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Article: Left ventricular twisting and untwisting motion in childhood cancer survivors

TitleLeft ventricular twisting and untwisting motion in childhood cancer survivors
Authors
Keywordsanthracycline cardiotoxicity
childhood cancer survivors
ventricular torsion
Issue Date2011
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHO
Citation
Echocardiography, 2011, v. 28 n. 7, p. 738-745 How to Cite?
AbstractBackground: Anthracycline has been shown to degrade titin that plays a role in myocardial twisting and untwisting. This study aimed to test the hypothesis that left ventricular (LV) twisting and untwisting motion may be altered in children after anthracycline therapy. Methods: Thirty-six childhood leukemia survivors aged 15.6 ± 5.5 years and 20 healthy controls aged 16.8 ± 7.7 years (P = 0.54) were studied. LV twisting and untwisting motion was determined using speckle tracking imaging, whereas LV ejection fraction and systolic and diastolic mitral annular velocities were determined respectively by three-dimensional and tissue-Doppler echocardiography. Results: Compared with controls, patients had significantly lower LV ejection fraction (P = 0.01) but similar systolic and diastolic mitral annular velocities (all P > 0.05). Their peak LV torsion (P = 0.003), systolic twisting velocity (P < 0.001), and diastolic untwisting velocity (P = 0.04) were significantly lower than controls, which could be attributable to their reduced apical rotation (P = 0.03) and apical untwisting rate (P = 0.002). For the whole cohort, LV systolic torsion and twisting velocity correlated significantly with apical untwisting rate (P < 0.001) and LV diastolic untwisting velocity (P < 0.001). In patients, none of the twisting or untwisting parameters were found to correlate with cumulative anthracycline dose (all P > 0.05). Twenty-eight (78%) patients had LV ejection fractions ≥50%. Although their systolic and diastolic mitral annular velocities were similar to those of controls, their peak LV torsion (P = 0.005), apical untwisting rate (P = 0.01), and LV systolic twisting velocity (P = 0.001) remained significantly lower. Conclusion: Impairment of LV twisting and untwisting motion is evident in children after anthracycline therapy, even in those with "normal" LV ejection fractions. © 2011, Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/135338
ISSN
2014 Impact Factor: 1.254
2014 SCImago Journal Rankings: 0.602
ISI Accession Number ID
Funding AgencyGrant Number
Children's Cancer Foundation
CRCG, University of Hong Kong
Funding Information:

Children's Cancer Foundation and CRCG funding, The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorLi, SNen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2011-07-27T01:33:44Z-
dc.date.available2011-07-27T01:33:44Z-
dc.date.issued2011en_HK
dc.identifier.citationEchocardiography, 2011, v. 28 n. 7, p. 738-745en_HK
dc.identifier.issn0742-2822en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135338-
dc.description.abstractBackground: Anthracycline has been shown to degrade titin that plays a role in myocardial twisting and untwisting. This study aimed to test the hypothesis that left ventricular (LV) twisting and untwisting motion may be altered in children after anthracycline therapy. Methods: Thirty-six childhood leukemia survivors aged 15.6 ± 5.5 years and 20 healthy controls aged 16.8 ± 7.7 years (P = 0.54) were studied. LV twisting and untwisting motion was determined using speckle tracking imaging, whereas LV ejection fraction and systolic and diastolic mitral annular velocities were determined respectively by three-dimensional and tissue-Doppler echocardiography. Results: Compared with controls, patients had significantly lower LV ejection fraction (P = 0.01) but similar systolic and diastolic mitral annular velocities (all P > 0.05). Their peak LV torsion (P = 0.003), systolic twisting velocity (P < 0.001), and diastolic untwisting velocity (P = 0.04) were significantly lower than controls, which could be attributable to their reduced apical rotation (P = 0.03) and apical untwisting rate (P = 0.002). For the whole cohort, LV systolic torsion and twisting velocity correlated significantly with apical untwisting rate (P < 0.001) and LV diastolic untwisting velocity (P < 0.001). In patients, none of the twisting or untwisting parameters were found to correlate with cumulative anthracycline dose (all P > 0.05). Twenty-eight (78%) patients had LV ejection fractions ≥50%. Although their systolic and diastolic mitral annular velocities were similar to those of controls, their peak LV torsion (P = 0.005), apical untwisting rate (P = 0.01), and LV systolic twisting velocity (P = 0.001) remained significantly lower. Conclusion: Impairment of LV twisting and untwisting motion is evident in children after anthracycline therapy, even in those with "normal" LV ejection fractions. © 2011, Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHOen_HK
dc.relation.ispartofEchocardiographyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectanthracycline cardiotoxicityen_HK
dc.subjectchildhood cancer survivorsen_HK
dc.subjectventricular torsionen_HK
dc.subject.meshAnthracyclines - adverse effects - therapeutic use-
dc.subject.meshEchocardiography, Doppler - methods-
dc.subject.meshEchocardiography, Three-Dimensional - methods-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy-
dc.subject.meshVentricular Dysfunction, Left - chemically induced - physiopathology - ultrasonography-
dc.titleLeft ventricular twisting and untwisting motion in childhood cancer survivorsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8175.2011.01429.xen_HK
dc.identifier.pmid21615484en_HK
dc.identifier.scopuseid_2-s2.0-80955178801en_HK
dc.identifier.hkuros187930en_US
dc.identifier.hkuros194352-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80955178801&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue7en_HK
dc.identifier.spage738en_HK
dc.identifier.epage745en_HK
dc.identifier.isiWOS:000293906200015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridLi, SN=47161384100en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.citeulike9741570-

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