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Article: An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese

TitleAn SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
Authors
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2011, v. 1, article no. 20 How to Cite?
Abstract
Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.
Persistent Identifierhttp://hdl.handle.net/10722/138954
ISSN
2013 Impact Factor: 5.078
2013 SCImago Journal Rankings: 1.857
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
2008ZX10003-012
National Science Foundation of China30872258
Research Grants Council778609M
N_HKU752/10
Research Fund for the Control of Infectious Diseases of Hong Kong10091262
Funding Information:

We thank Yan Zhang, Wanling Yang and Yu Lung Lau of the University of Hong Kong for assistance in genotyping samples and critical comments on the manuscript. Financial support was provided by Eleven-Fifth Mega-Scientific Project on "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005,2008ZX10003-012) and National Science Foundation (30872258) of China, and Research Grants Council (778609M, N_HKU752/10) and Research Fund for the Control of Infectious Diseases (10091262) of Hong Kong.

References
Grants

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Guangdong Medical College
  3. Carleton College, USA
  4. Shenzhen People's Hospital
DC FieldValueLanguage
dc.contributor.authorZhang, Gen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorChan, Len_HK
dc.contributor.authorZhang, Men_HK
dc.contributor.authorZhu, Ben_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorZhu, Xen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorZhou, Ben_HK
dc.contributor.authorWang, Jen_HK
dc.date.accessioned2011-09-23T05:43:05Z-
dc.date.available2011-09-23T05:43:05Z-
dc.date.issued2011en_HK
dc.identifier.citationScientific Reports, 2011, v. 1, article no. 20en_HK
dc.identifier.issn2045-2322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/138954-
dc.description.abstractRecent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reportsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAn SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, J:junwen@hkucc.hku.hken_HK
dc.identifier.authorityWang, J=rp00280en_HK
dc.description.naturePublished_or_final_version-
dc.identifier.doi10.1038/srep00020en_HK
dc.identifier.pmid22355539-
dc.identifier.pmcidPMC3216508-
dc.identifier.scopuseid_2-s2.0-84860115415en_HK
dc.identifier.hkuros192077en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860115415&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.spage20en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000296046600002-
dc.publisher.placeUnited Kingdom-
dc.relation.projectA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus-
dc.identifier.scopusauthoridZhang, G=55085965600en_HK
dc.identifier.scopusauthoridChen, X=8710357400en_HK
dc.identifier.scopusauthoridChan, L=55194577900en_HK
dc.identifier.scopusauthoridZhang, M=7601556521en_HK
dc.identifier.scopusauthoridZhu, B=37008126400en_HK
dc.identifier.scopusauthoridWang, L=37008108500en_HK
dc.identifier.scopusauthoridZhu, X=26668175100en_HK
dc.identifier.scopusauthoridZhang, J=54998245300en_HK
dc.identifier.scopusauthoridZhou, B=7401906727en_HK
dc.identifier.scopusauthoridWang, J=8950599500en_HK

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