Article: Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
| Title | Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Cheung, BMY1 Ong, KL1 Tso, AWK1 Leung, RYH1 Cherny, SS1 Sham, PC1 Lam, TH1 Lam, KSL1 | ||||||
| Issue Date | 2011 | ||||||
| Publisher | BioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/ | ||||||
| Citation | European Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577 [How to Cite?] DOI: http://dx.doi.org/10.1530/EJE-11-0513 | ||||||
| Abstract | Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology. | ||||||
| ISSN | 0804-4643 2011 Impact Factor: 3.423 2011 SCImago Journal Rankings: 0.309 | ||||||
| DOI | http://dx.doi.org/10.1530/EJE-11-0513 | ||||||
| ISI Accession Number ID | WOS:000295958700011
Funding Information: This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation. | ||||||
| References | References in Scopus |
| dc.contributor.author | Cheung, BMY | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Ong, KL | ||||||
| dc.contributor.author | Tso, AWK | ||||||
| dc.contributor.author | Leung, RYH | ||||||
| dc.contributor.author | Cherny, SS | ||||||
| dc.contributor.author | Sham, PC | ||||||
| dc.contributor.author | Lam, TH | ||||||
| dc.contributor.author | Lam, KSL | ||||||
| dc.date.accessioned | 2011-08-26T14:24:31Z | ||||||
| dc.date.available | 2011-08-26T14:24:31Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (β-0.116, P=0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (P=0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (β=-0.115, P=0.011). Haplotype analysis revealed a similar significant association with plasma ADM (P=0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (P=0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction. © 2011 European Society of Endocrinology. | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.identifier.citation | European Journal of Endocrinology, 2011, v. 165 n. 4, p. 571-577 [How to Cite?] DOI: http://dx.doi.org/10.1530/EJE-11-0513 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1530/EJE-11-0513 | ||||||
| dc.identifier.epage | 577 | ||||||
| dc.identifier.hkuros | 190895 | ||||||
| dc.identifier.hkuros | 213339 | ||||||
| dc.identifier.isi | WOS:000295958700011
Funding Information: This study was funded by Hong Kong Research Grants Council grants (HKU7229/01M and HKU7626/07M) and the Sun Chieh Yeh Heart Foundation. | ||||||
| dc.identifier.issn | 0804-4643 2011 Impact Factor: 3.423 2011 SCImago Journal Rankings: 0.309 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.pmid | 21798961 | ||||||
| dc.identifier.scopus | eid_2-s2.0-80053556670 | ||||||
| dc.identifier.spage | 571 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/137411 | ||||||
| dc.identifier.volume | 165 | ||||||
| dc.language | eng | ||||||
| dc.publisher | BioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/ | ||||||
| dc.publisher.place | United Kingdom | ||||||
| dc.relation.ispartof | European Journal of Endocrinology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Adrenomedullin | ||||||
| dc.subject.mesh | Adult | ||||||
| dc.subject.mesh | Age Factors | ||||||
| dc.subject.mesh | Aged | ||||||
| dc.subject.mesh | Biological Markers | ||||||
| dc.subject.mesh | C-Reactive Protein | ||||||
| dc.subject.mesh | Cardiovascular Diseases | ||||||
| dc.subject.mesh | Female | ||||||
| dc.subject.mesh | Fibrinogen | ||||||
| dc.subject.mesh | Gene Frequency | ||||||
| dc.subject.mesh | Genotype | ||||||
| dc.subject.mesh | Haplotypes | ||||||
| dc.subject.mesh | Hong Kong | ||||||
| dc.subject.mesh | Humans | ||||||
| dc.subject.mesh | Interleukin-6 | ||||||
| dc.subject.mesh | Male | ||||||
| dc.subject.mesh | Middle Aged | ||||||
| dc.subject.mesh | Multivariate Analysis | ||||||
| dc.subject.mesh | Polymorphism | ||||||
| dc.subject.mesh | Single Nucleotide | ||||||
| dc.subject.mesh | Risk Factors | ||||||
| dc.subject.mesh | Sex Factors | ||||||
| dc.title | Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong