Guillain-Barre syndrome associated with acute hepatitis E infection

Abstract

Guillain–Barré syndrome (GBS) is a neurological emergency that warrants prompt diagnosis and treatment. Occasionally, the clinical, laboratory and electrophysiological features are neither typical nor diagnostic. It requires a high index of suspicion and clinical judgement for early diagnosis and commencement of treatment in those scenarios. Some pathogens are potential triggers of this serious neurological disease, including: Campylobacter jejuni, Mycoplasma pneumoniae and cytomegalovirus. Although uncommon, hepatotrophic viruses (hepatitis A, B and C) are increasingly recognized to be triggering microbes. Here, we report a patient with unusual GBS triggered by an atypical microbe, hepatitis E virus, in a Chinese patient, via a common route of transmission in this locality.