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Article: Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B
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TitleAssociation of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B
 
AuthorsYeung, P1
Wong, DKH1
Lai, CL1
Fung, J1
Seto, WK1
Yuen, MF1
 
Issue Date2011
 
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
CitationJournal Of Infectious Diseases, 2011, v. 203 n. 5, p. 646-654 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jiq096
 
AbstractBackground. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). Methods. Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in the 3′ end of pre-S1 and 5′ end of pre-S2 regions. Adjusted for confounding risk factors, patients with HCC had a higher prevalence of HBV with pre-S deletions than did patients withoutHCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P=.018; odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1 deletions were significantly associated with the development of HCC (P = .020). A higher prevalence of pre-S deletions was observed in HBV isolates from HCC patients under the age of 50 years than fromthose older than 50 years (10 [62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo pre-S deletions was documented before the development of HCC. Conclusions. HBV pre-S2 deletions were an independent factor associated with the development of HCC. Its oncogenic role may be more important in young patients with HCC. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
 
ISSN0022-1899
2013 Impact Factor: 5.778
 
DOIhttp://dx.doi.org/10.1093/infdis/jiq096
 
PubMed Central IDPMC3072715
 
ISI Accession Number IDWOS:000287028000011
Funding AgencyGrant Number
Department of Medicine, The University of Hong Kong
Funding Information:

Hepatology Research Fund, Department of Medicine, The University of Hong Kong

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYeung, P
 
dc.contributor.authorWong, DKH
 
dc.contributor.authorLai, CL
 
dc.contributor.authorFung, J
 
dc.contributor.authorSeto, WK
 
dc.contributor.authorYuen, MF
 
dc.date.accessioned2011-08-26T14:24:14Z
 
dc.date.available2011-08-26T14:24:14Z
 
dc.date.issued2011
 
dc.description.abstractBackground. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). Methods. Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in the 3′ end of pre-S1 and 5′ end of pre-S2 regions. Adjusted for confounding risk factors, patients with HCC had a higher prevalence of HBV with pre-S deletions than did patients withoutHCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P=.018; odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1 deletions were significantly associated with the development of HCC (P = .020). A higher prevalence of pre-S deletions was observed in HBV isolates from HCC patients under the age of 50 years than fromthose older than 50 years (10 [62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo pre-S deletions was documented before the development of HCC. Conclusions. HBV pre-S2 deletions were an independent factor associated with the development of HCC. Its oncogenic role may be more important in young patients with HCC. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal Of Infectious Diseases, 2011, v. 203 n. 5, p. 646-654 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jiq096
 
dc.identifier.doihttp://dx.doi.org/10.1093/infdis/jiq096
 
dc.identifier.epage654
 
dc.identifier.hkuros189867
 
dc.identifier.hkuros188146
 
dc.identifier.hkuros213685
 
dc.identifier.isiWOS:000287028000011
Funding AgencyGrant Number
Department of Medicine, The University of Hong Kong
Funding Information:

Hepatology Research Fund, Department of Medicine, The University of Hong Kong

 
dc.identifier.issn0022-1899
2013 Impact Factor: 5.778
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3072715
 
dc.identifier.pmid21227916
 
dc.identifier.scopuseid_2-s2.0-79751523518
 
dc.identifier.spage646
 
dc.identifier.urihttp://hdl.handle.net/10722/137388
 
dc.identifier.volume203
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Infectious Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCarcinoma, Hepatocellular - epidemiology - genetics - virology
 
dc.subject.meshGene Deletion
 
dc.subject.meshHepatitis B virus - chemistry - classification - genetics
 
dc.subject.meshHepatitis B, Chronic - complications - genetics - virology
 
dc.subject.meshLiver Neoplasms - epidemiology - genetics - virology
 
dc.titleAssociation of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong