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Article: Circulating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot

TitleCirculating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Fallot
Authors
Issue Date2011
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahj
Citation
American Heart Journal, 2011, v. 162 n. 3, p. 467-473 How to Cite?
Abstract
BACKGROUND: Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are biomarkers of collagen synthesis. We tested the hypothesis that circulating PICP and PIIINP are altered and may correlate with ventricular volume load and function in patients with repaired tetralogy of Fallot (TOF). METHODS AND RESULTS: Serum PICP and plasma PIIINP levels were determined in 39 patients with repaired TOF aged 17.7 +/- 4.1 years and 25 healthy controls and correlated with right ventricular (RV) and left ventricular (LV) volumes, functional indices, and mechanical dyssynchrony as assessed by 3-dimensional and tissue Doppler echocardiography. Compared with controls, patients had significantly higher circulating PICP (P = .016) and PIIINP (P = .008) levels, worse RV function with intra-RV mechanical delay (all P < .001), impaired LV systolic functional indices (all P < .05), and greater LV systolic dyssynchrony index (SDI) (P < .001). For the whole cohort, circulating PICP and PIIINP levels correlated with age (P = .001 and P < .001, respectively), body mass index (P = .033 and P = .012, respectively), LV eccentricity (P = .035 and P = .046, respectively), RV end-diastolic volume (P = .029 and P = .047, respectively), and LV SDI (both P < .001). In addition, PICP levels correlated negatively with RV and LV isovolumic acceleration and RV ejection fraction. Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (beta = .31, P = .045) and PIIINP (beta = .37, P = .004). CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in patients after TOF repair, implicating a possible role of increased collagen synthesis in its pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/139579
ISSN
2013 Impact Factor: 4.555
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CTMen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorChow, PCen_HK
dc.contributor.authorCheung, YFen_HK
dc.date.accessioned2011-09-23T05:51:59Z-
dc.date.available2011-09-23T05:51:59Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Heart Journal, 2011, v. 162 n. 3, p. 467-473en_HK
dc.identifier.issn0002-8703en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139579-
dc.description.abstractBACKGROUND: Circulating carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) are biomarkers of collagen synthesis. We tested the hypothesis that circulating PICP and PIIINP are altered and may correlate with ventricular volume load and function in patients with repaired tetralogy of Fallot (TOF). METHODS AND RESULTS: Serum PICP and plasma PIIINP levels were determined in 39 patients with repaired TOF aged 17.7 +/- 4.1 years and 25 healthy controls and correlated with right ventricular (RV) and left ventricular (LV) volumes, functional indices, and mechanical dyssynchrony as assessed by 3-dimensional and tissue Doppler echocardiography. Compared with controls, patients had significantly higher circulating PICP (P = .016) and PIIINP (P = .008) levels, worse RV function with intra-RV mechanical delay (all P < .001), impaired LV systolic functional indices (all P < .05), and greater LV systolic dyssynchrony index (SDI) (P < .001). For the whole cohort, circulating PICP and PIIINP levels correlated with age (P = .001 and P < .001, respectively), body mass index (P = .033 and P = .012, respectively), LV eccentricity (P = .035 and P = .046, respectively), RV end-diastolic volume (P = .029 and P = .047, respectively), and LV SDI (both P < .001). In addition, PICP levels correlated negatively with RV and LV isovolumic acceleration and RV ejection fraction. Multiple linear regression analysis identified LV SDI as a significant independent correlate of circulating levels of PICP (beta = .31, P = .045) and PIIINP (beta = .37, P = .004). CONCLUSION: Circulating levels of PICP and PIIINP correlate positively with LV mechanical dyssynchrony in patients after TOF repair, implicating a possible role of increased collagen synthesis in its pathogenesis.en_HK
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahjen_HK
dc.relation.ispartofAmerican Heart Journalen_HK
dc.subject.meshCollagen - biosynthesis-
dc.subject.meshPeptide Fragments - blood-
dc.subject.meshProcollagen - blood-
dc.subject.meshTetralogy of Fallot - complications - surgery-
dc.subject.meshVentricular Dysfunction, Left - blood - etiology - physiopathology-
dc.titleCirculating levels of biomarkers of collagen synthesis and ventricular function and dyssynchrony in adolescents and young adults after repair of tetralogy of Falloten_HK
dc.typeArticleen_HK
dc.identifier.emailLai, CTM: clarelai@hku.hken_HK
dc.identifier.emailChan, KW: kwchan@hku.hk-
dc.identifier.emailWong, SJ: sjwong@hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ahj.2011.05.027en_HK
dc.identifier.pmid21884862en_HK
dc.identifier.scopuseid_2-s2.0-80052300487en_HK
dc.identifier.hkuros195125en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052300487&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume162en_HK
dc.identifier.issue3en_HK
dc.identifier.spage467en_HK
dc.identifier.epage473en_HK
dc.identifier.isiWOS:000294447400008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridChow, PC=23099233800en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridChan, KW=8587755300en_HK
dc.identifier.scopusauthoridLai, CTM=54389305900en_HK

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