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Article: Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong
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TitleSeroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong
 
AuthorsZhou, Y2
Ng, DMW2
Seto, WH1
Ip, DKM2
Kwok, HKH1
Ma, ESK2
Ng, S2
Lau, LLH2
Wu, JT2
Peiris, JSM2 3
Cowling, BJ2
 
KeywordsH1N1
Healthcare workers
Influenza
Pandemic
Seroprevalence
 
Issue Date2011
 
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin
 
CitationJournal Of Hospital Infection, 2011, v. 78 n. 4, p. 308-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhin.2011.02.017
 
AbstractDuring the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave. © 2011 The Healthcare Infection Society.
 
ISSN0195-6701
2012 Impact Factor: 2.855
2012 SCImago Journal Rankings: 1.213
 
DOIhttp://dx.doi.org/10.1016/j.jhin.2011.02.017
 
ISI Accession Number IDWOS:000292682400013
Funding AgencyGrant Number
MedImmune Inc.
Roche
Hong Kong University Grants CommitteeAoE/M-12/06
Food and Health Bureau, Government of the Hong Kong SARPHE-20
Funding Information:

B.J.C. has received research funding from MedImmune Inc., a manufacturer of influenza vaccines. D.K.M.I. has received research funding from Roche. The authors report no other potential conflicts of interest.

 
ReferencesReferences in Scopus
 
GrantsControl of Pandemic and Inter-pandemic Influenza
A detailed longitudinal study of infection attack rates among healthy adults in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009
 
DC FieldValue
dc.contributor.authorZhou, Y
 
dc.contributor.authorNg, DMW
 
dc.contributor.authorSeto, WH
 
dc.contributor.authorIp, DKM
 
dc.contributor.authorKwok, HKH
 
dc.contributor.authorMa, ESK
 
dc.contributor.authorNg, S
 
dc.contributor.authorLau, LLH
 
dc.contributor.authorWu, JT
 
dc.contributor.authorPeiris, JSM
 
dc.contributor.authorCowling, BJ
 
dc.date.accessioned2011-07-27T01:39:00Z
 
dc.date.available2011-07-27T01:39:00Z
 
dc.date.issued2011
 
dc.description.abstractDuring the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave. © 2011 The Healthcare Infection Society.
 
dc.description.naturepostprint
 
dc.identifier.citationJournal Of Hospital Infection, 2011, v. 78 n. 4, p. 308-311 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhin.2011.02.017
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jhin.2011.02.017
 
dc.identifier.epage311
 
dc.identifier.hkuros188109
 
dc.identifier.isiWOS:000292682400013
Funding AgencyGrant Number
MedImmune Inc.
Roche
Hong Kong University Grants CommitteeAoE/M-12/06
Food and Health Bureau, Government of the Hong Kong SARPHE-20
Funding Information:

B.J.C. has received research funding from MedImmune Inc., a manufacturer of influenza vaccines. D.K.M.I. has received research funding from Roche. The authors report no other potential conflicts of interest.

 
dc.identifier.issn0195-6701
2012 Impact Factor: 2.855
2012 SCImago Journal Rankings: 1.213
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid21501896
 
dc.identifier.scopuseid_2-s2.0-79960184071
 
dc.identifier.spage308
 
dc.identifier.urihttp://hdl.handle.net/10722/135667
 
dc.identifier.volume78
 
dc.languageeng
 
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Hospital Infection
 
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza
 
dc.relation.projectA detailed longitudinal study of infection attack rates among healthy adults in Hong Kong during the epidemic of the human swine influenza A/H1N1 virus in 2009
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication inJournal of Hospital Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Hospital Infection, 2011, v. 78 n. 4, p. 308-311. DOI: 10.1016/j.jhin.2011.02.017
 
dc.subjectH1N1
 
dc.subjectHealthcare workers
 
dc.subjectInfluenza
 
dc.subjectPandemic
 
dc.subjectSeroprevalence
 
dc.titleSeroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong
 
dc.typeArticle
 
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Author Affiliations
  1. Hong Kong Hospital Authority
  2. The University of Hong Kong
  3. HKU-Pasteur Research Centre