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Article: Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus

TitlePrevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus
Authors
Issue Date2010
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2010, v. 138 n. 5, p. 1101-1107 How to Cite?
AbstractBackground: Obstructive sleep apnea (OSA) is associated with disorders of glucose metabolism. Previous studies revealed a high prevalence of OSA among subjects with type 2 diabetes mellitus (DM). The aims of this study were to determine the prevalence of OSA and associated clinical factors in Chinese patients with DM. Methods: All records of the DM clinic at a teaching hospital in Hong Kong were screened between January 2007 and June 2008. Inclusion criteria for patients were Chinese, aged 18 to 75 years, with type 2 DM. Patients with unstable medical illnesses, gestational diabetes, or on renal replacement therapy were excluded. Results: Of 3,489 records screened, 1,859 subjects were eligible. A random sample of 663 (mean age, 58.2 ± 10.8; mean BMI, 26.0 ± 4.6), except six with known OSA, were invited for polysomnography (PSG). Of 165 subjects on which PSG was performed, OSA was diagnosed (apnea-hypopnea index [AHI] ≥ 5.0/h) in 89 subjects (53.9%, median Epworth Sleepiness Scale, 6 [interquartile range 3, 10]). Fifty-four (32.7%) had moderate/severe OSA (AHI ≥ 15/h). The estimated OSA prevalence in this diabetic cohort was 17.5% (24.7% in men, 10.3% in women). Regression analysis identified that AHI was associated independently with higher BMI, advanced age, male sex, and higher diastolic BP (R2 = 29.6%). The adjusted OR of requiring three or more antihypertensive drugs in moderate/severe OSA was 2.48 (95% CI, 1.05-5.87). No association between glycemic control (HbA1c) and sleep was identified. Conclusions: In conclusion, OSA is more prevalent in Chinese adults with DM than in the general population. A high index of suspicion for OSA in patients with DM is warranted, because they may not have overt daytime sleepiness. Trial registry: ClinicalTrials.gov; No.: NCT01172093; URL: www.clinicaltrials.gov. © 2010 American College of Chest Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/139459
ISSN
2014 Impact Factor: 7.483
2014 SCImago Journal Rankings: 2.636
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Boehringer Inc
Roche
GlaxoSmithKline
ResMed
Celki
Boehringer Ingelheim
Hong Kong Research Grant Council
Boehringer/Pfizer
Respironics
Funding Information:

This study was supported by the Sleep and Respiratory Fund, University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorLui, MMSen_HK
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorOng, LHYen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2011-09-23T05:50:19Z-
dc.date.available2011-09-23T05:50:19Z-
dc.date.issued2010en_HK
dc.identifier.citationChest, 2010, v. 138 n. 5, p. 1101-1107en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139459-
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is associated with disorders of glucose metabolism. Previous studies revealed a high prevalence of OSA among subjects with type 2 diabetes mellitus (DM). The aims of this study were to determine the prevalence of OSA and associated clinical factors in Chinese patients with DM. Methods: All records of the DM clinic at a teaching hospital in Hong Kong were screened between January 2007 and June 2008. Inclusion criteria for patients were Chinese, aged 18 to 75 years, with type 2 DM. Patients with unstable medical illnesses, gestational diabetes, or on renal replacement therapy were excluded. Results: Of 3,489 records screened, 1,859 subjects were eligible. A random sample of 663 (mean age, 58.2 ± 10.8; mean BMI, 26.0 ± 4.6), except six with known OSA, were invited for polysomnography (PSG). Of 165 subjects on which PSG was performed, OSA was diagnosed (apnea-hypopnea index [AHI] ≥ 5.0/h) in 89 subjects (53.9%, median Epworth Sleepiness Scale, 6 [interquartile range 3, 10]). Fifty-four (32.7%) had moderate/severe OSA (AHI ≥ 15/h). The estimated OSA prevalence in this diabetic cohort was 17.5% (24.7% in men, 10.3% in women). Regression analysis identified that AHI was associated independently with higher BMI, advanced age, male sex, and higher diastolic BP (R2 = 29.6%). The adjusted OR of requiring three or more antihypertensive drugs in moderate/severe OSA was 2.48 (95% CI, 1.05-5.87). No association between glycemic control (HbA1c) and sleep was identified. Conclusions: In conclusion, OSA is more prevalent in Chinese adults with DM than in the general population. A high index of suspicion for OSA in patients with DM is warranted, because they may not have overt daytime sleepiness. Trial registry: ClinicalTrials.gov; No.: NCT01172093; URL: www.clinicaltrials.gov. © 2010 American College of Chest Physicians.en_HK
dc.languageengen_US
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.subject.meshBlood Glucose - metabolism-
dc.subject.meshDiabetes Mellitus, Type 2 - blood - complications - epidemiology-
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshPolysomnography - methods-
dc.subject.meshSleep Apnea, Obstructive - diagnosis - epidemiology - etiology-
dc.titlePrevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, DCL:lamcl@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1378/chest.10-0596en_HK
dc.identifier.pmid20705796en_HK
dc.identifier.scopuseid_2-s2.0-78349303457en_HK
dc.identifier.hkuros194078en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349303457&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1101en_HK
dc.identifier.epage1107en_HK
dc.identifier.isiWOS:000284341700016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridLui, MMS=26027035000en_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridOng, LHY=16319950300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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