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Article: High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects

TitleHigh plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
Authors
Issue Date2011
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2011, v. 34 n. 9, p. 2113-2115 How to Cite?
AbstractOBJECTIVE - To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS - Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with diabetes development over 5.4 years was analyzed using multiple logistic regression. RESULTS - At baseline, plasma levels of FGF21 increased progressively with worsening dysglycemia from normal glucose tolerance, through prediabetes, to diabetes (global trend, P < 0.001). Of 1,292 subjects without diabetes at baseline, a high baseline FGF21 level was a strong independent predictor for diabetes development (odds ratio 1.792; P < 0.01), together with waist circumference and fasting plasma glucose levels. CONCLUSIONS - Plasma FGF21 levels were significantly increased in subjects with prediabetes and diabetes and predicted the development of diabetes in humans. © 2011 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/135251
ISSN
2014 Impact Factor: 8.420
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong KongHKU3/CRF/09
Funding Information:

This study was supported by the Research Grants Council Collaborative Research Fund (HKU3/CRF/09) (to K.S.L.L.), the matching fund for the National "973" Project, and the seeding fund for basic research from the University of Hong Kong (to A.X.).

References

 

DC FieldValueLanguage
dc.contributor.authorChen, Cen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-07-27T01:30:34Z-
dc.date.available2011-07-27T01:30:34Z-
dc.date.issued2011en_HK
dc.identifier.citationDiabetes Care, 2011, v. 34 n. 9, p. 2113-2115en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135251-
dc.description.abstractOBJECTIVE - To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS - Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with diabetes development over 5.4 years was analyzed using multiple logistic regression. RESULTS - At baseline, plasma levels of FGF21 increased progressively with worsening dysglycemia from normal glucose tolerance, through prediabetes, to diabetes (global trend, P < 0.001). Of 1,292 subjects without diabetes at baseline, a high baseline FGF21 level was a strong independent predictor for diabetes development (odds ratio 1.792; P < 0.01), together with waist circumference and fasting plasma glucose levels. CONCLUSIONS - Plasma FGF21 levels were significantly increased in subjects with prediabetes and diabetes and predicted the development of diabetes in humans. © 2011 by the American Diabetes Association.en_HK
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.rightsThis is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]-
dc.titleHigh plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjectsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=34&issue=9&spage=2113&epage=2115&date=2011&atitle=High+plasma+level+of+fibroblast+growth+factor+21+is+an+independent+predictor+of+type+2+diabetes:+a+5.4-year+population-based+prospective+study+in+Chinese+subjects-
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.2337/dc11-0294en_HK
dc.identifier.pmid21750278-
dc.identifier.pmcidPMC3161267-
dc.identifier.scopuseid_2-s2.0-84855473367en_HK
dc.identifier.hkuros188629en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855473367&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2113en_HK
dc.identifier.epage2115en_HK
dc.identifier.isiWOS:000295195100039-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, C=37025734000en_HK
dc.identifier.scopusauthoridCheung, BMY=55061052400en_HK
dc.identifier.scopusauthoridTso, AWK=55212830600en_HK
dc.identifier.scopusauthoridWang, Y=40762526800en_HK
dc.identifier.scopusauthoridLaw, LSC=55212861700en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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