Article: Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair

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TitleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
AuthorsCheung, YF1
Hong, WJ1
Chan, KW1
Wong, SJ1
KeywordsAortic stiffness
Matrix metalloproteinase polymorphism
Tetralogy of Fallot
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
CitationInternational Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2010.05.046
AbstractMatrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.
ISSN0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
DOIhttp://dx.doi.org/10.1016/j.ijcard.2010.05.046
ISI Accession Number IDWOS:000294476300031
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, YF
dc.contributor.authorHong, WJ
dc.contributor.authorChan, KW
dc.contributor.authorWong, SJ
dc.date.accessioned2011-09-23T05:51:58Z
dc.date.available2011-09-23T05:51:58Z
dc.date.issued2011
dc.description.abstractMatrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2010.05.046
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2010.05.046
dc.identifier.epage217
dc.identifier.hkuros194873
dc.identifier.isiWOS:000294476300031
dc.identifier.issn0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid20541269
dc.identifier.scopuseid_2-s2.0-80052308514
dc.identifier.spage214
dc.identifier.urihttp://hdl.handle.net/10722/139578
dc.identifier.volume151
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
dc.publisher.placeIreland
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.referencesReferences in Scopus
dc.subjectAortic stiffness
dc.subjectMatrix metalloproteinase polymorphism
dc.subjectTetralogy of Fallot
dc.titleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong