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Article: Efficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in alzheimer's disease patients and cognitively normal older adults at 3.0 tesla MR imaging

TitleEfficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in alzheimer's disease patients and cognitively normal older adults at 3.0 tesla MR imaging
Authors
Keywords3.0 Tesla
Alzheimer's disease
ANALYZE 7.0 software
cognitively normal older adults
manual hippocampal volumetry
MRI
SPM5 software with DARTEL registration
VBM
Issue Date2011
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2011, v. 23 n. 4, p. 655-664 How to Cite?
AbstractQuantitative MRI of the hippocampus has been increasingly employed as a biomarker in Alzheimer's disease (AD). We compare voxel-based morphometry (VBM) standard and DARTEL registration with manual hippocampal volumetry in AD patients and cognitively normal older adults. Participants were 20 cognitively normal elderly subjects and 19 AD patients who met the criteria of probable AD according to NINCDS-ADRDA. Bilateral manual hippocampal volumetry was conducted alongside VBM of hippocampal regions-of-interest (ROIs) generated with standard and DARTEL registration using hippocampal masks and total intracranial volume normalization. All normalized hippocampal measurements showed significant reduction (20-30%; p < 0.001) in AD compared to controls. Logistic regression analysis also showed significant effects (odds ratios ranged from 88.2% to 94.0%) of all normalized measurements in predicting AD incidence after adjusting for age, gender, and education. The overall prediction accuracies of manual RH and LH volumes, standard RH-ROI and LH-ROI VBM, DARTEL RH-ROI, and LH-ROI VBM were 87.2%, 84.6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. As imaging biomarkers, VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults. © 2011 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139140
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorYau, KKWen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorChu, LWen_HK
dc.date.accessioned2011-09-23T05:45:44Z-
dc.date.available2011-09-23T05:45:44Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Alzheimer's Disease, 2011, v. 23 n. 4, p. 655-664en_HK
dc.identifier.issn1387-2877en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139140-
dc.description.abstractQuantitative MRI of the hippocampus has been increasingly employed as a biomarker in Alzheimer's disease (AD). We compare voxel-based morphometry (VBM) standard and DARTEL registration with manual hippocampal volumetry in AD patients and cognitively normal older adults. Participants were 20 cognitively normal elderly subjects and 19 AD patients who met the criteria of probable AD according to NINCDS-ADRDA. Bilateral manual hippocampal volumetry was conducted alongside VBM of hippocampal regions-of-interest (ROIs) generated with standard and DARTEL registration using hippocampal masks and total intracranial volume normalization. All normalized hippocampal measurements showed significant reduction (20-30%; p < 0.001) in AD compared to controls. Logistic regression analysis also showed significant effects (odds ratios ranged from 88.2% to 94.0%) of all normalized measurements in predicting AD incidence after adjusting for age, gender, and education. The overall prediction accuracies of manual RH and LH volumes, standard RH-ROI and LH-ROI VBM, DARTEL RH-ROI, and LH-ROI VBM were 87.2%, 84.6%, 87.2%, 76.9%, 87.2%, and 87.2%, respectively. As imaging biomarkers, VBM with DARTEL and standard registration have similarly high efficacies as manual hippocampal volumetry in discriminating AD from cognitively normal elderly adults. © 2011 - IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_HK
dc.relation.ispartofJournal of Alzheimer's Diseaseen_HK
dc.subject3.0 Teslaen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectANALYZE 7.0 softwareen_HK
dc.subjectcognitively normal older adultsen_HK
dc.subjectmanual hippocampal volumetryen_HK
dc.subjectMRIen_HK
dc.subjectSPM5 software with DARTEL registrationen_HK
dc.subjectVBMen_HK
dc.titleEfficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in alzheimer's disease patients and cognitively normal older adults at 3.0 tesla MR imagingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1387-2877&volume=23&issue=4&spage=655&epage=664&date=2011&atitle=Efficacy+of+voxel-based+morphometry+with+DARTEL+and+standard+registration+as+imaging+biomarkers+in+Alzheimer%27s+patients+and+cognitively+normal+older+adults+at+3.0+Tesla+MR+Imaging.-
dc.identifier.emailMak, HKF:makkf@hkucc.hku.hken_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/JAD-2010-101659en_HK
dc.identifier.pmid21157022-
dc.identifier.scopuseid_2-s2.0-79953284028en_HK
dc.identifier.hkuros192689en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953284028&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue4en_HK
dc.identifier.spage655en_HK
dc.identifier.epage664en_HK
dc.identifier.eissn1875-8908-
dc.identifier.isiWOS:000288989600007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridZhang, Z=37099181100en_HK
dc.identifier.scopusauthoridYau, KKW=7101941425en_HK
dc.identifier.scopusauthoridZhang, L=37099212900en_HK
dc.identifier.scopusauthoridChan, Q=6602497305en_HK
dc.identifier.scopusauthoridChu, LW=7202236665en_HK

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