Article: An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
| Title | An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Zhang, G4 Chen, X4 Chan, L1 3 Zhang, M4 Zhu, B2 Wang, L4 Zhu, X4 Zhang, J4 Zhou, B4 Wang, J1 | ||||||||||
| Issue Date | 2011 | ||||||||||
| Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html | ||||||||||
| Citation | Scientific Reports, 2011, v. 1, article no. 20 [How to Cite?] DOI: http://dx.doi.org/10.1038/srep00020 | ||||||||||
| Abstract | Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations. | ||||||||||
| ISSN | 2045-2322 | ||||||||||
| DOI | http://dx.doi.org/10.1038/srep00020 | ||||||||||
| ISI Accession Number ID | WOS:000296046600002
Funding Information: We thank Yan Zhang, Wanling Yang and Yu Lung Lau of the University of Hong Kong for assistance in genotyping samples and critical comments on the manuscript. Financial support was provided by Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005,2008ZX10003-012) and National Science Foundation (30872258) of China, and Research Grants Council (778609M, N_HKU752/10) and Research Fund for the Control of Infectious Diseases (10091262) of Hong Kong. | ||||||||||
| PubMed Central ID | PMC3216508 | ||||||||||
| References | References in Scopus | ||||||||||
| Grants | A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus |
| dc.contributor.author | Zhang, G | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Chen, X | ||||||||||
| dc.contributor.author | Chan, L | ||||||||||
| dc.contributor.author | Zhang, M | ||||||||||
| dc.contributor.author | Zhu, B | ||||||||||
| dc.contributor.author | Wang, L | ||||||||||
| dc.contributor.author | Zhu, X | ||||||||||
| dc.contributor.author | Zhang, J | ||||||||||
| dc.contributor.author | Zhou, B | ||||||||||
| dc.contributor.author | Wang, J | ||||||||||
| dc.date.accessioned | 2011-09-23T05:43:05Z | ||||||||||
| dc.date.available | 2011-09-23T05:43:05Z | ||||||||||
| dc.date.issued | 2011 | ||||||||||
| dc.description.abstract | Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations. | ||||||||||
| dc.description.grant | A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus | ||||||||||
| dc.description.grantcode | 103716 | ||||||||||
| dc.description.nature | link_to_OA_fulltext | ||||||||||
| dc.identifier.citation | Scientific Reports, 2011, v. 1, article no. 20 [How to Cite?] DOI: http://dx.doi.org/10.1038/srep00020 | ||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/srep00020 | ||||||||||
| dc.identifier.epage | 20 | ||||||||||
| dc.identifier.hkuros | 192077 | ||||||||||
| dc.identifier.isi | WOS:000296046600002
Funding Information: We thank Yan Zhang, Wanling Yang and Yu Lung Lau of the University of Hong Kong for assistance in genotyping samples and critical comments on the manuscript. Financial support was provided by Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005,2008ZX10003-012) and National Science Foundation (30872258) of China, and Research Grants Council (778609M, N_HKU752/10) and Research Fund for the Control of Infectious Diseases (10091262) of Hong Kong. | ||||||||||
| dc.identifier.issn | 2045-2322 | ||||||||||
| dc.identifier.pmcid | PMC3216508 | ||||||||||
| dc.identifier.pmid | 22355539 | ||||||||||
| dc.identifier.scopus | eid_2-s2.0-84860115415 | ||||||||||
| dc.identifier.spage | 20 | ||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/138954 | ||||||||||
| dc.identifier.volume | 1 | ||||||||||
| dc.language | eng | ||||||||||
| dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html | ||||||||||
| dc.publisher.place | United Kingdom | ||||||||||
| dc.relation.ispartof | Scientific Reports | ||||||||||
| dc.relation.references | References in Scopus | ||||||||||
| dc.title | An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese | ||||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- Guangdong Medical College
- Carleton College, USA
- Shenzhen People's Hospital