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Article: Life long endogenous estrogen exposure and later adulthood cognitive function in a population of naturally postmenopausal women from Southern China: The Guangzhou Biobank Cohort Study

TitleLife long endogenous estrogen exposure and later adulthood cognitive function in a population of naturally postmenopausal women from Southern China: The Guangzhou Biobank Cohort Study
Authors
KeywordsBreast feeding
China
Cognition
Cohort studies
Menarche
Menopause
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/psyneuen
Citation
Psychoneuroendocrinology, 2011, v. 36 n. 6, p. 864-873 How to Cite?
AbstractBackground: Estrogen has neurotrophic and neuroprotective properties in animal and in vitro studies. Epidemiological studies are inconclusive, but suggest a positive association between endogenous estrogen exposure (measured by reproductive period, the number of years between menarche and menopause) and later life cognitive function. Methods: Structural equation modeling was used in a cross-sectional study of 11,094 naturally postmenopausal multiparous Chinese older (≥50 years) women from the Guangzhou Biobank Cohort Study (phases 2 and 3) to assess the interrelationship of four proxies of higher endogenous estrogen exposure (longer reproductive period, older age of first pregnancy, lower parity and shorter average duration of breast feeding per child) with immediate and the delayed 10-word recall score in phases 2 and 3, and with the mini-mental state examination (MMSE) score in phase 3 (5641 women). Results: Adjusted for age, education, childhood and adulthood socio-economic position and physical activity, longer reproductive period was associated with higher scores (0.02 words per year, 95% confidence interval (CI) 0.008-0.02 for delayed recall and 0.05 MMSE score, 95%CI 0.04-0.07, respectively). Lower parity and shorter average duration of breast-feeding per child were also associated with better cognitive function. Conclusions: In a large cohort of naturally postmenopausal Chinese women proxies of greater endogenous estrogen exposure were associated with better cognitive function. These findings support biological evidence for a cognitively protective role of endogenous estrogen. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/135664
ISSN
2015 Impact Factor: 4.704
2015 SCImago Journal Rankings: 2.740
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK. These funding bodies had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

References

 

DC FieldValueLanguage
dc.contributor.authorHeys, Men_HK
dc.contributor.authorJiang, Cen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorYeung, SLAen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorSchooling, CMen_HK
dc.date.accessioned2011-07-27T01:38:58Z-
dc.date.available2011-07-27T01:38:58Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychoneuroendocrinology, 2011, v. 36 n. 6, p. 864-873en_HK
dc.identifier.issn0306-4530en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135664-
dc.description.abstractBackground: Estrogen has neurotrophic and neuroprotective properties in animal and in vitro studies. Epidemiological studies are inconclusive, but suggest a positive association between endogenous estrogen exposure (measured by reproductive period, the number of years between menarche and menopause) and later life cognitive function. Methods: Structural equation modeling was used in a cross-sectional study of 11,094 naturally postmenopausal multiparous Chinese older (≥50 years) women from the Guangzhou Biobank Cohort Study (phases 2 and 3) to assess the interrelationship of four proxies of higher endogenous estrogen exposure (longer reproductive period, older age of first pregnancy, lower parity and shorter average duration of breast feeding per child) with immediate and the delayed 10-word recall score in phases 2 and 3, and with the mini-mental state examination (MMSE) score in phase 3 (5641 women). Results: Adjusted for age, education, childhood and adulthood socio-economic position and physical activity, longer reproductive period was associated with higher scores (0.02 words per year, 95% confidence interval (CI) 0.008-0.02 for delayed recall and 0.05 MMSE score, 95%CI 0.04-0.07, respectively). Lower parity and shorter average duration of breast-feeding per child were also associated with better cognitive function. Conclusions: In a large cohort of naturally postmenopausal Chinese women proxies of greater endogenous estrogen exposure were associated with better cognitive function. These findings support biological evidence for a cognitively protective role of endogenous estrogen. © 2010 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/psyneuenen_HK
dc.relation.ispartofPsychoneuroendocrinologyen_HK
dc.subjectBreast feedingen_HK
dc.subjectChinaen_HK
dc.subjectCognitionen_HK
dc.subjectCohort studiesen_HK
dc.subjectMenarcheen_HK
dc.subjectMenopauseen_HK
dc.subject.meshChina-
dc.subject.meshCognition - physiology-
dc.subject.meshEstrogens - physiology-
dc.subject.meshPostmenopause - blood - psychology-
dc.subject.meshReproductive History-
dc.titleLife long endogenous estrogen exposure and later adulthood cognitive function in a population of naturally postmenopausal women from Southern China: The Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-4530&volume=36&issue=6&spage=864&epage=873&date=2011&atitle=Life+long+endogenous+estrogen+exposure+and+later+adulthood+cognitive+function+in+a+population+of+naturally+postmenopausal+women+from+Southern+China:+the+Guangzhou+Biobank+Cohort+Study-
dc.identifier.emailHeys, M: m_heys@lycos.comen_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hken_HK
dc.identifier.authorityHeys, M=rp00257en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authoritySchooling, CM=rp00504en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.psyneuen.2010.11.009en_HK
dc.identifier.pmid21185655-
dc.identifier.scopuseid_2-s2.0-79956333348en_HK
dc.identifier.hkuros187484en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956333348&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue6en_HK
dc.identifier.spage864en_HK
dc.identifier.epage873en_HK
dc.identifier.isiWOS:000292237500011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHeys, M=22234232400en_HK
dc.identifier.scopusauthoridJiang, C=10639500500en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridZhang, W=14833531400en_HK
dc.identifier.scopusauthoridYeung, SLA=52165012300en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridSchooling, CM=12808565000en_HK
dc.identifier.citeulike8601908-

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