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Article: High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
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TitleHigh plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
 
AuthorsChen, C1
Cheung, BMY1
Tso, AWK1
Wang, Y1
Law, LSC1
Ong, KL2
Wat, NMS1
Xu, A1
Lam, KSL1
 
Issue Date2011
 
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
 
CitationDiabetes Care, 2011, v. 34 n. 9, p. 2113-2115 [How to Cite?]
DOI: http://dx.doi.org/10.2337/dc11-0294
 
AbstractOBJECTIVE - To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS - Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with diabetes development over 5.4 years was analyzed using multiple logistic regression. RESULTS - At baseline, plasma levels of FGF21 increased progressively with worsening dysglycemia from normal glucose tolerance, through prediabetes, to diabetes (global trend, P < 0.001). Of 1,292 subjects without diabetes at baseline, a high baseline FGF21 level was a strong independent predictor for diabetes development (odds ratio 1.792; P < 0.01), together with waist circumference and fasting plasma glucose levels. CONCLUSIONS - Plasma FGF21 levels were significantly increased in subjects with prediabetes and diabetes and predicted the development of diabetes in humans. © 2011 by the American Diabetes Association.
 
ISSN0149-5992
2012 Impact Factor: 7.735
2012 SCImago Journal Rankings: 3.758
 
DOIhttp://dx.doi.org/10.2337/dc11-0294
 
PubMed Central IDPMC3161267
 
ISI Accession Number IDWOS:000295195100039
Funding AgencyGrant Number
University of Hong KongHKU3/CRF/09
Funding Information:

This study was supported by the Research Grants Council Collaborative Research Fund (HKU3/CRF/09) (to K.S.L.L.), the matching fund for the National "973" Project, and the seeding fund for basic research from the University of Hong Kong (to A.X.).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, C
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorWang, Y
 
dc.contributor.authorLaw, LSC
 
dc.contributor.authorOng, KL
 
dc.contributor.authorWat, NMS
 
dc.contributor.authorXu, A
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2011-07-27T01:30:34Z
 
dc.date.available2011-07-27T01:30:34Z
 
dc.date.issued2011
 
dc.description.abstractOBJECTIVE - To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS - Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with diabetes development over 5.4 years was analyzed using multiple logistic regression. RESULTS - At baseline, plasma levels of FGF21 increased progressively with worsening dysglycemia from normal glucose tolerance, through prediabetes, to diabetes (global trend, P < 0.001). Of 1,292 subjects without diabetes at baseline, a high baseline FGF21 level was a strong independent predictor for diabetes development (odds ratio 1.792; P < 0.01), together with waist circumference and fasting plasma glucose levels. CONCLUSIONS - Plasma FGF21 levels were significantly increased in subjects with prediabetes and diabetes and predicted the development of diabetes in humans. © 2011 by the American Diabetes Association.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationDiabetes Care, 2011, v. 34 n. 9, p. 2113-2115 [How to Cite?]
DOI: http://dx.doi.org/10.2337/dc11-0294
 
dc.identifier.doihttp://dx.doi.org/10.2337/dc11-0294
 
dc.identifier.epage2115
 
dc.identifier.hkuros188629
 
dc.identifier.isiWOS:000295195100039
Funding AgencyGrant Number
University of Hong KongHKU3/CRF/09
Funding Information:

This study was supported by the Research Grants Council Collaborative Research Fund (HKU3/CRF/09) (to K.S.L.L.), the matching fund for the National "973" Project, and the seeding fund for basic research from the University of Hong Kong (to A.X.).

 
dc.identifier.issn0149-5992
2012 Impact Factor: 7.735
2012 SCImago Journal Rankings: 3.758
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3161267
 
dc.identifier.pmid21750278
 
dc.identifier.scopuseid_2-s2.0-84855473367
 
dc.identifier.spage2113
 
dc.identifier.urihttp://hdl.handle.net/10722/135251
 
dc.identifier.volume34
 
dc.languageeng
 
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDiabetes Care
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThis is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]
 
dc.titleHigh plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
 
dc.typeArticle
 
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<contributor.author>Law, LSC</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Heart Research Institute Australia