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Article: Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair

TitleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair
Authors
KeywordsAortic stiffness
Matrix metalloproteinase polymorphism
Tetralogy of Fallot
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217 How to Cite?
Abstract
Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/139578
ISSN
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorHong, WJen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorWong, SJen_HK
dc.date.accessioned2011-09-23T05:51:58Z-
dc.date.available2011-09-23T05:51:58Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 151 n. 2, p. 214-217en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139578-
dc.description.abstractMatrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C > T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p > 0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p = 0.60), heart-femoral pulse wave velocity (p = 0.63), and z score of sinotubular junction (p = 0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p = 0.005), slower heart-femoral pulse wave velocity (p = 0.03), and smaller z score of sinotubular junction (p = 0.047). Multivariate linear regression identified MMP-9 polymorphism (β = -0.31, p = 0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.relation.ispartofInternational Journal of Cardiologyen_HK
dc.subjectAortic stiffnessen_HK
dc.subjectMatrix metalloproteinase polymorphismen_HK
dc.subjectTetralogy of Falloten_HK
dc.titleModulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repairen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-5273&volume=151&issue=2&spage=214&epage=217&date=2011&atitle=Modulating+effects+of+matrix+metalloproteinase-3+and+-9+polymorphisms+on+aortic+stiffness+and+aortic+root+dilation+in+patients+after+tetralogy+of+Fallot+repair-
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2010.05.046en_HK
dc.identifier.pmid20541269en_HK
dc.identifier.scopuseid_2-s2.0-80052308514en_HK
dc.identifier.hkuros194873en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052308514&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume151en_HK
dc.identifier.issue2en_HK
dc.identifier.spage214en_HK
dc.identifier.epage217en_HK
dc.identifier.isiWOS:000294476300031-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridHong, WJ=14010481700en_HK
dc.identifier.scopusauthoridChan, KW=8587755300en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK

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