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Article: Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination

TitleEvaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination
Authors
KeywordsAntimullerian hormone
controlled ovarian stimulation
intrauterine insemination
live birth
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 2010, v. 94 n. 6, p. 2177-2181 How to Cite?
AbstractObjective: To evaluate the role of serum antimullerian hormone (AMH) concentration in predicting live birth outcome in controlled ovarian stimulation and intrauterine insemination (IUI). Design: Retrospective analysis. Setting: Tertiary assisted reproduction unit. Patients: 243 patients undergoing IUI treatment. Intervention(s): Archived early follicular phase serum samples taken at the start of the first treatment cycle before ovarian stimulation were retrieved from patients undergoing IUI treatment. Main Outcome Measure(s): First-cycle and cumulative live birth rates. Result(s): Patients attaining a successful live birth, either in the first cycle or cumulatively after three cycles, had significantly higher serum AMH concentrations than those failing treatment. Serum AMH concentration correlated positively with antral follicle count (AFC) and duration of stimulation and inversely with maternal age, serum FSH concentration, and total dose of gonadotropin used. After controlling for age, body mass index, AFC, and FSH, AMH remained the only significant predictor of cumulative live birth. The area under the receiver operating characteristic curve was 0.668 in predicting cumulative live birth. Serum AMH concentration was significantly higher in overresponders. Conclusion(s): Serum AMH concentration was significantly higher in subjects with a live birth from the first cycle or after three cycles of stimulated IUI treatment compared with those failing treatment. Serum AMH concentration has a modest predictive value on ovarian overresponse. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135634
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

Supported by the Committee on Research and Conference Grants, University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, HWRen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorHo, PCen_HK
dc.contributor.authorNg, EHYen_HK
dc.date.accessioned2011-07-27T01:38:10Z-
dc.date.available2011-07-27T01:38:10Z-
dc.date.issued2010en_HK
dc.identifier.citationFertility And Sterility, 2010, v. 94 n. 6, p. 2177-2181en_HK
dc.identifier.issn0015-0282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135634-
dc.description.abstractObjective: To evaluate the role of serum antimullerian hormone (AMH) concentration in predicting live birth outcome in controlled ovarian stimulation and intrauterine insemination (IUI). Design: Retrospective analysis. Setting: Tertiary assisted reproduction unit. Patients: 243 patients undergoing IUI treatment. Intervention(s): Archived early follicular phase serum samples taken at the start of the first treatment cycle before ovarian stimulation were retrieved from patients undergoing IUI treatment. Main Outcome Measure(s): First-cycle and cumulative live birth rates. Result(s): Patients attaining a successful live birth, either in the first cycle or cumulatively after three cycles, had significantly higher serum AMH concentrations than those failing treatment. Serum AMH concentration correlated positively with antral follicle count (AFC) and duration of stimulation and inversely with maternal age, serum FSH concentration, and total dose of gonadotropin used. After controlling for age, body mass index, AFC, and FSH, AMH remained the only significant predictor of cumulative live birth. The area under the receiver operating characteristic curve was 0.668 in predicting cumulative live birth. Serum AMH concentration was significantly higher in overresponders. Conclusion(s): Serum AMH concentration was significantly higher in subjects with a live birth from the first cycle or after three cycles of stimulated IUI treatment compared with those failing treatment. Serum AMH concentration has a modest predictive value on ovarian overresponse. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_HK
dc.relation.ispartofFertility and Sterilityen_HK
dc.subjectAntimullerian hormoneen_HK
dc.subjectcontrolled ovarian stimulationen_HK
dc.subjectintrauterine inseminationen_HK
dc.subjectlive birthen_HK
dc.subject.meshAnti-Mullerian Hormone - analysis - blood-
dc.subject.meshInfertility - blood - diagnosis - therapy-
dc.subject.meshInsemination, Artificial - methods-
dc.subject.meshOvulation Induction - adverse effects - methods-
dc.subject.meshPregnancy Rate-
dc.titleEvaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine inseminationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0015-0282&volume=94&issue=6&spage=2177&epage=2181&date=2010&atitle=Evaluating+the+performance+of+serum+antimullerian+hormone+concentration+in+predicting+the+live+birth+rate+of+controlled+ovarian+stimulation+and+intrauterine+insemination-
dc.identifier.emailLi, HWR: raymondli@hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.authorityLi, HWR=rp01649en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fertnstert.2009.12.059en_HK
dc.identifier.pmid20171627-
dc.identifier.scopuseid_2-s2.0-77956183222en_HK
dc.identifier.hkuros187016en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956183222&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2177en_HK
dc.identifier.epage2181en_HK
dc.identifier.isiWOS:000283441400045-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, HWR=8554164300en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK

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