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Article: Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
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TitlePlasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
 
AuthorsCheung, BMY1
Ong, KL1
Tso, AWK1
Leung, RYH1
Cherny, SS1
Sham, PC1
Lam, TH1
Lam, KSL1
 
Issue Date2011
 
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
 
CitationEuropean Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577 [How to Cite?]
DOI: http://dx.doi.org/10.1530/EJE-11-0513
 
AbstractObjective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology.
 
ISSN0804-4643
2012 Impact Factor: 3.136
2012 SCImago Journal Rankings: 1.223
 
DOIhttp://dx.doi.org/10.1530/EJE-11-0513
 
ISI Accession Number IDWOS:000295958700011
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorOng, KL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-08-26T14:24:31Z
 
dc.date.available2011-08-26T14:24:31Z
 
dc.date.issued2011
 
dc.description.abstractObjective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationEuropean Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577 [How to Cite?]
DOI: http://dx.doi.org/10.1530/EJE-11-0513
 
dc.identifier.doihttp://dx.doi.org/10.1530/EJE-11-0513
 
dc.identifier.epage577
 
dc.identifier.hkuros190895
 
dc.identifier.hkuros213339
 
dc.identifier.isiWOS:000295958700011
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn0804-4643
2012 Impact Factor: 3.136
2012 SCImago Journal Rankings: 1.223
 
dc.identifier.issue4
 
dc.identifier.pmid21798961
 
dc.identifier.scopuseid_2-s2.0-80053556670
 
dc.identifier.spage571
 
dc.identifier.urihttp://hdl.handle.net/10722/137411
 
dc.identifier.volume165
 
dc.languageeng
 
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Journal of Endocrinology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdrenomedullin
 
dc.subject.meshAdult
 
dc.subject.meshAge Factors
 
dc.subject.meshAged
 
dc.subject.meshBiological Markers
 
dc.subject.meshC-Reactive Protein
 
dc.subject.meshCardiovascular Diseases
 
dc.subject.meshFemale
 
dc.subject.meshFibrinogen
 
dc.subject.meshGene Frequency
 
dc.subject.meshGenotype
 
dc.subject.meshHaplotypes
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshInterleukin-6
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMultivariate Analysis
 
dc.subject.meshPolymorphism
 
dc.subject.meshSingle Nucleotide
 
dc.subject.meshRisk Factors
 
dc.subject.meshSex Factors
 
dc.titlePlasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
 
dc.typeArticle
 
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<contributor.author>Leung, RYH</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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Author Affiliations
  1. The University of Hong Kong