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Article: Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: A 10-year prospective study
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TitlePlasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: A 10-year prospective study
 
AuthorsChen, C2 1
Tso, AWK2 1
Cheung, BMY2 1
Law, LSC2
Ong, KL3
Wat, NMS2
Janus, ED4
Xu, A2 2 1
Lam, KSL2 1
 
Issue Date2012
 
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
 
CitationClinical Endocrinology, 2012, v. 76 n. 4, p. 506-513 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2265.2011.04178.x
 
AbstractObjectives: Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectional studies also demonstrated plasma PEDF concentration correlated positively with systolic blood pressure (BP) and pulse pressure, and inversely with small artery elasticity. Here we investigated the relationship of plasma PEDF concentration with BP and incident hypertension in a 10-year prospective study. Methods: Baseline plasma PEDF concentrations were measured by ELISA in 520 Chinese subjects, aged 51 ± 12 years, followed up long-term from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study. The association between plasma PEDF concentration and BP was investigated in both cross-sectional and prospective studies, using multiple linear regression and path analyses. Cox proportional hazards analysis was used to determine whether baseline PEDF concentration was independently related to the subsequent development of hypertension over 10 years. Results: Baseline plasma concentrations of PEDF were higher in men (P < 0.001), and were directly related to systolic BP at 2 and 5 years, and to diastolic BP at 2 years, after adjustment for covariates. Of the 386 normotensive subjects at baseline, high baseline PEDF concentration was predictive of incident hypertension, independent of the effects of age, sex, baseline BP and obesity parameters (hazard ratio: 1.135; 95% CI: 1.039-1.241; P = 0.005). Conclusion: Our data suggest that plasma PEDF concentration is significantly associated with BP, and incident hypertension. PEDF may be involved in the pathogenesis of hypertension in humans. © 2012 Blackwell Publishing Ltd.
 
ISSN0300-0664
2012 Impact Factor: 3.396
2012 SCImago Journal Rankings: 1.175
 
DOIhttp://dx.doi.org/10.1111/j.1365-2265.2011.04178.x
 
ISI Accession Number IDWOS:000301175400009
Funding AgencyGrant Number
Health and Health Services Research Fund06070951
Research Grant CouncilHKU3/09C
Funding Information:

This study was financially supported by the Health and Health Services Research Fund (06070951) to Annette WK Tso and Research Grant Council Collaborative Research Fund (HKU3/09C) to Karen SL Lam.

 
ReferencesReferences in Scopus
 
GrantsA population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
 
DC FieldValue
dc.contributor.authorChen, C
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLaw, LSC
 
dc.contributor.authorOng, KL
 
dc.contributor.authorWat, NMS
 
dc.contributor.authorJanus, ED
 
dc.contributor.authorXu, A
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-08-26T14:24:31Z
 
dc.date.available2011-08-26T14:24:31Z
 
dc.date.issued2012
 
dc.description.abstractObjectives: Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectional studies also demonstrated plasma PEDF concentration correlated positively with systolic blood pressure (BP) and pulse pressure, and inversely with small artery elasticity. Here we investigated the relationship of plasma PEDF concentration with BP and incident hypertension in a 10-year prospective study. Methods: Baseline plasma PEDF concentrations were measured by ELISA in 520 Chinese subjects, aged 51 ± 12 years, followed up long-term from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study. The association between plasma PEDF concentration and BP was investigated in both cross-sectional and prospective studies, using multiple linear regression and path analyses. Cox proportional hazards analysis was used to determine whether baseline PEDF concentration was independently related to the subsequent development of hypertension over 10 years. Results: Baseline plasma concentrations of PEDF were higher in men (P < 0.001), and were directly related to systolic BP at 2 and 5 years, and to diastolic BP at 2 years, after adjustment for covariates. Of the 386 normotensive subjects at baseline, high baseline PEDF concentration was predictive of incident hypertension, independent of the effects of age, sex, baseline BP and obesity parameters (hazard ratio: 1.135; 95% CI: 1.039-1.241; P = 0.005). Conclusion: Our data suggest that plasma PEDF concentration is significantly associated with BP, and incident hypertension. PEDF may be involved in the pathogenesis of hypertension in humans. © 2012 Blackwell Publishing Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationClinical Endocrinology, 2012, v. 76 n. 4, p. 506-513 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2265.2011.04178.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2265.2011.04178.x
 
dc.identifier.epage513
 
dc.identifier.hkuros213340
 
dc.identifier.hkuros208720
 
dc.identifier.isiWOS:000301175400009
Funding AgencyGrant Number
Health and Health Services Research Fund06070951
Research Grant CouncilHKU3/09C
Funding Information:

This study was financially supported by the Health and Health Services Research Fund (06070951) to Annette WK Tso and Research Grant Council Collaborative Research Fund (HKU3/09C) to Karen SL Lam.

 
dc.identifier.issn0300-0664
2012 Impact Factor: 3.396
2012 SCImago Journal Rankings: 1.175
 
dc.identifier.issue4
 
dc.identifier.pmid21777264
 
dc.identifier.scopuseid_2-s2.0-84863261213
 
dc.identifier.spage506
 
dc.identifier.urihttp://hdl.handle.net/10722/137410
 
dc.identifier.volume76
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofClinical Endocrinology
 
dc.relation.projectA population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.titlePlasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: A 10-year prospective study
 
dc.typeArticle
 
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<contributor.author>Law, LSC</contributor.author>
<contributor.author>Ong, KL</contributor.author>
<contributor.author>Wat, NMS</contributor.author>
<contributor.author>Janus, ED</contributor.author>
<contributor.author>Xu, A</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
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<description.abstract>Objectives: Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectional studies also demonstrated plasma PEDF concentration correlated positively with systolic blood pressure (BP) and pulse pressure, and inversely with small artery elasticity. Here we investigated the relationship of plasma PEDF concentration with BP and incident hypertension in a 10-year prospective study. Methods: Baseline plasma PEDF concentrations were measured by ELISA in 520 Chinese subjects, aged 51 &#177; 12 years, followed up long-term from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study. The association between plasma PEDF concentration and BP was investigated in both cross-sectional and prospective studies, using multiple linear regression and path analyses. Cox proportional hazards analysis was used to determine whether baseline PEDF concentration was independently related to the subsequent development of hypertension over 10 years. Results: Baseline plasma concentrations of PEDF were higher in men (P &lt; 0.001), and were directly related to systolic BP at 2 and 5 years, and to diastolic BP at 2 years, after adjustment for covariates. Of the 386 normotensive subjects at baseline, high baseline PEDF concentration was predictive of incident hypertension, independent of the effects of age, sex, baseline BP and obesity parameters (hazard ratio: 1.135; 95% CI: 1.039-1.241; P = 0.005). Conclusion: Our data suggest that plasma PEDF concentration is significantly associated with BP, and incident hypertension. PEDF may be involved in the pathogenesis of hypertension in humans. &#169; 2012 Blackwell Publishing Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Heart Research Institute Australia
  4. University of Melbourne