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Article: Torsional mechanics of the left ventricle in patients after surgical repair of tetralogy of Fallot

TitleTorsional mechanics of the left ventricle in patients after surgical repair of tetralogy of Fallot
Authors
KeywordsSpeckle tracking echocardiography
Tetralogy of fallot
Ventricular torsion
Issue Date2011
PublisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/
Citation
Circulation Journal, 2011, v. 75 n. 7, p. 1735-1741 How to Cite?
AbstractBackground: This study aimed to test the hypothesis that alteration of left ventricular (LV) torsional mechanics occurs in patients after repair of tetralogy of Fallot (TOF) and is associated with right ventricular (RV) volume overload and changes in LV configuration. Methods and Results: Fifty-five TOF patients aged 19.0±8.1 years and 27 age-matched healthy controls were studied. The LV and RV volumes were measured using 3-dimensional echocardiography while LV geometry was quantified by the diastolic eccentricity index (EI). The LV peak systolic torsion and systolic twisting and diastolic untwisting velocities were determined by speckle tracking. Compared with controls, patients had significantly greater RV end-systolic (P<0.001) and diastolic (P<0.001) volumes and LV diastolic EI (P<0.001). In contrast, LV peak apical rotation (P<0.001), systolic torsion (P=0.004), systolic twisting velocity (P=0.001), and diastolic untwisting velocity (P=0.001) were lower in patients than in controls. For the whole cohort, RV EDV and LV diastolic EI correlated negatively with peak systolic torsion, systolic twisting velocity, and diastolic untwisting velocity (all P≤0.001). Systolic torsion correlated strongly with diastolic untwisting velocity (r=0.72, P<0.001), while systolic twisting velocity correlated with LV ejection fraction (r=0.3, P=0.005). Conclusions: LV torsional mechanics is impaired and is negatively related to RV volume overload and LV eccentricity in patients after TOF repair.
Persistent Identifierhttp://hdl.handle.net/10722/135334
ISSN
2015 Impact Factor: 4.124
2015 SCImago Journal Rankings: 1.728
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorLiang, XCen_HK
dc.contributor.authorCheung, EWYen_HK
dc.date.accessioned2011-07-27T01:33:41Z-
dc.date.available2011-07-27T01:33:41Z-
dc.date.issued2011en_HK
dc.identifier.citationCirculation Journal, 2011, v. 75 n. 7, p. 1735-1741en_HK
dc.identifier.issn1346-9843en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135334-
dc.description.abstractBackground: This study aimed to test the hypothesis that alteration of left ventricular (LV) torsional mechanics occurs in patients after repair of tetralogy of Fallot (TOF) and is associated with right ventricular (RV) volume overload and changes in LV configuration. Methods and Results: Fifty-five TOF patients aged 19.0±8.1 years and 27 age-matched healthy controls were studied. The LV and RV volumes were measured using 3-dimensional echocardiography while LV geometry was quantified by the diastolic eccentricity index (EI). The LV peak systolic torsion and systolic twisting and diastolic untwisting velocities were determined by speckle tracking. Compared with controls, patients had significantly greater RV end-systolic (P<0.001) and diastolic (P<0.001) volumes and LV diastolic EI (P<0.001). In contrast, LV peak apical rotation (P<0.001), systolic torsion (P=0.004), systolic twisting velocity (P=0.001), and diastolic untwisting velocity (P=0.001) were lower in patients than in controls. For the whole cohort, RV EDV and LV diastolic EI correlated negatively with peak systolic torsion, systolic twisting velocity, and diastolic untwisting velocity (all P≤0.001). Systolic torsion correlated strongly with diastolic untwisting velocity (r=0.72, P<0.001), while systolic twisting velocity correlated with LV ejection fraction (r=0.3, P=0.005). Conclusions: LV torsional mechanics is impaired and is negatively related to RV volume overload and LV eccentricity in patients after TOF repair.en_HK
dc.languageengen_US
dc.publisherJapanese Circulation Society. The Journal's web site is located at http://www.j-circ.or.jp/english/publications/en_HK
dc.relation.ispartofCirculation Journalen_HK
dc.subjectSpeckle tracking echocardiographyen_HK
dc.subjectTetralogy of falloten_HK
dc.subjectVentricular torsionen_HK
dc.titleTorsional mechanics of the left ventricle in patients after surgical repair of tetralogy of Falloten_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1253/circj.CJ-10-1253en_HK
dc.identifier.pmid21566339-
dc.identifier.scopuseid_2-s2.0-79959693424en_HK
dc.identifier.hkuros187093en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959693424&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1735en_HK
dc.identifier.epage1741en_HK
dc.identifier.isiWOS:000292342600032-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridLiang, XC=12803290200en_HK
dc.identifier.scopusauthoridCheung, EWY=9432819700en_HK

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