Article: Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong
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- Publisher Website: 10.1016/j.jhin.2011.02.017
- Scopus: eid_2-s2.0-79960184071
- PMID: 21501896
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| Title | Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Zhou, Y2 Ng, DMW2 Seto, WH1 Ip, DKM2 Kwok, HKH1 Ma, ESK2 Ng, S2 Lau, LLH2 Wu, JT2 Peiris, JSM2 3 Cowling, BJ2 | ||||||||||
| Keywords | H1N1 Healthcare workers Influenza Pandemic Seroprevalence | ||||||||||
| Issue Date | 2011 | ||||||||||
| Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin | ||||||||||
| Citation | Journal Of Hospital Infection, 2011, v. 78 n. 4, p. 308-311 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jhin.2011.02.017 | ||||||||||
| Abstract | During the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave. © 2011 The Healthcare Infection Society. | ||||||||||
| ISSN | 0195-6701 2011 Impact Factor: 3.393 2011 SCImago Journal Rankings: 0.256 | ||||||||||
| DOI | http://dx.doi.org/10.1016/j.jhin.2011.02.017 | ||||||||||
| ISI Accession Number ID | WOS:000292682400013
Funding Information: B.J.C. has received research funding from MedImmune Inc., a manufacturer of influenza vaccines. D.K.M.I. has received research funding from Roche. The authors report no other potential conflicts of interest. | ||||||||||
| References | References in Scopus | ||||||||||
| Grants | Control of Pandemic and Inter-pandemic Influenza A detailed longitudinal study of infection attack rates among healthy adults in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009 |
| dc.contributor.author | Zhou, Y | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Ng, DMW | ||||||||||
| dc.contributor.author | Seto, WH | ||||||||||
| dc.contributor.author | Ip, DKM | ||||||||||
| dc.contributor.author | Kwok, HKH | ||||||||||
| dc.contributor.author | Ma, ESK | ||||||||||
| dc.contributor.author | Ng, S | ||||||||||
| dc.contributor.author | Lau, LLH | ||||||||||
| dc.contributor.author | Wu, JT | ||||||||||
| dc.contributor.author | Peiris, JSM | ||||||||||
| dc.contributor.author | Cowling, BJ | ||||||||||
| dc.date.accessioned | 2011-07-27T01:39:00Z | ||||||||||
| dc.date.available | 2011-07-27T01:39:00Z | ||||||||||
| dc.date.issued | 2011 | ||||||||||
| dc.description.abstract | During the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave. © 2011 The Healthcare Infection Society. | ||||||||||
| dc.description.grant | Control of Pandemic and Inter-pandemic Influenza | ||||||||||
| dc.description.grant | A detailed longitudinal study of infection attack rates among healthy adults in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009 | ||||||||||
| dc.description.grantcode | 97655 | ||||||||||
| dc.description.grantcode | 100759 | ||||||||||
| dc.description.nature | postprint | ||||||||||
| dc.identifier.citation | Journal Of Hospital Infection, 2011, v. 78 n. 4, p. 308-311 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jhin.2011.02.017 | ||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.jhin.2011.02.017 | ||||||||||
| dc.identifier.epage | 311 | ||||||||||
| dc.identifier.hkuros | 188109 | ||||||||||
| dc.identifier.isi | WOS:000292682400013
Funding Information: B.J.C. has received research funding from MedImmune Inc., a manufacturer of influenza vaccines. D.K.M.I. has received research funding from Roche. The authors report no other potential conflicts of interest. | ||||||||||
| dc.identifier.issn | 0195-6701 2011 Impact Factor: 3.393 2011 SCImago Journal Rankings: 0.256 | ||||||||||
| dc.identifier.issue | 4 | ||||||||||
| dc.identifier.openurl | | ||||||||||
| dc.identifier.pmid | 21501896 | ||||||||||
| dc.identifier.scopus | eid_2-s2.0-79960184071 | ||||||||||
| dc.identifier.spage | 308 | ||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/135667 | ||||||||||
| dc.identifier.volume | 78 | ||||||||||
| dc.language | eng | ||||||||||
| dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin | ||||||||||
| dc.publisher.place | United Kingdom | ||||||||||
| dc.relation.ispartof | Journal of Hospital Infection | ||||||||||
| dc.relation.references | References in Scopus | ||||||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||||||
| dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication inJournal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Hospital Infection, 2011, v. 78 n. 4, p. 308-311. DOI: 10.1016/j.jhin.2011.02.017 | ||||||||||
| dc.subject | H1N1 | ||||||||||
| dc.subject | Healthcare workers | ||||||||||
| dc.subject | Influenza | ||||||||||
| dc.subject | Pandemic | ||||||||||
| dc.subject | Seroprevalence | ||||||||||
| dc.title | Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong | ||||||||||
| dc.type | Article |
Author Affiliations
- Hong Kong Hospital Authority
- The University of Hong Kong
- HKU-Pasteur Research Centre