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Article: Psychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: A prospective study

TitlePsychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: A prospective study
Authors
Keywordsatypical cytology
Chinese
Gynecologic oncology
HPV testing
psychology
women's health issues
Issue Date2011
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412
Citation
Acta Obstetricia Et Gynecologica Scandinavica, 2011, v. 90 n. 5, p. 445-451 How to Cite?
AbstractObjective. To assess the psychological burden of testing positive for high-risk human papillomavirus (HPV) on Chinese women with atypical squamous cells of undetermined significance (ASCUS). Design. Prospective observational study. Setting. Five community women's health clinics in Hong Kong. Population. Ethnic Chinese women (n=299) with ASCUS who underwent reflex HPV testing (of whom 142 tested HPV negative and 157 tested HPV positive). Methods. Women's psychological condition was assessed by self-administered questionnaires at smear result notification and by structured telephone interviews six months after notification. All women who tested positive for HPV were referred for colposcopy. Main outcome measures. State anxiety, cervical cancer worry and psychosocial burden. Results. At result notification, the HPV-positive group had significantly higher state anxiety, cervical cancer worry and psychosocial burden than the HPV-negative group (all p<0.001). Irrespective of the HPV results, all outcome scores decreased over time. About 80% of the women who were HPV positive attended colposcopy as recommended. At six months, the two groups did not differ in state anxiety, cervical cancer worry, perceived risk of cervical cancer and satisfaction with intimate relationship, but psychosocial burden remained higher in the HPV-positive group (p=0.001). Conclusions. A concurrent positive HPV result intensified the distress of women with ASCUS at result notification. With time and after colposcopy, their initial heightened anxiety and cervical cancer worry were significantly lowered. However, HPV positivity may pose a prolonged psychosocial burden on women even after having had the necessary follow-up for their cervical abnormalities. © 2011 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/139936
ISSN
2015 Impact Factor: 2.191
2015 SCImago Journal Rankings: 1.197
ISI Accession Number ID
Funding AgencyGrant Number
Department of Obstetrics and Gynaecology
University of Hong Kong
Wong Check She Charitable Foundation
Merck Co., Inc.
Funding Information:

This study was jointly funded by The Research Fund of the Department of Obstetrics and Gynaecology, The University of Hong Kong, The Wong Check She Charitable Foundation and a research grant from the Investigator Initiated Studies Program of Merck & Co., Inc. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck & Co., Inc.

References

 

DC FieldValueLanguage
dc.contributor.authorKwan, TTCen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLo, SSTen_HK
dc.contributor.authorLee, PWHen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2011-09-23T06:02:00Z-
dc.date.available2011-09-23T06:02:00Z-
dc.date.issued2011en_HK
dc.identifier.citationActa Obstetricia Et Gynecologica Scandinavica, 2011, v. 90 n. 5, p. 445-451en_HK
dc.identifier.issn0001-6349en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139936-
dc.description.abstractObjective. To assess the psychological burden of testing positive for high-risk human papillomavirus (HPV) on Chinese women with atypical squamous cells of undetermined significance (ASCUS). Design. Prospective observational study. Setting. Five community women's health clinics in Hong Kong. Population. Ethnic Chinese women (n=299) with ASCUS who underwent reflex HPV testing (of whom 142 tested HPV negative and 157 tested HPV positive). Methods. Women's psychological condition was assessed by self-administered questionnaires at smear result notification and by structured telephone interviews six months after notification. All women who tested positive for HPV were referred for colposcopy. Main outcome measures. State anxiety, cervical cancer worry and psychosocial burden. Results. At result notification, the HPV-positive group had significantly higher state anxiety, cervical cancer worry and psychosocial burden than the HPV-negative group (all p<0.001). Irrespective of the HPV results, all outcome scores decreased over time. About 80% of the women who were HPV positive attended colposcopy as recommended. At six months, the two groups did not differ in state anxiety, cervical cancer worry, perceived risk of cervical cancer and satisfaction with intimate relationship, but psychosocial burden remained higher in the HPV-positive group (p=0.001). Conclusions. A concurrent positive HPV result intensified the distress of women with ASCUS at result notification. With time and after colposcopy, their initial heightened anxiety and cervical cancer worry were significantly lowered. However, HPV positivity may pose a prolonged psychosocial burden on women even after having had the necessary follow-up for their cervical abnormalities. © 2011 The Authors.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412en_HK
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavicaen_HK
dc.rightsActa Obstetricia et Gynecologica Scandinavica. Copyright © John Wiley & Sons Ltd.-
dc.subjectatypical cytologyen_HK
dc.subjectChineseen_HK
dc.subjectGynecologic oncologyen_HK
dc.subjectHPV testingen_HK
dc.subjectpsychologyen_HK
dc.subjectwomen's health issuesen_HK
dc.subject.meshAlphapapillomavirus - isolation and purification-
dc.subject.meshAnxiety - etiology-
dc.subject.meshCervix Uteri - pathology - virology-
dc.subject.meshPapillomavirus Infections - diagnosis - psychology-
dc.subject.meshStress, Psychological - etiology-
dc.titlePsychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-6349&volume=90&issue=5&spage=445&epage=451&date=2011&atitle=Psychological+burden+of+testing+positive+for+high-risk+human+papillomavirus+on+women+with+atypical+cervical+cytology:+a+prospective+study-
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0412.2011.01092.xen_HK
dc.identifier.pmid21306349-
dc.identifier.scopuseid_2-s2.0-79955069223en_HK
dc.identifier.hkuros192488en_US
dc.identifier.hkuros190746-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955069223&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue5en_HK
dc.identifier.spage445en_HK
dc.identifier.epage451en_HK
dc.identifier.isiWOS:000290360100005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwan, TTC=16063821800en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLo, SST=8718876900en_HK
dc.identifier.scopusauthoridLee, PWH=7406120357en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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