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Article: Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model

TitleEffect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model
Authors
Issue Date2011
PublisherSpringer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=238
Citation
Clinical And Experimental Medicine, 2011, v. 11 n. 1, p. 25-32 How to Cite?
AbstractPrimary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. After 6 weeks of MSC infusion, serum aminotransferase and autoimmune antibodies declined, and histological examination by hematoxylin and eosin staining showed significant amelioration of monocytes infiltration around bile ducts of mice treated with BM-MSC. Interestingly, allogeneic BM-MSC transplantation markedly increased CD4+Foxp3+ regulatory T cells in peripheral blood as well as in lymph nodes when analyzed by flow cytometry. Further examination showed serum TGF-β1 increased but IFN-γ decreased significantly in PBC mice treated with MSC, while with no obvious change in IL-10 expression. Our results for the first time suggested that BM-MSC transplantation could regulate systemic immune response and enhance recovery in liver inflammation of PBC mice, raising the possibility for clinical application of allogeneic MSC in treatment of early-stage PBC patients. © 2010 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/137631
ISSN
2014 Impact Factor: 2.959
ISI Accession Number ID
Funding AgencyGrant Number
Jiangsu Province 135 Talent FoundationRC2007004
Funding Information:

This work was supported by a grant from the Jiangsu Province 135 Talent Foundation (RC2007004).

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Den_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorLiang, Jen_HK
dc.contributor.authorGu, Zen_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorHuang, Jen_HK
dc.contributor.authorLin, Jen_HK
dc.contributor.authorHou, Yen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorSun, Len_HK
dc.date.accessioned2011-08-26T14:29:47Z-
dc.date.available2011-08-26T14:29:47Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical And Experimental Medicine, 2011, v. 11 n. 1, p. 25-32en_HK
dc.identifier.issn1591-8890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137631-
dc.description.abstractPrimary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. After 6 weeks of MSC infusion, serum aminotransferase and autoimmune antibodies declined, and histological examination by hematoxylin and eosin staining showed significant amelioration of monocytes infiltration around bile ducts of mice treated with BM-MSC. Interestingly, allogeneic BM-MSC transplantation markedly increased CD4+Foxp3+ regulatory T cells in peripheral blood as well as in lymph nodes when analyzed by flow cytometry. Further examination showed serum TGF-β1 increased but IFN-γ decreased significantly in PBC mice treated with MSC, while with no obvious change in IL-10 expression. Our results for the first time suggested that BM-MSC transplantation could regulate systemic immune response and enhance recovery in liver inflammation of PBC mice, raising the possibility for clinical application of allogeneic MSC in treatment of early-stage PBC patients. © 2010 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=238en_HK
dc.relation.ispartofClinical and Experimental Medicineen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntigens, CD4 - analysisen_HK
dc.subject.meshAutoantibodies - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshForkhead Transcription Factors - analysisen_HK
dc.subject.meshHistocytochemistryen_HK
dc.subject.meshInterleukin-10 - biosynthesisen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshLiver Cirrhosis, Biliary - chemically induced - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesenchymal Stem Cell Transplantationen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshPoly I-C - toxicityen_HK
dc.subject.meshT-Lymphocytes, Regulatory - chemistry - immunologyen_HK
dc.subject.meshTransaminases - blooden_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleEffect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse modelen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10238-010-0105-6en_HK
dc.identifier.pmid20661620en_HK
dc.identifier.scopuseid_2-s2.0-79951949990en_HK
dc.identifier.hkuros191303en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951949990&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage32en_HK
dc.identifier.isiWOS:000286982400004-
dc.publisher.placeItalyen_HK
dc.identifier.citeulike7774631-

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