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Article: Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B

TitleAssociation of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B
Authors
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2011, v. 203 n. 5, p. 646-654 How to Cite?
AbstractBackground. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). Methods. Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in the 3′ end of pre-S1 and 5′ end of pre-S2 regions. Adjusted for confounding risk factors, patients with HCC had a higher prevalence of HBV with pre-S deletions than did patients withoutHCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P=.018; odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1 deletions were significantly associated with the development of HCC (P = .020). A higher prevalence of pre-S deletions was observed in HBV isolates from HCC patients under the age of 50 years than fromthose older than 50 years (10 [62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo pre-S deletions was documented before the development of HCC. Conclusions. HBV pre-S2 deletions were an independent factor associated with the development of HCC. Its oncogenic role may be more important in young patients with HCC. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/137388
ISSN
2014 Impact Factor: 5.997
2014 SCImago Journal Rankings: 3.190
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Department of Medicine, The University of Hong Kong
Funding Information:

Hepatology Research Fund, Department of Medicine, The University of Hong Kong

References

 

DC FieldValueLanguage
dc.contributor.authorYeung, Pen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2011-08-26T14:24:14Z-
dc.date.available2011-08-26T14:24:14Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2011, v. 203 n. 5, p. 646-654en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/137388-
dc.description.abstractBackground. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). Methods. Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in the 3′ end of pre-S1 and 5′ end of pre-S2 regions. Adjusted for confounding risk factors, patients with HCC had a higher prevalence of HBV with pre-S deletions than did patients withoutHCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P=.018; odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1 deletions were significantly associated with the development of HCC (P = .020). A higher prevalence of pre-S deletions was observed in HBV isolates from HCC patients under the age of 50 years than fromthose older than 50 years (10 [62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo pre-S deletions was documented before the development of HCC. Conclusions. HBV pre-S2 deletions were an independent factor associated with the development of HCC. Its oncogenic role may be more important in young patients with HCC. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subject.meshCarcinoma, Hepatocellular - epidemiology - genetics - virologyen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHepatitis B virus - chemistry - classification - geneticsen_US
dc.subject.meshHepatitis B, Chronic - complications - genetics - virologyen_US
dc.subject.meshLiver Neoplasms - epidemiology - genetics - virologyen_US
dc.titleAssociation of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=203&issue=5&spage=646&epage=654&date=2011&atitle=Association+of+hepatitis+B+virus+pre-S+deletions+with+the+development+of+hepatocellular+carcinoma+in+chronic+hepatitis+Ben_US
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/infdis/jiq096en_HK
dc.identifier.pmid21227916-
dc.identifier.pmcidPMC3072715en_US
dc.identifier.scopuseid_2-s2.0-79751523518en_HK
dc.identifier.hkuros189867en_US
dc.identifier.hkuros188146en_US
dc.identifier.hkuros213685-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79751523518&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume203en_HK
dc.identifier.issue5en_HK
dc.identifier.spage646en_HK
dc.identifier.epage654en_HK
dc.identifier.isiWOS:000287028000011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYeung, P=35081534000en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

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