File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
  • Basic View
  • Metadata View
  • XML View
TitleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
 
AuthorsCheung, YF1
Hong, WJ1
Chan, KW1
Wong, SJ1
 
KeywordsAortic stiffness
Matrix metalloproteinase polymorphism
Tetralogy of Fallot
 
Issue Date2011
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
CitationInternational Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2010.05.046
 
AbstractMatrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.
 
ISSN0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
DOIhttp://dx.doi.org/10.1016/j.ijcard.2010.05.046
 
ISI Accession Number IDWOS:000294476300031
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, YF
 
dc.contributor.authorHong, WJ
 
dc.contributor.authorChan, KW
 
dc.contributor.authorWong, SJ
 
dc.date.accessioned2011-09-23T05:51:58Z
 
dc.date.available2011-09-23T05:51:58Z
 
dc.date.issued2011
 
dc.description.abstractMatrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2010.05.046
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2010.05.046
 
dc.identifier.epage217
 
dc.identifier.hkuros194873
 
dc.identifier.isiWOS:000294476300031
 
dc.identifier.issn0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid20541269
 
dc.identifier.scopuseid_2-s2.0-80052308514
 
dc.identifier.spage214
 
dc.identifier.urihttp://hdl.handle.net/10722/139578
 
dc.identifier.volume151
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
dc.publisher.placeIreland
 
dc.relation.ispartofInternational Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAortic stiffness
 
dc.subjectMatrix metalloproteinase polymorphism
 
dc.subjectTetralogy of Fallot
 
dc.titleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Cheung, YF</contributor.author>
<contributor.author>Hong, WJ</contributor.author>
<contributor.author>Chan, KW</contributor.author>
<contributor.author>Wong, SJ</contributor.author>
<date.accessioned>2011-09-23T05:51:58Z</date.accessioned>
<date.available>2011-09-23T05:51:58Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>International Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217</identifier.citation>
<identifier.issn>0167-5273</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/139578</identifier.uri>
<description.abstract>Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C &gt; T polymorphism in 79 TOF patients aged 19.9 &#177; 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p &gt; 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (&#946; = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. &#169; 2010 Elsevier Ireland Ltd.</description.abstract>
<language>eng</language>
<publisher>Elsevier Ireland Ltd. The Journal&apos;s web site is located at http://www.elsevier.com/locate/ijcard</publisher>
<relation.ispartof>International Journal of Cardiology</relation.ispartof>
<subject>Aortic stiffness</subject>
<subject>Matrix metalloproteinase polymorphism</subject>
<subject>Tetralogy of Fallot</subject>
<title>Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0167-5273&amp;volume=151&amp;issue=2&amp;spage=214&amp;epage=217&amp;date=2011&amp;atitle=Modulating+effects+of+matrix+metalloproteinase-3+and+-9+polymorphisms+on+aortic+stiffness+and+aortic+root+dilation+in+patients+after+tetralogy+of+Fallot+repair</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.ijcard.2010.05.046</identifier.doi>
<identifier.pmid>20541269</identifier.pmid>
<identifier.scopus>eid_2-s2.0-80052308514</identifier.scopus>
<identifier.hkuros>194873</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-80052308514&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>151</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>214</identifier.spage>
<identifier.epage>217</identifier.epage>
<identifier.isi>WOS:000294476300031</identifier.isi>
<publisher.place>Ireland</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong