Article: Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese
| Title | Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese |
|---|---|
| Authors | Cheung, BMY1 Ong, KL1 3 Tso, AWK1 Leung, RYH1 Cherny, SS1 Sham, PC1 Thomas, GN2 Lam, TH1 Lam, KSL1 |
| Keywords | blood pressure hypertension interleukin-6 single-nucleotide polymorphism |
| Issue Date | 2011 |
| Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html |
| Citation | American Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337 [How to Cite?] DOI: http://dx.doi.org/10.1038/ajh.2011.141 |
| Abstract | Background Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd. |
| ISSN | 0895-7061 2011 Impact Factor: 3.181 2011 SCImago Journal Rankings: 0.268 |
| DOI | http://dx.doi.org/10.1038/ajh.2011.141 |
| References | References in Scopus |
| dc.contributor.author | Cheung, BMY | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Ong, KL | ||||||
| dc.contributor.author | Tso, AWK | ||||||
| dc.contributor.author | Leung, RYH | ||||||
| dc.contributor.author | Cherny, SS | ||||||
| dc.contributor.author | Sham, PC | ||||||
| dc.contributor.author | Thomas, GN | ||||||
| dc.contributor.author | Lam, TH | ||||||
| dc.contributor.author | Lam, KSL | ||||||
| dc.date.accessioned | 2011-09-23T05:49:56Z | ||||||
| dc.date.available | 2011-09-23T05:49:56Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Background Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs. Methods Plasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS)-2 in 2000-2004 and three tagging single-nucleotide polymorphisms (SNPs) in the IL6 gene were genotyped. Among subjects normotensive in CRISPS-2 (baseline), 515 subjects were followed-up in CRISPS-3 in 2005-2008 and 100 of them had developed hypertension. Results At baseline, plasma IL6 correlated with systolic blood pressure (SBP) (r = 0.128, P < 0.001). Hypertensive subjects had significantly higher plasma IL6 after adjusting for age and sex (geometric mean (95% confidence interval (CI) = 0.60 (0.54-0.65) vs. 0.47 (0.44-0.50) ng/l, P = 0.021). In multiple logistic regression, higher plasma IL6 was associated with hypertension in women (P = 0.009), but not in men. The minor G allele of SNP rs1800796 was associated with lower plasma IL6 (geometric mean (95% CI) = 0.46 (0.41-0.51) ng/l for CG and 0.49 (0.39-0.62) ng/l for GG vs. 0.53 (0.50-0.57) ng/l for CC, P = 0.005). However, this SNP was not associated with hypertension or blood pressure at baseline. Among subjects normotensive in CRISPS-2, plasma IL6 was not associated with the development of hypertension in CRISPS-3. Conclusion The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension. © 2011 American Journal of Hypertension, Ltd. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | American Journal Of Hypertension, 2011, v. 24 n. 12, p. 1331-1337 [How to Cite?] DOI: http://dx.doi.org/10.1038/ajh.2011.141 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/ajh.2011.141 | ||||||
| dc.identifier.epage | 1337 | ||||||
| dc.identifier.hkuros | 192492 | ||||||
| dc.identifier.isi | WOS:000297148100015
Funding Information: This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation. | ||||||
| dc.identifier.issn | 0895-7061 2011 Impact Factor: 3.181 2011 SCImago Journal Rankings: 0.268 | ||||||
| dc.identifier.issue | 12 | ||||||
| dc.identifier.pmid | 21833041 | ||||||
| dc.identifier.scopus | eid_2-s2.0-81155159688 | ||||||
| dc.identifier.spage | 1331 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/139444 | ||||||
| dc.identifier.volume | 24 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | American Journal of Hypertension | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||
| dc.subject.mesh | Adult | ||||||
| dc.subject.mesh | Asian Continental Ancestry Group - genetics | ||||||
| dc.subject.mesh | Blood Pressure - genetics | ||||||
| dc.subject.mesh | Cross-Sectional Studies | ||||||
| dc.subject.mesh | Female | ||||||
| dc.subject.mesh | Hong Kong - epidemiology | ||||||
| dc.subject.mesh | Humans | ||||||
| dc.subject.mesh | Hypertension - blood - epidemiology - genetics | ||||||
| dc.subject.mesh | Interleukin-6 - blood - genetics | ||||||
| dc.subject.mesh | Male | ||||||
| dc.subject.mesh | Middle Aged | ||||||
| dc.subject.mesh | Polymorphism, Single Nucleotide | ||||||
| dc.subject.mesh | Prevalence | ||||||
| dc.subject.mesh | Sex Factors | ||||||
| dc.subject | blood pressure | ||||||
| dc.subject | hypertension | ||||||
| dc.subject | interleukin-6 | ||||||
| dc.subject | single-nucleotide polymorphism | ||||||
| dc.title | Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong chinese | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- University of Birmingham
- Heart Research Institute Australia