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Article: Circulating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot
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TitleCirculating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot
 
AuthorsLai, CTM1
Chan, KW1
Wong, SJ1
Chow, PC1
Cheung, YF1
 
Issue Date2011
 
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahj
 
CitationAmerican Heart Journal, 2011, v. 162 n. 3, p. 467-473 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ahj.2011.05.027
 
AbstractBACKGROUND: Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are biomarkers of collagen synthesis. We tested the hypothesis that circulating PICP and PIIINP are altered and may correlate with ventricular volume load and function in patients with repaired tetralogy of Fallot (TOF). METHODS AND RESULTS: Serum PICP and plasma PIIINP levels were determined in 39 patients with repaired TOF aged 17.7 +/- 4.1 years and 25 healthy controls and correlated with right ventricular (RV) and left ventricular (LV) volumes, functional indices, and mechanical dyssynchrony as assessed by 3-dimensional and tissue Doppler echocardiography. Compared with controls, patients had significantly higher circulating PICP (P = .016) and PIIINP (P = .008) levels, worse RV function with intra-RV mechanical delay (all P < .001), impaired LV systolic functional indices (all P < .05), and greater LV systolic dyssynchrony index (SDI) (P < .001). For the whole cohort, circulating PICP and PIIINP levels correlated with age (P = .001 and P < .001, respectively), body mass index (P = .033 and P = .012, respectively), LV eccentricity (P = .035 and P = .046, respectively), RV end-diastolic volume (P = .029 and P = .047, respectively), and LV SDI (both P < .001). In addition, PICP levels correlated negatively with RV and LV isovolumic acceleration and RV ejection fraction. Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (beta = .31, P = .045) and PIIINP (beta = .37, P = .004). CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in patients after TOF repair, implicating a possible role of increased collagen synthesis in its pathogenesis.
 
ISSN0002-8703
2013 Impact Factor: 4.555
 
DOIhttp://dx.doi.org/10.1016/j.ahj.2011.05.027
 
ISI Accession Number IDWOS:000294447400008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLai, CTM
 
dc.contributor.authorChan, KW
 
dc.contributor.authorWong, SJ
 
dc.contributor.authorChow, PC
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2011-09-23T05:51:59Z
 
dc.date.available2011-09-23T05:51:59Z
 
dc.date.issued2011
 
dc.description.abstractBACKGROUND: Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are biomarkers of collagen synthesis. We tested the hypothesis that circulating PICP and PIIINP are altered and may correlate with ventricular volume load and function in patients with repaired tetralogy of Fallot (TOF). METHODS AND RESULTS: Serum PICP and plasma PIIINP levels were determined in 39 patients with repaired TOF aged 17.7 +/- 4.1 years and 25 healthy controls and correlated with right ventricular (RV) and left ventricular (LV) volumes, functional indices, and mechanical dyssynchrony as assessed by 3-dimensional and tissue Doppler echocardiography. Compared with controls, patients had significantly higher circulating PICP (P = .016) and PIIINP (P = .008) levels, worse RV function with intra-RV mechanical delay (all P < .001), impaired LV systolic functional indices (all P < .05), and greater LV systolic dyssynchrony index (SDI) (P < .001). For the whole cohort, circulating PICP and PIIINP levels correlated with age (P = .001 and P < .001, respectively), body mass index (P = .033 and P = .012, respectively), LV eccentricity (P = .035 and P = .046, respectively), RV end-diastolic volume (P = .029 and P = .047, respectively), and LV SDI (both P < .001). In addition, PICP levels correlated negatively with RV and LV isovolumic acceleration and RV ejection fraction. Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (beta = .31, P = .045) and PIIINP (beta = .37, P = .004). CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in patients after TOF repair, implicating a possible role of increased collagen synthesis in its pathogenesis.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Heart Journal, 2011, v. 162 n. 3, p. 467-473 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ahj.2011.05.027
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ahj.2011.05.027
 
dc.identifier.epage473
 
dc.identifier.hkuros195125
 
dc.identifier.isiWOS:000294447400008
 
dc.identifier.issn0002-8703
2013 Impact Factor: 4.555
 
dc.identifier.issue3
 
dc.identifier.pmid21884862
 
dc.identifier.scopuseid_2-s2.0-80052300487
 
dc.identifier.spage467
 
dc.identifier.urihttp://hdl.handle.net/10722/139579
 
dc.identifier.volume162
 
dc.languageeng
 
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahj
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Heart Journal
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCollagen - biosynthesis
 
dc.subject.meshPeptide Fragments - blood
 
dc.subject.meshProcollagen - blood
 
dc.subject.meshTetralogy of Fallot - complications - surgery
 
dc.subject.meshVentricular Dysfunction, Left - blood - etiology - physiopathology
 
dc.titleCirculating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot
 
dc.typeArticle
 
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<contributor.author>Chan, KW</contributor.author>
<contributor.author>Wong, SJ</contributor.author>
<contributor.author>Chow, PC</contributor.author>
<contributor.author>Cheung, YF</contributor.author>
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<description.abstract>BACKGROUND: Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are biomarkers of collagen synthesis. We tested the hypothesis that circulating PICP and PIIINP are altered and may correlate with ventricular volume load and function in patients with repaired tetralogy of Fallot (TOF). METHODS AND RESULTS: Serum PICP and plasma PIIINP levels were determined in 39 patients with repaired TOF aged 17.7 +/- 4.1 years and 25 healthy controls and correlated with right ventricular (RV) and left ventricular (LV) volumes, functional indices, and mechanical dyssynchrony as assessed by 3-dimensional and tissue Doppler echocardiography. Compared with controls, patients had significantly higher circulating PICP (P = .016) and PIIINP (P = .008) levels, worse RV function with intra-RV mechanical delay (all P &lt; .001), impaired LV systolic functional indices (all P &lt; .05), and greater LV systolic dyssynchrony index (SDI) (P &lt; .001). For the whole cohort, circulating PICP and PIIINP levels correlated with age (P = .001 and P &lt; .001, respectively), body mass index (P = .033 and P = .012, respectively), LV eccentricity (P = .035 and P = .046, respectively), RV end-diastolic volume (P = .029 and P = .047, respectively), and LV SDI (both P &lt; .001). In addition, PICP levels correlated negatively with RV and LV isovolumic acceleration and RV ejection fraction. Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (beta = .31, P = .045) and PIIINP (beta = .37, P = .004). CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in patients after TOF repair, implicating a possible role of increased collagen synthesis in its pathogenesis.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong