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Article: Possible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and alzheimer's disease

TitlePossible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and alzheimer's disease
Authors
KeywordsAging
Alzheimer's disease
diffusion tensor imaging
fiber tracking
retrogenesis
white matter integrity
Issue Date2011
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2011, v. 26 n. 1, p. 47-58 How to Cite?
AbstractRetrogenesis refers to the phenomenon by which degenerative processes in aging reverse the sequence of acquisition in development. Although there has been some evidence for brain retrogenesis in abnormal aging, e.g., Alzheimer's disease (AD), it has not been explicitly addressed in the normal aging. Using diffusion tensor imaging and tractography, we explored the effects of normal and abnormal aging on the integrity of white matter (WM) in fifty participants, including 18 AD patients, 17 normal elderly, and 15 normal young adults. Compared with young adults, the traditional voxel-based analysis, and the quantitative fiber tracking methods revealed lower fractional anisotrophy (FA) for both normal elderly and AD patients, indicating WM disintegrity in the anterior part of the brain with developmentally late-myelinating fiber bundles. Furthermore, AD patients showed lower FA in the posterior part of the brain with relatively early-myelinating fiber bundles. Additional analysis on axial diffusion and radial diffusion measures suggest that demyelination may be the main mechanism underlying the observed microstructural impairments. Consistent with a proposal of retrogenesis, our results demonstrate an anteroposterior pattern of white matter disintegrity in both normal aging and AD, with the pattern being more salient in the latter than in the former. © 2011-IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139141
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
Funding AgencyGrant Number
Stanley Ho Alumni Challenge Fund20810027
20731020
Funding Information:

This study was supported by Stanley Ho Alumni Challenge Fund (20810027 & 20731020) awarded to Professor RTF Cheung.

References

 

DC FieldValueLanguage
dc.contributor.authorGao, Jen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChu, LWen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorQiu, Den_HK
dc.contributor.authorFung, Gen_HK
dc.contributor.authorCheung, Cen_HK
dc.date.accessioned2011-09-23T05:45:47Z-
dc.date.available2011-09-23T05:45:47Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Alzheimer's Disease, 2011, v. 26 n. 1, p. 47-58en_HK
dc.identifier.issn1387-2877en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139141-
dc.description.abstractRetrogenesis refers to the phenomenon by which degenerative processes in aging reverse the sequence of acquisition in development. Although there has been some evidence for brain retrogenesis in abnormal aging, e.g., Alzheimer's disease (AD), it has not been explicitly addressed in the normal aging. Using diffusion tensor imaging and tractography, we explored the effects of normal and abnormal aging on the integrity of white matter (WM) in fifty participants, including 18 AD patients, 17 normal elderly, and 15 normal young adults. Compared with young adults, the traditional voxel-based analysis, and the quantitative fiber tracking methods revealed lower fractional anisotrophy (FA) for both normal elderly and AD patients, indicating WM disintegrity in the anterior part of the brain with developmentally late-myelinating fiber bundles. Furthermore, AD patients showed lower FA in the posterior part of the brain with relatively early-myelinating fiber bundles. Additional analysis on axial diffusion and radial diffusion measures suggest that demyelination may be the main mechanism underlying the observed microstructural impairments. Consistent with a proposal of retrogenesis, our results demonstrate an anteroposterior pattern of white matter disintegrity in both normal aging and AD, with the pattern being more salient in the latter than in the former. © 2011-IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_HK
dc.relation.ispartofJournal of Alzheimer's Diseaseen_HK
dc.subjectAgingen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectdiffusion tensor imagingen_HK
dc.subjectfiber trackingen_HK
dc.subjectretrogenesisen_HK
dc.subjectwhite matter integrityen_HK
dc.subject.meshAging - pathology-
dc.subject.meshAlzheimer Disease - pathology-
dc.subject.meshAnisotropy-
dc.subject.meshBrain - pathology-
dc.subject.meshNerve Fibers, Myelinated - pathology-
dc.titlePossible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and alzheimer's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_HK
dc.identifier.emailLee, TMC: tmclee@hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/JAD-2011-101788en_HK
dc.identifier.pmid21558648-
dc.identifier.scopuseid_2-s2.0-80052840455en_HK
dc.identifier.hkuros192691en_US
dc.identifier.hkuros219142-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052840455&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue1en_HK
dc.identifier.spage47en_HK
dc.identifier.epage58en_HK
dc.identifier.eissn1875-8908-
dc.identifier.isiWOS:000294326100006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridGao, J=37026045300en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridZhang, JX=35239018400en_HK
dc.identifier.scopusauthoridQiu, D=12778150600en_HK
dc.identifier.scopusauthoridFung, G=36552327800en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK

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