File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
  • Basic View
  • Metadata View
  • XML View
TitleAn SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
 
AuthorsZhang, G4
Chen, X4
Chan, L1 3
Zhang, M4
Zhu, B2
Wang, L4
Zhu, X4
Zhang, J4
Zhou, B4
Wang, J1
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html
 
CitationScientific Reports, 2011, v. 1, article no. 20 [How to Cite?]
DOI: http://dx.doi.org/10.1038/srep00020
 
AbstractRecent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.
 
ISSN2045-2322
2013 Impact Factor: 5.078
2013 SCImago Journal Rankings: 1.857
 
DOIhttp://dx.doi.org/10.1038/srep00020
 
PubMed Central IDPMC3216508
 
ISI Accession Number IDWOS:000296046600002
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
2008ZX10003-012
National Science Foundation of China30872258
Research Grants Council778609M
N_HKU752/10
Research Fund for the Control of Infectious Diseases of Hong Kong10091262
Funding Information:

We thank Yan Zhang, Wanling Yang and Yu Lung Lau of the University of Hong Kong for assistance in genotyping samples and critical comments on the manuscript. Financial support was provided by Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005,2008ZX10003-012) and National Science Foundation (30872258) of China, and Research Grants Council (778609M, N_HKU752/10) and Research Fund for the Control of Infectious Diseases (10091262) of Hong Kong.

 
ReferencesReferences in Scopus
 
GrantsA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
 
DC FieldValue
dc.contributor.authorZhang, G
 
dc.contributor.authorChen, X
 
dc.contributor.authorChan, L
 
dc.contributor.authorZhang, M
 
dc.contributor.authorZhu, B
 
dc.contributor.authorWang, L
 
dc.contributor.authorZhu, X
 
dc.contributor.authorZhang, J
 
dc.contributor.authorZhou, B
 
dc.contributor.authorWang, J
 
dc.date.accessioned2011-09-23T05:43:05Z
 
dc.date.available2011-09-23T05:43:05Z
 
dc.date.issued2011
 
dc.description.abstractRecent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationScientific Reports, 2011, v. 1, article no. 20 [How to Cite?]
DOI: http://dx.doi.org/10.1038/srep00020
 
dc.identifier.doihttp://dx.doi.org/10.1038/srep00020
 
dc.identifier.epage20
 
dc.identifier.hkuros192077
 
dc.identifier.isiWOS:000296046600002
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
2008ZX10003-012
National Science Foundation of China30872258
Research Grants Council778609M
N_HKU752/10
Research Fund for the Control of Infectious Diseases of Hong Kong10091262
Funding Information:

We thank Yan Zhang, Wanling Yang and Yu Lung Lau of the University of Hong Kong for assistance in genotyping samples and critical comments on the manuscript. Financial support was provided by Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005,2008ZX10003-012) and National Science Foundation (30872258) of China, and Research Grants Council (778609M, N_HKU752/10) and Research Fund for the Control of Infectious Diseases (10091262) of Hong Kong.

 
dc.identifier.issn2045-2322
2013 Impact Factor: 5.078
2013 SCImago Journal Rankings: 1.857
 
dc.identifier.pmcidPMC3216508
 
dc.identifier.pmid22355539
 
dc.identifier.scopuseid_2-s2.0-84860115415
 
dc.identifier.spage20
 
dc.identifier.urihttp://hdl.handle.net/10722/138954
 
dc.identifier.volume1
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofScientific Reports
 
dc.relation.projectA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
 
dc.relation.referencesReferences in Scopus
 
dc.titleAn SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Zhang, G</contributor.author>
<contributor.author>Chen, X</contributor.author>
<contributor.author>Chan, L</contributor.author>
<contributor.author>Zhang, M</contributor.author>
<contributor.author>Zhu, B</contributor.author>
<contributor.author>Wang, L</contributor.author>
<contributor.author>Zhu, X</contributor.author>
<contributor.author>Zhang, J</contributor.author>
<contributor.author>Zhou, B</contributor.author>
<contributor.author>Wang, J</contributor.author>
<date.accessioned>2011-09-23T05:43:05Z</date.accessioned>
<date.available>2011-09-23T05:43:05Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Scientific Reports, 2011, v. 1, article no. 20</identifier.citation>
<identifier.issn>2045-2322</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/138954</identifier.uri>
<description.abstract>Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/srep/index.html</publisher>
<relation.ispartof>Scientific Reports</relation.ispartof>
<title>An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1038/srep00020</identifier.doi>
<identifier.pmid>22355539</identifier.pmid>
<identifier.pmcid>PMC3216508</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-84860115415</identifier.scopus>
<identifier.hkuros>192077</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84860115415&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>1</identifier.volume>
<identifier.spage>20</identifier.spage>
<identifier.epage>20</identifier.epage>
<identifier.isi>WOS:000296046600002</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<relation.project>A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus</relation.project>
<bitstream.url>http://hub.hku.hk/bitstream/10722/138954/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Guangdong Medical College
  3. Carleton College, USA
  4. Shenzhen People's Hospital