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Article: Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

TitlePlasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
Authors
Issue Date2011
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577 How to Cite?
AbstractObjective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/137411
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-08-26T14:24:31Z-
dc.date.available2011-08-26T14:24:31Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137411-
dc.description.abstractObjective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology.en_HK
dc.languageengen_US
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.subject.meshAdrenomedullin-
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshBiological Markers-
dc.subject.meshC-Reactive Protein-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshFemale-
dc.subject.meshFibrinogen-
dc.subject.meshGene Frequency-
dc.subject.meshGenotype-
dc.subject.meshHaplotypes-
dc.subject.meshHong Kong-
dc.subject.meshHumans-
dc.subject.meshInterleukin-6-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMultivariate Analysis-
dc.subject.meshPolymorphism-
dc.subject.meshSingle Nucleotide-
dc.subject.meshRisk Factors-
dc.subject.meshSex Factors-
dc.titlePlasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin geneen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailOng, KL: okl2000@hku.hken_HK
dc.identifier.emailTso, AWK: awktso@hku.hken_HK
dc.identifier.emailLeung, YH: yhleung@hkucc.hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1530/EJE-11-0513en_HK
dc.identifier.pmid21798961-
dc.identifier.scopuseid_2-s2.0-80053556670en_HK
dc.identifier.hkuros190895en_US
dc.identifier.hkuros213339-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053556670&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume165en_HK
dc.identifier.issue4en_HK
dc.identifier.spage571en_HK
dc.identifier.epage577en_HK
dc.identifier.isiWOS:000295958700011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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