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Article: Gender differences in patients presenting with first-episode psychosis in Hong Kong: A three-year follow up study

TitleGender differences in patients presenting with first-episode psychosis in Hong Kong: A three-year follow up study
Authors
Keywordsfirst-episode psychosis
functioning
gender
schizophrenia
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
Citation
Australian And New Zealand Journal Of Psychiatry, 2011, v. 45 n. 3, p. 199-205 How to Cite?
AbstractObjective: The aim of the current study was to investigate gender differences with respect to pre-treatment characteristics, clinical presentation, service utilization and functional outcome in patients presenting with first-episode psychosis. Methods: A total of 700 participants (men, n = 360; women, n = 340) aged 15 to 25 years consecutively enrolled in a territory-wide first-episode psychosis treatment programme in Hong Kong from July 2001 to August 2003 were studied. Baseline and three-year follow up variables were collected via systematic medical file review. Results: At service entry, men had significantly lower educational attainment (p < 0.01), longer median duration of untreated psychosis (p < 0.001), fewer past suicidal attempts (p < 0.01), more severe negative symptoms (p < 0.05) and fewer affective symptoms (p < 0.01) than women. There was no significant gender difference in age of onset. In three-year follow up, men had more prominent negative symptoms (p < 0.001), fewer affective symptoms (p < 0.01), more violent behaviour and forensic records (p < 0.01), and higher rate of substance abuse (p < 0.01). Women achieved higher levels of functioning than men (Social Occupational Functioning Assessment Scale (SOFAS), p < 0.001) and a significantly higher proportion of women than men engaged in full-time employment or study for at least 12 consecutive months (p < 0.001) in the initial three years after psychiatric treatment. Conclusion: Notable gender differences in clinical profiles, illness trajectory and functional outcome were demonstrated in Chinese young people suffering from first-episode psychosis. Differential needs between men and women and hence gender-specific therapeutic strategies should be considered in early intervention service. © 2011 The Royal Australian and New Zealand College of Psychiatrists.
Persistent Identifierhttp://hdl.handle.net/10722/139680
ISSN
2015 Impact Factor: 3.536
2015 SCImago Journal Rankings: 1.269
ISI Accession Number ID
Funding AgencyGrant Number
Health and Health Service Research Fund of Food and Health Bureau03041041
Government of Hong Kong Special Administrative Region
Janssen-Cilag
Astra-Zeneca
Eli Lilly
Sanofi-Aventis
Otsuka
Funding Information:

The study was part of the historical case-controlled study of first-episode psychosis which was supported by a grant from the Health and Health Service Research Fund (03041041) of the Food and Health Bureau, the Government of Hong Kong Special Administrative Region. Author E.Y.H.C. has participated in the paid advisory board for Otsuka, has received educational grant support from Janssen-Cilag, and has received research funding from Astra-Zeneca, Janssen-Cilag, Eli Lilly, Sanofi-Aventis and Otsuka; Author M. M. L. L. has done consultancy for Otsuka and Eli Lilly. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

References

 

DC FieldValueLanguage
dc.contributor.authorChang, WCen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChung, DWSen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorTso, Sen_HK
dc.contributor.authorChan, KPMen_HK
dc.contributor.authorHung, SFen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2011-09-23T05:54:00Z-
dc.date.available2011-09-23T05:54:00Z-
dc.date.issued2011en_HK
dc.identifier.citationAustralian And New Zealand Journal Of Psychiatry, 2011, v. 45 n. 3, p. 199-205en_HK
dc.identifier.issn0004-8674en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139680-
dc.description.abstractObjective: The aim of the current study was to investigate gender differences with respect to pre-treatment characteristics, clinical presentation, service utilization and functional outcome in patients presenting with first-episode psychosis. Methods: A total of 700 participants (men, n = 360; women, n = 340) aged 15 to 25 years consecutively enrolled in a territory-wide first-episode psychosis treatment programme in Hong Kong from July 2001 to August 2003 were studied. Baseline and three-year follow up variables were collected via systematic medical file review. Results: At service entry, men had significantly lower educational attainment (p < 0.01), longer median duration of untreated psychosis (p < 0.001), fewer past suicidal attempts (p < 0.01), more severe negative symptoms (p < 0.05) and fewer affective symptoms (p < 0.01) than women. There was no significant gender difference in age of onset. In three-year follow up, men had more prominent negative symptoms (p < 0.001), fewer affective symptoms (p < 0.01), more violent behaviour and forensic records (p < 0.01), and higher rate of substance abuse (p < 0.01). Women achieved higher levels of functioning than men (Social Occupational Functioning Assessment Scale (SOFAS), p < 0.001) and a significantly higher proportion of women than men engaged in full-time employment or study for at least 12 consecutive months (p < 0.001) in the initial three years after psychiatric treatment. Conclusion: Notable gender differences in clinical profiles, illness trajectory and functional outcome were demonstrated in Chinese young people suffering from first-episode psychosis. Differential needs between men and women and hence gender-specific therapeutic strategies should be considered in early intervention service. © 2011 The Royal Australian and New Zealand College of Psychiatrists.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anpen_HK
dc.relation.ispartofAustralian and New Zealand Journal of Psychiatryen_HK
dc.rightsAustralian & New Zealand Journal of Psychiatry. Copyright © Informa Healthcare.-
dc.subjectfirst-episode psychosisen_HK
dc.subjectfunctioningen_HK
dc.subjectgenderen_HK
dc.subjectschizophreniaen_HK
dc.subject.meshHong Kong-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshPsychotic Disorders - diagnosis - psychology-
dc.subject.meshSex Characteristics-
dc.subject.meshSuicide, Attempted - psychology-
dc.titleGender differences in patients presenting with first-episode psychosis in Hong Kong: A three-year follow up studyen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, WC: changwc@hku.hken_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChang, WC=rp01465en_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/00048674.2010.547841en_HK
dc.identifier.pmid21261552-
dc.identifier.scopuseid_2-s2.0-79952305594en_HK
dc.identifier.hkuros194591en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952305594&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue3en_HK
dc.identifier.spage199en_HK
dc.identifier.epage205en_HK
dc.identifier.eissn1440-1614-
dc.identifier.isiWOS:000287742800004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChang, WC=26643706700en_HK
dc.identifier.scopusauthoridTang, JYM=35086815700en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChung, DWS=7401719312en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridTso, S=25229476600en_HK
dc.identifier.scopusauthoridChan, KPM=16204769300en_HK
dc.identifier.scopusauthoridHung, SF=7201936267en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK

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