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Article: Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese

TitleRelationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese
Authors
Keywordsblood pressure
hypertension
interleukin-6
single-nucleotide polymorphism
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
Citation
American Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337 How to Cite?
AbstractBackground Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/139444
ISSN
2015 Impact Factor: 3.182
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-09-23T05:49:56Z-
dc.date.available2011-09-23T05:49:56Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337en_HK
dc.identifier.issn0895-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139444-
dc.description.abstractBackground Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Hypertensionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectblood pressureen_HK
dc.subjecthypertensionen_HK
dc.subjectinterleukin-6en_HK
dc.subjectsingle-nucleotide polymorphismen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshBlood Pressure - geneticsen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - epidemiology - geneticsen_HK
dc.subject.meshInterleukin-6 - blood - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshSex Factorsen_HK
dc.titleRelationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajh.2011.141en_HK
dc.identifier.pmid21833041-
dc.identifier.scopuseid_2-s2.0-81155159688en_HK
dc.identifier.hkuros192492en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81155159688&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1331en_HK
dc.identifier.epage1337en_HK
dc.identifier.isiWOS:000297148100015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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