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Article: Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma

TitleOverexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma
Authors
KeywordsHepatectomy
Hepatocellular carcinoma
Matrix metalloproteinase-12
Metastasis
Recurrence
Survival
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
Citation
European Journal Of Cancer, 2011, v. 47 n. 15, p. 2299-2305 How to Cite?
AbstractTumour recurrence and metastasis are pressing issues of hepatocellular carcinoma (HCC) patients who receive surgical treatments. Matrix metalloproteinase-12 (MMP-12), previously identified from our animal model, is involved in tumour invasiveness of rat hepatoma. We aimed to investigate the significance and prognostic value of MMP-12 expression in human HCC. MMP-12 mRNA level of 139 pairs of tumour and non-tumour liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time RT-PCR. MMP-12 mRNA was significantly elevated in tumour liver tissues of HCC patients compared to non-tumour and normal liver tissues. By comparing paired tumour and non-tumour liver tissues, MMP-12 mRNA was overexpressed in 58% of tumour tissue of HCC patients. Overexpression of MMP-12 mRNA was significantly correlated with presence of venous infiltration (p = 0.004), high serum AFP level (p = 0.012), early tumour recurrence (p = 0.018) and poor overall survival (p = 0.02) of HCC patients. Moreover, MMP-12 mRNA was an independent factor in predicting the 1- and 3-year overall survival of HCC patients after hepatectomy. Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/135521
ISSN
2015 Impact Factor: 6.163
2015 SCImago Journal Rankings: 3.152
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council Hong KongHKU5/CRF/08
Funding Information:

This study was supported by the Collaborative Research Fund (HKU5/CRF/08) of the Research Grant Council Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorNg, KTPen_HK
dc.contributor.authorQi, Xen_HK
dc.contributor.authorKong, KLen_HK
dc.contributor.authorCheung, BYYen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorMan, Ken_HK
dc.date.accessioned2011-07-27T01:36:26Z-
dc.date.available2011-07-27T01:36:26Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal Of Cancer, 2011, v. 47 n. 15, p. 2299-2305en_HK
dc.identifier.issn0959-8049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135521-
dc.description.abstractTumour recurrence and metastasis are pressing issues of hepatocellular carcinoma (HCC) patients who receive surgical treatments. Matrix metalloproteinase-12 (MMP-12), previously identified from our animal model, is involved in tumour invasiveness of rat hepatoma. We aimed to investigate the significance and prognostic value of MMP-12 expression in human HCC. MMP-12 mRNA level of 139 pairs of tumour and non-tumour liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time RT-PCR. MMP-12 mRNA was significantly elevated in tumour liver tissues of HCC patients compared to non-tumour and normal liver tissues. By comparing paired tumour and non-tumour liver tissues, MMP-12 mRNA was overexpressed in 58% of tumour tissue of HCC patients. Overexpression of MMP-12 mRNA was significantly correlated with presence of venous infiltration (p = 0.004), high serum AFP level (p = 0.012), early tumour recurrence (p = 0.018) and poor overall survival (p = 0.02) of HCC patients. Moreover, MMP-12 mRNA was an independent factor in predicting the 1- and 3-year overall survival of HCC patients after hepatectomy. Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection. © 2011 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejcaen_HK
dc.relation.ispartofEuropean Journal of Canceren_HK
dc.subjectHepatectomyen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectMatrix metalloproteinase-12en_HK
dc.subjectMetastasisen_HK
dc.subjectRecurrenceen_HK
dc.subjectSurvivalen_HK
dc.titleOverexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-8049&volume=47&issue=15&spage=2299&epage=2305&date=2011&atitle=Overexpression+of+matrix+metalloproteinase-12+(MMP-12)+correlates+with+poor+prognosis+of+hepatocellular+carcinoma-
dc.identifier.emailNg, KTP: ledodes@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.authorityNg, KTP=rp01720en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejca.2011.05.032en_HK
dc.identifier.pmid21683576-
dc.identifier.scopuseid_2-s2.0-80053378588en_HK
dc.identifier.hkuros187489en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053378588&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue15en_HK
dc.identifier.spage2299en_HK
dc.identifier.epage2305en_HK
dc.identifier.isiWOS:000296393700007-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectLiver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury-
dc.identifier.scopusauthoridNg, KTP=7403178513en_HK
dc.identifier.scopusauthoridQi, X=53865455900en_HK
dc.identifier.scopusauthoridKong, KL=36106004300en_HK
dc.identifier.scopusauthoridCheung, BYY=53864701400en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK
dc.identifier.citeulike9491321-

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