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Conference Paper: Physical Activity Intervention in Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

TitlePhysical Activity Intervention in Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors
Issue Date2010
PublisherThe National Cancer Research Institute (NCRI).
Citation
The 6th National Cancer Research Institute (NCRI) Cancer Conference, Liverpool, UK., 7-10 November 2010. How to Cite?
AbstractBackground The aim was to systematically review all published randomized controlled trials (RCTs) which tested the effect of a physical activity intervention in adult cancer survivors after the main cancer treatment. Method Relevant RCTs were located by: (1) systematic searching of electronic databases (PUBMED and Google Scholar) using cancer-related and exercise-related search terms; and (2) scanning the references of retrieved RCTs and relevant reviews. All relevant RCTs were retrieved and assessed to determine if they met the selection criteria. Data extraction was independently performed by two investigators and followed by a discussion to reach consensus. The main outcome measures were cancer outcome (survival and recurrence), quality of life (QoL), body composition and functional capacity. Results A total of 2,447 citations were identified of which 170 potentially relevant ones were examined in detail. Forty-five papers met the selection criteria of which 41 reported data on at least one relevant outcome. These encompassed 18 papers not included in previously published reviews. Twenty-six papers (63.4%) were on breast cancers and the remaining papers were on other cancers. There was a paucity of published data on the effects of physical activity interventions on cancer outcome. Various instruments were used to assess the other outcomes (QoL and functional capacity) limiting the pooling of data for meta-analysis. Estimates of the effects of physical activity interventions on QoL, body composition and functional capacity were determined. Potential determinants of the effect heterogeneity across studies were evaluated. Conclusion Moderately-strong-to-strong evidence was found for a positive effect of physical activity interventions on QoL of adult cancer survivors following main cancer treatment. Clinically meaningful associations were identified between such interventions and improved functional capacity. The observed heterogeneity in study design and outcome parameters highlighted the need for the development of a standardized protocol to facilitate meta-analysis on the effects of physical activity in cancer survivors. Acknowledgements This study has been supported by WCRF UK, WCRF International and WCRF Hong Kong.
DescriptionProffered paper session: Information, patients and the public/ Survivorship and end of life care
Persistent Identifierhttp://hdl.handle.net/10722/136525

 

DC FieldValueLanguage
dc.contributor.authorHo, JWCen_US
dc.contributor.authorHui, Ben_US
dc.contributor.authorFong, DYTen_US
dc.contributor.authorMacfarlane, DJen_US
dc.contributor.authorLee, AMen_US
dc.contributor.authorLeung, SSKen_US
dc.contributor.authorCerin, Een_US
dc.contributor.authorChan, Wen_US
dc.contributor.authorLeung, Ien_US
dc.contributor.authorLam, Sen_US
dc.contributor.authorTaylor, AJen_US
dc.contributor.authorCheng, KKen_US
dc.date.accessioned2011-07-27T02:17:39Z-
dc.date.available2011-07-27T02:17:39Z-
dc.date.issued2010en_US
dc.identifier.citationThe 6th National Cancer Research Institute (NCRI) Cancer Conference, Liverpool, UK., 7-10 November 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/136525-
dc.descriptionProffered paper session: Information, patients and the public/ Survivorship and end of life care-
dc.description.abstractBackground The aim was to systematically review all published randomized controlled trials (RCTs) which tested the effect of a physical activity intervention in adult cancer survivors after the main cancer treatment. Method Relevant RCTs were located by: (1) systematic searching of electronic databases (PUBMED and Google Scholar) using cancer-related and exercise-related search terms; and (2) scanning the references of retrieved RCTs and relevant reviews. All relevant RCTs were retrieved and assessed to determine if they met the selection criteria. Data extraction was independently performed by two investigators and followed by a discussion to reach consensus. The main outcome measures were cancer outcome (survival and recurrence), quality of life (QoL), body composition and functional capacity. Results A total of 2,447 citations were identified of which 170 potentially relevant ones were examined in detail. Forty-five papers met the selection criteria of which 41 reported data on at least one relevant outcome. These encompassed 18 papers not included in previously published reviews. Twenty-six papers (63.4%) were on breast cancers and the remaining papers were on other cancers. There was a paucity of published data on the effects of physical activity interventions on cancer outcome. Various instruments were used to assess the other outcomes (QoL and functional capacity) limiting the pooling of data for meta-analysis. Estimates of the effects of physical activity interventions on QoL, body composition and functional capacity were determined. Potential determinants of the effect heterogeneity across studies were evaluated. Conclusion Moderately-strong-to-strong evidence was found for a positive effect of physical activity interventions on QoL of adult cancer survivors following main cancer treatment. Clinically meaningful associations were identified between such interventions and improved functional capacity. The observed heterogeneity in study design and outcome parameters highlighted the need for the development of a standardized protocol to facilitate meta-analysis on the effects of physical activity in cancer survivors. Acknowledgements This study has been supported by WCRF UK, WCRF International and WCRF Hong Kong.-
dc.languageengen_US
dc.publisherThe National Cancer Research Institute (NCRI).-
dc.relation.ispartofNational Cancer Research Institute (NCRI) Cancer Conferenceen_US
dc.titlePhysical Activity Intervention in Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trialsen_US
dc.typeConference_Paperen_US
dc.identifier.emailHo, JWC: judyho@hkucc.hku.hken_US
dc.identifier.emailFong, DYT: dytfong@hku.hken_US
dc.identifier.emailMacfarlane, DJ: djmac@hku.hken_US
dc.identifier.emailLee, AM: amlee@hkucc.hku.hken_US
dc.identifier.emailLeung, SSK: sleung@hku.hken_US
dc.identifier.emailCerin, E: ecerin@hku.hken_US
dc.identifier.authorityFong, DYT=rp00253en_US
dc.identifier.authorityMacfarlane, DJ=rp00934en_US
dc.identifier.authorityLee, AM=rp00483en_US
dc.identifier.authorityLeung, SSK=rp00493en_US
dc.identifier.authorityCerin, E=rp00890en_US
dc.identifier.hkuros187135en_US
dc.publisher.placeUnited Kingdom-

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