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Article: Executive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test

TitleExecutive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test
Authors
KeywordsCognitive function
Executive function
First-episode schizophrenia
Longitudinal
Medication-naïve
Six elements
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2011, v. 126 n. 1-3, p. 87-92 How to Cite?
AbstractExecutive function impairment is a key cognitive deficit in schizophrenia. However, traditional neuropsychological tests of executive function may not be sensitive enough to capture the everyday dysexecutive problems experienced by patients. Additionally, existing literature has been inconsistent about longitudinal changes of executive functions in schizophrenia. The present study focuses on examining the longitudinal change of executive functions in schizophrenia using the Modified Six Elements Test (MSET) that was developed based on the Supervisory Attentional System model and shown to be sensitive to everyday dysexecutive problems. In the present study, MSET performance was assessed in 31 medication-naïve first-episode schizophrenic patients at four times over a period of three years, while the 31 normal controls were assessed once. Patients demonstrated impairment in MSET as compared to controls. Importantly, the MSET impairment persisted from the medication-naïve state to clinical stabilization and the three years following the first psychotic episode though patients improved in a conventional executive test (Modified Wisconsin Card Sorting Test). Performance was not related to intelligence, educational level, symptom changes, age-of-onset, or duration of untreated psychosis. Better MSET performance at medication-naïve state predicted improvement in negative and positive symptoms over the three-year period. These findings may suggest that MSET impairment is a primary deficit in schizophrenia that occurs early in the course of the illness and remains stable irrespective of clinical state for at least three years following the first episode of schizophrenia. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/135428
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, KCMen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2011-07-27T01:35:01Z-
dc.date.available2011-07-27T01:35:01Z-
dc.date.issued2011en_HK
dc.identifier.citationSchizophrenia Research, 2011, v. 126 n. 1-3, p. 87-92en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135428-
dc.description.abstractExecutive function impairment is a key cognitive deficit in schizophrenia. However, traditional neuropsychological tests of executive function may not be sensitive enough to capture the everyday dysexecutive problems experienced by patients. Additionally, existing literature has been inconsistent about longitudinal changes of executive functions in schizophrenia. The present study focuses on examining the longitudinal change of executive functions in schizophrenia using the Modified Six Elements Test (MSET) that was developed based on the Supervisory Attentional System model and shown to be sensitive to everyday dysexecutive problems. In the present study, MSET performance was assessed in 31 medication-naïve first-episode schizophrenic patients at four times over a period of three years, while the 31 normal controls were assessed once. Patients demonstrated impairment in MSET as compared to controls. Importantly, the MSET impairment persisted from the medication-naïve state to clinical stabilization and the three years following the first psychotic episode though patients improved in a conventional executive test (Modified Wisconsin Card Sorting Test). Performance was not related to intelligence, educational level, symptom changes, age-of-onset, or duration of untreated psychosis. Better MSET performance at medication-naïve state predicted improvement in negative and positive symptoms over the three-year period. These findings may suggest that MSET impairment is a primary deficit in schizophrenia that occurs early in the course of the illness and remains stable irrespective of clinical state for at least three years following the first episode of schizophrenia. © 2010 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCognitive functionen_HK
dc.subjectExecutive functionen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectLongitudinalen_HK
dc.subjectMedication-naïveen_HK
dc.subjectSix elementsen_HK
dc.subject.meshAge of Onset-
dc.subject.meshCognition Disorders - etiology-
dc.subject.meshExecutive Function - physiology-
dc.subject.meshSchizophrenia - complications-
dc.subject.meshSchizophrenic Psychology-
dc.titleExecutive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid testen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=126&issue=1-3&spage=87&epage=92&date=2011&atitle=Executive+function+in+first-episode+schizophrenia:+a+three-year+longitudinal+study+of+an+ecologically+valid+test-
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChan, SKW: kwsherry@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChan, SKW=rp00539en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2010.11.023en_HK
dc.identifier.pmid21194894-
dc.identifier.scopuseid_2-s2.0-79952009179en_HK
dc.identifier.hkuros187587en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952009179&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume126en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage87en_HK
dc.identifier.epage92en_HK
dc.identifier.isiWOS:000289025700013-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLiu, KCM=42461807300en_HK
dc.identifier.scopusauthoridChan, RCK=35725165500en_HK
dc.identifier.scopusauthoridChan, KKS=36448818400en_HK
dc.identifier.scopusauthoridTang, JYM=35086815700en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridChan, SKW=26424509100en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike8678481-

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