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Article: Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese
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TitleRelationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese
 
AuthorsCheung, BMY1 1
Ong, KL1 3
Tso, AWK1 1
Leung, RYH1
Cherny, SS1 1
Sham, PC1 1 1
Thomas, GN2
Lam, TH1
Lam, KSL1 1
 
Keywordsblood pressure
hypertension
interleukin-6
single-nucleotide polymorphism
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
 
CitationAmerican Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2011.141
 
AbstractBackground Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd.
 
ISSN0895-7061
2012 Impact Factor: 3.665
2012 SCImago Journal Rankings: 1.268
 
DOIhttp://dx.doi.org/10.1038/ajh.2011.141
 
ISI Accession Number IDWOS:000297148100015
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorThomas, GN
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-09-23T05:49:56Z
 
dc.date.available2011-09-23T05:49:56Z
 
dc.date.issued2011
 
dc.description.abstractBackground Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2011.141
 
dc.identifier.doihttp://dx.doi.org/10.1038/ajh.2011.141
 
dc.identifier.epage1337
 
dc.identifier.hkuros192492
 
dc.identifier.isiWOS:000297148100015
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn0895-7061
2012 Impact Factor: 3.665
2012 SCImago Journal Rankings: 1.268
 
dc.identifier.issue12
 
dc.identifier.pmid21833041
 
dc.identifier.scopuseid_2-s2.0-81155159688
 
dc.identifier.spage1331
 
dc.identifier.urihttp://hdl.handle.net/10722/139444
 
dc.identifier.volume24
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdult
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshBlood Pressure - genetics
 
dc.subject.meshCross-Sectional Studies
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshHypertension - blood - epidemiology - genetics
 
dc.subject.meshInterleukin-6 - blood - genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshPrevalence
 
dc.subject.meshSex Factors
 
dc.subjectblood pressure
 
dc.subjecthypertension
 
dc.subjectinterleukin-6
 
dc.subjectsingle-nucleotide polymorphism
 
dc.titleRelationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese
 
dc.typeArticle
 
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<contributor.author>Sham, PC</contributor.author>
<contributor.author>Thomas, GN</contributor.author>
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<description.abstract>Background Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P &lt; 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. &#169; 2011 American Journal of Hypertension, Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Heart Research Institute Australia