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Article: Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population

TitleChemopreventive effect of PSP through targeting of prostate cancer stem cell-like population
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 5 How to Cite?
AbstractRecent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer. © 2011 Luk et al.
Persistent Identifierhttp://hdl.handle.net/10722/137621
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Vice Chancellor Research Fellowship
Funding Information:

Vice Chancellor Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorLuk, SUen_HK
dc.contributor.authorLee, TKWen_HK
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorLee, DTWen_HK
dc.contributor.authorChiu, YTen_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorChan, FLen_HK
dc.contributor.authorLing, MTen_HK
dc.date.accessioned2011-08-26T14:29:31Z-
dc.date.available2011-08-26T14:29:31Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 5en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137621-
dc.description.abstractRecent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer. © 2011 Luk et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChemoprevention - methods-
dc.subject.meshDrug Delivery Systems - methods-
dc.subject.meshNeoplastic Stem Cells - drug effects-
dc.subject.meshProstatic Neoplasms - drug therapy - pathology - prevention and control-
dc.subject.meshProteoglycans - pharmacology - therapeutic use-
dc.titleChemopreventive effect of PSP through targeting of prostate cancer stem cell-like populationen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, TKW:tkwlee@hkucc.hku.hken_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.authorityLee, TKW=rp00447en_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0019804en_HK
dc.identifier.pmid21603625-
dc.identifier.pmcidPMC3095629-
dc.identifier.scopuseid_2-s2.0-79956100438en_HK
dc.identifier.hkuros189782en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956100438&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spagee19804en_US
dc.identifier.epagee19804en_US
dc.identifier.isiWOS:000290656300028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuk, SU=36981977600en_HK
dc.identifier.scopusauthoridLee, TKW=7501439435en_HK
dc.identifier.scopusauthoridLiu, J=53363896000en_HK
dc.identifier.scopusauthoridLee, DTW=15747521900en_HK
dc.identifier.scopusauthoridChiu, YT=23975797700en_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridChan, FL=36591823900en_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK

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