Article: Left ventricular twisting and untwisting motion in childhood cancer survivors
| Title | Left ventricular twisting and untwisting motion in childhood cancer survivors | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Cheung, YF1 Li, SN1 Chan, GCF1 Wong, SJ1 Ha, SY1 | ||||||
| Keywords | anthracycline cardiotoxicity childhood cancer survivors ventricular torsion | ||||||
| Issue Date | 2011 | ||||||
| Publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHO | ||||||
| Citation | Echocardiography, 2011, v. 28 n. 7, p. 738-745 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1540-8175.2011.01429.x | ||||||
| Abstract | Background: Anthracycline has been shown to degrade titin that plays a role in myocardial twisting and untwisting. This study aimed to test the hypothesis that left ventricular (LV) twisting and untwisting motion may be altered in children after anthracycline therapy. Methods: Thirty-six childhood leukemia survivors aged 15.6 ± 5.5 years and 20 healthy controls aged 16.8 ± 7.7 years (P = 0.54) were studied. LV twisting and untwisting motion was determined using speckle tracking imaging, whereas LV ejection fraction and systolic and diastolic mitral annular velocities were determined respectively by three-dimensional and tissue-Doppler echocardiography. Results: Compared with controls, patients had significantly lower LV ejection fraction (P = 0.01) but similar systolic and diastolic mitral annular velocities (all P > 0.05). Their peak LV torsion (P = 0.003), systolic twisting velocity (P < 0.001), and diastolic untwisting velocity (P = 0.04) were significantly lower than controls, which could be attributable to their reduced apical rotation (P = 0.03) and apical untwisting rate (P = 0.002). For the whole cohort, LV systolic torsion and twisting velocity correlated significantly with apical untwisting rate (P < 0.001) and LV diastolic untwisting velocity (P < 0.001). In patients, none of the twisting or untwisting parameters were found to correlate with cumulative anthracycline dose (all P > 0.05). Twenty-eight (78%) patients had LV ejection fractions ≥50%. Although their systolic and diastolic mitral annular velocities were similar to those of controls, their peak LV torsion (P = 0.005), apical untwisting rate (P = 0.01), and LV systolic twisting velocity (P = 0.001) remained significantly lower. Conclusion: Impairment of LV twisting and untwisting motion is evident in children after anthracycline therapy, even in those with "normal" LV ejection fractions. © 2011, Wiley Periodicals, Inc. | ||||||
| ISSN | 0742-2822 2011 Impact Factor: 1.239 2011 SCImago Journal Rankings: 0.098 | ||||||
| DOI | http://dx.doi.org/10.1111/j.1540-8175.2011.01429.x | ||||||
| ISI Accession Number ID | WOS:000293906200015
Funding Information: Children's Cancer Foundation and CRCG funding, The University of Hong Kong. | ||||||
| References | References in Scopus |
| dc.contributor.author | Cheung, YF | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Li, SN | ||||||
| dc.contributor.author | Chan, GCF | ||||||
| dc.contributor.author | Wong, SJ | ||||||
| dc.contributor.author | Ha, SY | ||||||
| dc.date.accessioned | 2011-07-27T01:33:44Z | ||||||
| dc.date.available | 2011-07-27T01:33:44Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Background: Anthracycline has been shown to degrade titin that plays a role in myocardial twisting and untwisting. This study aimed to test the hypothesis that left ventricular (LV) twisting and untwisting motion may be altered in children after anthracycline therapy. Methods: Thirty-six childhood leukemia survivors aged 15.6 ± 5.5 years and 20 healthy controls aged 16.8 ± 7.7 years (P = 0.54) were studied. LV twisting and untwisting motion was determined using speckle tracking imaging, whereas LV ejection fraction and systolic and diastolic mitral annular velocities were determined respectively by three-dimensional and tissue-Doppler echocardiography. Results: Compared with controls, patients had significantly lower LV ejection fraction (P = 0.01) but similar systolic and diastolic mitral annular velocities (all P > 0.05). Their peak LV torsion (P = 0.003), systolic twisting velocity (P < 0.001), and diastolic untwisting velocity (P = 0.04) were significantly lower than controls, which could be attributable to their reduced apical rotation (P = 0.03) and apical untwisting rate (P = 0.002). For the whole cohort, LV systolic torsion and twisting velocity correlated significantly with apical untwisting rate (P < 0.001) and LV diastolic untwisting velocity (P < 0.001). In patients, none of the twisting or untwisting parameters were found to correlate with cumulative anthracycline dose (all P > 0.05). Twenty-eight (78%) patients had LV ejection fractions ≥50%. Although their systolic and diastolic mitral annular velocities were similar to those of controls, their peak LV torsion (P = 0.005), apical untwisting rate (P = 0.01), and LV systolic twisting velocity (P = 0.001) remained significantly lower. Conclusion: Impairment of LV twisting and untwisting motion is evident in children after anthracycline therapy, even in those with "normal" LV ejection fractions. © 2011, Wiley Periodicals, Inc. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Echocardiography, 2011, v. 28 n. 7, p. 738-745 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1540-8175.2011.01429.x | ||||||
| dc.identifier.citeulike | 9741570 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1540-8175.2011.01429.x | ||||||
| dc.identifier.epage | 745 | ||||||
| dc.identifier.hkuros | 187930 | ||||||
| dc.identifier.hkuros | 194352 | ||||||
| dc.identifier.isi | WOS:000293906200015
Funding Information: Children's Cancer Foundation and CRCG funding, The University of Hong Kong. | ||||||
| dc.identifier.issn | 0742-2822 2011 Impact Factor: 1.239 2011 SCImago Journal Rankings: 0.098 | ||||||
| dc.identifier.issue | 7 | ||||||
| dc.identifier.pmid | 21615484 | ||||||
| dc.identifier.scopus | eid_2-s2.0-80955178801 | ||||||
| dc.identifier.spage | 738 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/135338 | ||||||
| dc.identifier.volume | 28 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECHO | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Echocardiography | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | The definitive version is available at www.blackwell-synergy.com | ||||||
| dc.subject.mesh | Anthracyclines - adverse effects - therapeutic use | ||||||
| dc.subject.mesh | Echocardiography, Doppler - methods | ||||||
| dc.subject.mesh | Echocardiography, Three-Dimensional - methods | ||||||
| dc.subject.mesh | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | ||||||
| dc.subject.mesh | Ventricular Dysfunction, Left - chemically induced - physiopathology - ultrasonography | ||||||
| dc.subject | anthracycline cardiotoxicity | ||||||
| dc.subject | childhood cancer survivors | ||||||
| dc.subject | ventricular torsion | ||||||
| dc.title | Left ventricular twisting and untwisting motion in childhood cancer survivors | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong