotent stem (iPS) cells from bone-forming cells

TitleGeneration of induced pluripotent stem (iPS) cells from bone-forming cells
Authors
Issue Date2011
PublisherThe University of Hong Kong.
Citation
The 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 11 June 2011. How to Cite?
AbstractOsteochondroprogenitors uniquely co-expressing Sox9 and Runx2 with dual differentiation potential to become chondrocytes and osteoblasts is an ideal candidate for cell-based therapy. Therefore, developing approaches to generate sufficient amounts of osteochondroprogenitors for skeletal regenerative medicine are essential. Towards this, we take advantage of a reprogramming approach - induced pluripotent stem (iPS) cells generation using osteoblasts. The selection of osteoblasts is based on the hypothesis that it is originally derived from osteochondroprogenitor lineage and the stochastic events of iPS induction might revert osteoblasts first to their progenitor state before becoming pluripotent. Sox9/Runx2 reporter mice will be generated using their regulatory sequences to drive separate drug selection markers (neomycin and blasticidin) and two fluorescence proteins (eYFP and mCherry) for identification and selection of osteochondroprogenitors during reprogramming.
DescriptionPoster Presentation: P-H012
Symposium URL at http://www.biochem.hku.hk/postgraduate/symposium2011/
Persistent Identifierhttp://hdl.handle.net/10722/140090

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_US
dc.contributor.authorLu, Len_US
dc.contributor.authorWu, MHen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorCheah, KSEen_US
dc.contributor.authorSham, MHen_US
dc.date.accessioned2011-09-23T06:06:30Z-
dc.date.available2011-09-23T06:06:30Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 11 June 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140090-
dc.descriptionPoster Presentation: P-H012-
dc.descriptionSymposium URL at http://www.biochem.hku.hk/postgraduate/symposium2011/-
dc.description.abstractOsteochondroprogenitors uniquely co-expressing Sox9 and Runx2 with dual differentiation potential to become chondrocytes and osteoblasts is an ideal candidate for cell-based therapy. Therefore, developing approaches to generate sufficient amounts of osteochondroprogenitors for skeletal regenerative medicine are essential. Towards this, we take advantage of a reprogramming approach - induced pluripotent stem (iPS) cells generation using osteoblasts. The selection of osteoblasts is based on the hypothesis that it is originally derived from osteochondroprogenitor lineage and the stochastic events of iPS induction might revert osteoblasts first to their progenitor state before becoming pluripotent. Sox9/Runx2 reporter mice will be generated using their regulatory sequences to drive separate drug selection markers (neomycin and blasticidin) and two fluorescence proteins (eYFP and mCherry) for identification and selection of osteochondroprogenitors during reprogramming.-
dc.languageengen_US
dc.publisherThe University of Hong Kong.-
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposium, 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleGeneration of induced pluripotent stem (iPS) cells from bone-forming cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, Y: h0894106@HKUSUC.hku.hken_US
dc.identifier.emailLu, L: waywaywise@gmail.comen_US
dc.identifier.emailWu, MH: ronmhwu@hkucc.hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.emailSham, MH: mhsham@hku.hk-
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityCheah, KSE=rp00342en_US
dc.identifier.authoritySham, MH=rp00380en_US
dc.description.naturepostprint-
dc.identifier.hkuros192722en_US
dc.publisher.placeHong Kong-
dc.description.otherThe 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 11 June 2011.-

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